Article
Engineering, Environmental
Ling Cai, Xinyi Zhu, Hongjie Ruan, Jing Yang, Wei Wei, Yuan Wu, Liuzhu Zhou, Huijun Jiang, Minghui Ji, Jin Chen
Summary: Due to antibiotic misuse, the emergence of drug-resistant pathogenic microbes has raised concern for public health. This study successfully encapsulated curcumin-reduced and stabilized silver nanoparticles (C-Ag NPs) into electrospun nanofiber membranes composed of polyvinyl alcohol (PVA) cross-linked with citric acid (CA), which demonstrated desirable biocompatibility and broad-spectrum antimicrobial activities. The constructed nanofibrous scaffolds exhibited a homogeneously distributed and sustained release of C-Ag NPs, resulting in a significant killing effect against Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans, mediated by reactive oxygen species (ROS) generation. Transcriptomic analysis revealed that PVA/CA/C-Ag disrupted carbohydrate and energy metabolism and bacterial membranes, suggesting its potential in overcoming bacterial resistance and eradicating drug-resistant pathogenic microbes in various applications.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Lisa M. Stabryla, Kathryn A. Johnston, Nathan A. Diemler, Vaughn S. Cooper, Jill E. Millstone, Sarah-Jane Haig, Leanne M. Gilbertson
Summary: Bacterial motility can be a significant predictor of AgNP resistance, guiding the development of nanoenabled antimicrobials. The study of bacterial resistance to AgNPs is still in its early stages, with limited understanding of the underlying mechanisms. The resistance to subinhibitory concentrations of AgNPs in Escherichia coli K-12 MG1655 strain was found to be associated with a cusS mutation, potentially enhancing silver ion efflux and suggesting a role for flagellum-based motility in the resistance mechanism.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Li Wang, Govindasami Periyasami, Ali Aldalbahi, Vincenzo Fogliano
Summary: The study compared the effects of chitosan and PVA-based BSNPs films on the growth of Pseudomonas fluorescens, showing that PVA-based BSNPs film exhibited stronger antimicrobial effects. This is attributed to the higher amount of silver ions released from the PVA film into the hydrogel.
Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bojana Bozic Cvijan, Jelena Korac Jacic, Milica Bajcetic
Summary: Copper is an essential trace metal that can impact the activity of antibiotics by forming complexes and degrading antibiotic structure. In vitro studies have shown interactions between copper ions and various antibiotics in clinical use, and caution should be exercised when using prescribed antibiotics in patients with altered copper levels. Additionally, several copper-dependent compounds with antibacterial activity have been discovered. Further investigation is needed to explore the potential of copper-antibiotic interactions in changing the efficiency of antimicrobial therapy.
Article
Chemistry, Inorganic & Nuclear
Saheed Ademola Ibraheem, Ephraim Akuaden Audu, Adudu Judy Atabat, Mas 'ud Jaafar, Balarabe Fatima Tanimu, Jibrin Yusuf Yahaya, Jeffrey Tsware Barminas
Summary: This study reports a simple and rapid synthesis method of silver nanoparticles using pectin as a reducing and stabilizing agent. The synthesized nanoparticles were characterized using various techniques, and showed good dispersion and antibacterial activity against Escherichia coli. The study highlights the potential applications of these silver nanoparticles in various fields.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Plant Sciences
Jana Michailidu, Olga Matatkova, Irena Kolouchova, Jan Masak, Alena Cejkova
Summary: This study confirmed that ethanolic Vitis vinifera cane extract combined with silver nitrate can effectively produce silver nanoparticles with significant antimicrobial properties against Pseudomonas aeruginosa bacteria. Moreover, the use of wine agriculture waste is an ecological and economical method for the production of silver nanoparticles.
