期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 47, 页码 23643-23652出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1912432116
关键词
microbiota; skin; keratinocyte; antigen presentation; Th1
资金
- NIAID Division of Intramural Research [ZIA-AI001115, ZIA-AI001132]
- National Institute of Diabetes and Digestive and Kidney Diseases
- NIH
- European Molecular Biology Organization [ALTF 1535-2014]
- Association pour la Recherche sur le Cancer
- National Institute of General Medical Sciences
- College des Enseignants de Dermatologie Francais
- Societe Francaise de Dermatologie
- Philippe Foundation
- Fondation pour la Recherche Medicale
- Cancer Research Institute Irvington
The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium. These organized lymphocyte clusters are surrounded by keratinocytes expressing a discrete program associated with antigen presentation and antimicrobial defense. Notably, IL-22-mediated keratinocyte-intrinsic MHC class II expression was required for the selective accumulation of commensal-induced IFN-gamma, but not IL-17A-producing CD4(+) T cells within the skin. Taking these data together, this work uncovers an unexpected role for MHC class II expression by keratinocytes in the control of homeostatic type 1 responses to the microbiota. Our findings have important implications for the understanding of the tissue-specific rules governing the dialogue between a host and its microbiota.
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