Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs

(2018) Monique G. P. van der Wijst et al.   NATURE GENETICS

Validated Living Worldwide Supercentenarians, Living and Recently Deceased: February 2018

(2018) Robert D. Young   REJUVENATION RESEARCH

Single-cell mRNA quantification and differential analysis with Census

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VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

(2017) Mikhail Shugay et al.   NUCLEIC ACIDS RESEARCH

Single-cell transcriptomics to explore the immune system in health and disease

(2017) Michael J. T. Stubbington et al.   SCIENCE

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

(2017) Yuan Tian et al.   Nature Communications

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

(2017) Woosung Chung et al.   Nature Communications

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

CRTAM determines the CD4+cytotoxic T lymphocyte lineage

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Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

(2015) Yasumichi Arai et al.   EBioMedicine

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

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How Do CD4+ T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?

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The who's who of T-cell differentiation: Human memory T-cell subsets

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Physical Independence and Mortality at the Extreme Limit of Life Span: Supercentenarians Study in Japan

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Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

STAR: ultrafast universal RNA-seq aligner

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Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span

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Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Cancer prevalence and mortality in centenarians: A systematic review

(2011) Nicholas Pavlidis et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Life at the Extreme Limit: Phenotypic Characteristics of Supercentenarians in Okinawa

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

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HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Reference values for B cell subpopulations from infancy to adulthood

(2010) H. Morbach et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

B cell repertoire and ageing

(2010) Deborah K Dunn-Walters et al.   CURRENT OPINION IN IMMUNOLOGY

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ageing B cell population: Composition and function

(2009) Alexander Ademokun et al.   BIOGERONTOLOGY