Article
Chemistry, Multidisciplinary
Arturo Barjola, Maria Angeles Tormo-Mas, Oscar Sahuquillo, Patricia Bernabe-Quispe, Jose Manuel Perez, Enrique Gimenez
Summary: A novel carboxylated graphene oxide-silver nanoparticle material was synthesized, which exhibited better antibacterial and antibiofilm-forming activities than traditional graphene oxide-silver nanoparticles. The carboxylated graphene oxide surface allowed for smaller-sized and better-distributed silver nanoparticles.
Article
Microbiology
Pijush C. Dey, Birson Ingti, Amitabha Bhattacharjee, Manabendra D. Choudhury, Ratan Das, Siddhartha S. Nath
Summary: This study synthesized CdS and Ag-doped CdS nanocrystals and tested their antimicrobial activity on Escherichia coli and Staphylococcus aureus. The results show that both nanocrystals are ineffective against E. coli but effective against S. aureus, with Ag-doped CdS showing more significant inhibition effects than CdS.
JOURNAL OF BASIC MICROBIOLOGY
(2021)
Article
Infectious Diseases
Ranj Nadhim Salaie, Pakhshan A. Hassan, Zhala Dara Meran, Shehab Ahmed Hamad
Summary: This research investigated the antibacterial activity of dissolved silver from silver-coated titanium implants against Streptococcus mutans. The results showed that the dissolved silver exhibited some degree of antibacterial activity by preventing the growth of Streptococcus mutans, but did not significantly affect the antibiofilm activity.
Article
Biochemistry & Molecular Biology
Tachita Vlad-Bubulac, Corneliu Hamciuc, Diana Serbezeanu, Ana-Maria Macsim, Gabriela Lisa, Ion Anghel, Dana-Maria Preda, Yuri Kalvachev, Cristina Mihaela Rimbu
Summary: The design and manufacture of innovative multifunctional materials with superior characteristics and standards are crucial for the future development of advanced technologies. Adjusting the properties of epoxy resins using organophosphorus compounds and silver-containing additives can improve their flame-resistant and antimicrobial properties.
Article
Infectious Diseases
Glaucia Rigotto Caruso, Ludmilla Tonani, Priscyla Daniely Marcato, Marcia Regina von Zeska Kress
Summary: This study evaluated the antifungal activity and toxicity of APDT using AgNPs-PS, showing synergistic effects and lack of toxicity to G. melonella. Therefore, APDT with AgNPs-PS is a promising therapeutic alternative for fungal infections.
Article
Engineering, Environmental
Ammar Tarar, Ching-An Peng
Summary: In this study, silver nanoparticles with enhanced antibacterial activity were synthesized using sinigrin as both reducing and capping agent. The sinigrin-capped silver nanoparticles exhibited increased zone of inhibition against E. coli and prolonged inhibitory effect on bacterial growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Diyana Kamarudin, N. Awanis Hashim, Boon Hoong Ong, Yuriko Kakihana, Mitsuru Higa, Hideto Matsuyama
Summary: Impregnation of noble metal silver nanoparticles (AgNPs) into polymeric membranes is an effective method for producing safe drinking water. The study showed that membranes with AgNPs-1 and AgNPs-2 exhibited improved mechanical properties and pure water flux when fabricated at higher temperatures. Despite different levels of silver release during fabrication, all membranes showed no leaching during dead-end filtration and demonstrated excellent antibacterial performance against E. coli.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Ramalingam Balachandar, Rajendran Navaneethan, Muniyandi Biruntha, Krishna Kumar Ashok Kumar, Muthusamy Govarthanan, Natchimuthu Karmegam
Summary: In this study, silver nanoparticles were synthesized using the ethyl acetate extract of Glochidion candolleanum leaves and showed strong antibacterial activity against Salmonella enterica and Pseudomonas aeruginosa. GC-MS analysis revealed the presence of various bioactive phytochemicals in the extract.
Article
Biochemistry & Molecular Biology
Masudulla Khan, Azhar U. Khan, Mohd Rafatullah, Mahboob Alam, Nina Bogdanchikova, Diana Garibo
Summary: The study presents the synthesis of silver nanoparticles using Purpureocillium lilacinum fungus cell filtrate and demonstrates their potential as effective fungicides and nematicides for improving agricultural production and food safety. The nanoparticles showed inhibitory activity against pathogenic fungi and nematodes.
