Review
Immunology
August Mikucki, Nicolie R. McCluskey, Charlene M. Kahler
Summary: This review focuses on the competition between Neisseria meningitidis and other Neisseria species in the nasopharynx, as well as the impact of genetic diversity on the pathogenic potential of meningococcus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Marcia S. Pereira, Martin A. Kriegel
Summary: Autoimmune diseases are complex, multifactorial disorders characterized by polygenic traits and various environmental factors. The human microbiome plays an increasing role in the multistep pathogenesis of autoimmune diseases. This article summarizes the latest research on the cellular and molecular interactions between the microbiota and the host. It reviews how pathobionts evolve within the gut and trigger autoimmune pathways through various mechanisms, leading to the development of unconventional therapeutic approaches for autoimmune diseases.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Cell Biology
Justin A. Hayes, Anna W. Lunger, Aayushi S. Sharma, Matthew T. Fernez, Rebecca L. Carrier, Abigail N. Koppes, Ryan Koppes, Benjamin M. Woolston
Summary: This study successfully engineered a gut microphysiological model to titrate H2S gas and study the interactions between microbes and host cells. By visualizing in real time and analyzing gene expression, it was found that changes in H2S concentration led to alterations in host gene expression and metabolism.
Review
Oncology
Ramsha Mahmood, Athalia Voisin, Hana Olof, Reihane Khorasaniha, Samuel A. Lawal, Heather K. Armstrong
Summary: This review discusses the role of microbiomes in mediating interactions between dietary factors, inflammation, and different cancers. Dysbiosis, or disruptions in the microbiome, have been associated with various diseases including cancer. Understanding how different microbiomes interact with dietary factors can help improve interventions for cancer patients in the future.
Review
Neurosciences
Dag Nyholm, Per M. Hellstrom
Summary: Certain studies have shown a 1.6-fold higher prevalence of Helicobacter pylori in Parkinson's disease patients compared to control populations. The eradication of Helicobacter pylori can lead to an improved response to levodopa therapy in Parkinson's disease, likely due to increased bioavailability of the drug. Patients with both Helicobacter pylori infection and Parkinson's disease on levodopa therapy tend to have worse motor control than those without the infection.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Maria A. Nunez-Sanchez, Silvia Melgar, Keith O'Donoghue, Maria A. Martinez-Sanchez, Virgina E. Fernandez-Ruiz, Mercedes Ferrer-Gomez, Antonio J. Ruiz-Alcaraz, Bruno Ramos-Molina
Summary: Crohn's disease (CD) is a complex and disabling disorder with unknown etiology. The gut microbiota plays a crucial role in CD development, and dietary strategies may impact the composition and functionality of the gut microbiota. This review provides an overview of host-microbe interactions in CD pathogenesis and severity, and discusses the latest information on modulating gut microbiota through nutritional strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Amanda Sudworth, Filip M. Segers, Bahtiyar Yilmaz, Naomi C. Guslund, Andrew J. Macpherson, Erik Dissen, Shuo-Wang Qiao, Marit Inngjerdingen
Summary: This study provides a comprehensive characterization of innate lymphoid cells (ILCs) in rats, revealing the distribution of different ILC types in various tissues and confirming the similarity between rat ILC1s and NK cells. Furthermore, the study highlights the differential distribution of NK cells and ILCs in the intestines and their association with specific bacterial taxa.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Oana Sasaran, Lorena Elena Melit, Ecaterina Daniela Dobru
Summary: Helicobacter pylori is the most researched etiological factor for gastric inflammation and malignancies, with Toll-like receptors playing a key role in recognizing the bacterium. MicroRNAs modulate TLR signaling and are regulated by NF-κB-dependent pathways. Certain MiRNAs can potentially serve as non-invasive biomarkers for discriminating H. pylori infection and associated complications, connecting gastric inflammation to pre-neoplastic and malignant lesions. Further research is needed to clarify the exact involvement of these entities in the progression of H. pylori-associated gastric conditions, especially in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Heloise Tudela, Sandrine P. Claus, Maya Saleh
Summary: The gut microbiota, a diverse community of microorganisms in the gastrointestinal tract, has a significant impact on health and disease. Keystone species, essential microbes for microbiota balance, play crucial roles in maintaining essential functions and their identification is crucial for the development of microbiome-based therapeutics. Understanding the functions of keystone species is a major step towards comprehending microbiome dynamics in disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Christopher J. Stewart
Summary: Breast milk is a complex biofluid that has evolved over millions of years to provide optimal nutrition and bioactive compounds to infants. Human milk oligosaccharides (HMOs) are the fourth most abundant component in breast milk, more abundant than proteins and other nutrients, but they do not directly contribute to infant nutrition. Recent studies have shown that HMOs act as prebiotics, which suggests that they play a crucial role in infant development, indicating the importance of understanding the interaction between diet, microbes, and the host for improving human health.
Article
Pharmacology & Pharmacy
Hui Wang, Nivedita Banerjee, Yuejin Liang, Gangduo Wang, Kristi L. Hoffman, M. Firoze Khan
Summary: Trichloroethene (TCE) exposure is associated with the development of autoimmune diseases (ADs), with altered gut microbiome composition being a key factor. Studies on female MRL+/+ mice exposed to TCE revealed distinct changes in bacterial community and increased colonic oxidative stress and inflammatory markers. Fecal microbiota transplantation (FMT) experiments further supported the causal role of microbiome in TCE-mediated autoimmunity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Immunology
Sophie Curio, Gabrielle T. Belz
Summary: This article discusses the role of ILCs in cancer, focusing on their relationship with liver and liver-related diseases. NK cells and ILC1s play important roles in hepatic diseases, but are underexplored areas of research.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Microbiology
Ju-Hyung Lee, Joo-Hong Park
Summary: The gut microbiome is believed to play a crucial role in metabolic diseases and altering it could lead to metabolic disorders. Manipulating the gut microbiome may represent a new treatment approach for obesity, type 2 diabetes, and nonalcoholic fatty liver disease.
JOURNAL OF MICROBIOLOGY
(2022)
Review
Immunology
Shivani Singh, Jake G. Natalini, Leopoldo N. Segal
Summary: In recent years, our understanding of the microbial world within us has been revolutionized by culture-independent techniques. Advances in bioinformatics have enabled comprehensive analysis of the role of the human microbiome in different conditions. Despite challenges in lower airway research, new approaches will facilitate further progress.
MUCOSAL IMMUNOLOGY
(2022)
Article
Microbiology
Francesco Ricci, Kshitij Tandon, Jay R. Black, Kim-Anh Le Cao, Linda L. Blackall, Heroen Verbruggen
Summary: The success of tropical scleractinian corals depends on their ability to establish symbioses with microbial partners. This study investigated the influence of host phylogeny, skeletal architecture, and reproductive mode on the coral microbiome composition. The results showed that these factors contributed to shaping the presence and relative abundance of bacterial symbionts in the coral holobiont. Additionally, the study revealed differences in the tissue and skeleton bacterial communities, suggesting that the skeleton can act as a microbial reservoir. The findings provide insights into coral-bacterial symbioses and have implications for reef management measures.
Article
Immunology
Yong Ge, Minghao Gong, Natacha Colliou, Mojgan Zadeh, Jing Li, Dean P. Jones, Shuzhao Li, Mansour Mohamadzadeh
MUCOSAL IMMUNOLOGY
(2019)
Article
Cell Biology
Zheng Fu, Jian Ye, Joseph W. Dean, John W. Bostick, Samuel E. Weinberg, Lifeng Xiong, Kristen N. Oliff, Zongming E. Chen, Dorina Avram, Navdeep S. Chandel, Liang Zhou
Article
Medicine, General & Internal
Catherine D. Morffy Smith, Minghao Gong, Alicer K. Andrew, Brittany N. Russ, Yong Ge, Mojgan Zadeh, Caitlin A. Cooper, Mansour Mohamadzadeh, Julie M. Moore
Article
Immunology
Yong Ge, Minghao Gong, Mojgan Zadeh, Jing Li, Jeffrey R. Abbott, Wei Li, Laurence Morel, Roberto Sonon, Nitin T. Supekar, Parastoo Azadi, Yating Wang, Dean P. Jones, Shuzhao Li, Mansour Mohamadzadeh
MUCOSAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Jing Li, Yong Ge, Mojgan Zadeh, Roy Curtiss, Mansour Mohamadzadeh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cell Biology
Seung-Chul Choi, Josephine Brown, Minghao Gong, Yong Ge, Mojgan Zadeh, Wei Li, Byron P. Croker, George Michailidis, Timothy J. Garrett, Mansour Mohamadzadeh, Laurence Morel
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Lifeng Xiong, Joseph W. Dean, Zheng Fu, Kristen N. Oliff, John W. Bostick, Jian Ye, Zongming E. Chen, Marcus Muhlbauer, Liang Zhou
SCIENCE IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Anoop Kumar, Shubha Priyamvada, Yong Ge, Dulari Jayawardena, Megha Singhal, Arivarasu N. Anbazhagan, Ishita Chatterjee, Aneal Dayal, Mitul Patel, Kimia Zadeh, Seema Saksena, Waddah A. Alrefai, Ravinder K. Gill, Mojgan Zadeh, Ni Zhao, Mansour Mohamadzadeh, Pradeep K. Dudeja
Summary: The study demonstrated that DRA deficiency results in increased colonic paracellular permeability and decreased levels of tight junction/adherens junction proteins. Dysregulation of DRA may have potential implications for IBD pathogenesis by compromising intestinal epithelial barrier function.
Editorial Material
Neurosciences
John W. Bostick, Sarkis K. Mazmanian
NATURE NEUROSCIENCE
(2022)
Article
Immunology
Yong Ge, Mojgan Zadeh, Mansour Mohamadzadeh
Summary: Deprivation of vitamin B12 affects the functions of ileal epithelial cells and gut microbiome, leading to the progression of pathogen infections. Vitamin B12 coordinates ileal epithelial mitochondrial metabolism and regulates epithelial oxygenation, controlling aerobic pathogen infections.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Yong Ge, Mojgan Zadeh, Mansour Mohamadzadeh
Summary: This study demonstrates that Vitamin B12 plays an essential role in regulating cellular homeostasis and metabolism in human intestinal epithelial cells, influencing fatty acid metabolism, cell proliferation, and inflammatory responses.
Article
Clinical Neurology
Joseph C. C. Boktor, Gil Sharon, Leo A. A. Verhagen Metman, Deborah A. A. Hall, Phillip A. A. Engen, Zoe Zreloff, Daniel J. J. Hakim, John W. W. Bostick, James Ousey, Danielle Lange, Gregory Humphrey, Gail Ackermann, Martha Carlin, Rob Knight, Ali Keshavarzian, Sarkis K. Mazmanian
Summary: This study analyzes the gut microbiome of patients with Parkinson's disease (PD) and controls, and finds significant alterations in microbial composition, taxon abundance, metabolic pathways, and microbial gene products in PD patients. These changes may be related to disease progression.
MOVEMENT DISORDERS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yong Ge, Shatha Bamashmous, Deborah Mancinelli-Lyle, Mojgan Zadeh, Mansour Mohamadzadeh, Georgios A. Kotsakis
Summary: This study evaluated the effect of different oral irrigators on the sub-gingival microbiome composition. The results showed that using oral irrigators can reduce gingival inflammation, and oral irrigators outperformed flossing in reducing bleeding-on-probing. The study also found that there was an increase in commensal bacteria and a decrease in periodontal pathogens during the treatment period.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