Article
Chemistry, Physical
A. Uneputty, A. Davila-Lezama, D. Garibo, A. Oknianska, N. Bogdanchikova, J. F. Hernandez-Sanchez, A. Susarrey-Arce
Summary: This review presents various promising strategies to prevent bacterial contamination of surfaces, including anti-adhesive, contact active, biocide attached/biocide release, and topographical modification approaches. These methods can effectively reduce bacterial adhesion and contamination of surfaces.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Danna L. Arellano, Patricia Juarez, Andrea Verdugo-Meza, Paloma S. Almeida-Luna, Juan A. Corral-Avila, Florian Drescher, Felipe Olvera, Samanta Jimenez, Bennett D. Elzey, Theresa A. Guise, Pierrick G. J. Fournier
Summary: Immunotherapies using components of the immune system, such as T cells, have shown durable responses in fighting cancer cells. However, the effectiveness of immunotherapy in treating bone metastases remains uncertain. Research has found that tumor-infiltrating lymphocytes (TILs) in bone metastases are associated with their development, and unactivated T cells can increase bone resorption and the vicious cycle of bone metastases. Activated T cells, on the other hand, can suppress osteoclast formation. Furthermore, monocytic myeloid-derived suppressor cells (MDSCs) in bone metastases, expressing PD-L1, are potent suppressors of T cells. These findings suggest that immunotherapy may benefit bone metastases by activating T cells to inhibit bone resorption and metastasis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Karla Santacruz-Gomez, Rodrigo Melendrez, Marlen Licerio-Ramirez, Ana L. Gallego-Hernandez, Martin Pedroza-Montero, Ratnesh Lal
Summary: The actin cytoskeleton plays a crucial role in cancer cell metastasis. Plasmonic photothermal therapy mediated by PEGylated gold nanorods can disrupt the cytoskeleton integrity of HeLa cells and induce cell death through apoptosis.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Microbiology
Roberto Vazquez-Munoz, Angela Thompson, Jordan T. Russell, Takanori Sobue, Yanjiao Zhou, Anna Dongari-Bagtzoglou
Summary: In this study, the interactions between Lactobacillus johnsonii and Candida albicans were investigated. The results showed that L. johnsonii exhibited inhibitory effects on C. albicans growth, both in planktonic and biofilm states. These effects were influenced by pH and nutrient availability, and could be attributed to the production of soluble metabolites with anticandidal activity.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jorge L. Mejia-Mendez, Rafael Vazquez-Duhalt, Luis R. Hernandez, Eugenio Sanchez-Arreola, Horacio Bach
Summary: This review compiles recent scientific literature on virus-like particles (VLPs) with biomedical applications. It covers general information about viruses, the production and therapeutic performance of VLPs, the structural classification and functionalization methods of VLPs, and various characterization techniques for examining VLPs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Anaid Meza-Villezcas, Rommel A. Carballo-Castaneda, Aldo Moreno-Ulloa, Alejandro Huerta-Saquero
Summary: This study evaluated the changes in the metabolomic profile of Vibrio cholerae planktonic and biofilm cells in response to sublethal concentrations of silver nanoparticles (AgNPs). The results showed that more metabolites were significantly modulated in planktonic cells compared to biofilm cells. The chemical class profiles were distinct for both types of cells, indicating a phenotype-dependent metabolic response to the nanoparticles.
Article
Virology
Oscar Gonzalez-Davis, Maria V. Villagrana-Escareno, Mario A. Trujillo, Pedro Gama, Kanchan Chauhan, Rafael Vazquez-Duhalt
Summary: Enzyme replacement therapy (ERT) is used to treat diseases caused by enzyme deficiency. Encapsulation of enzymes inside virus-like particles (VLPs) as enzymatic nanoreactors provides a promising alternative for ERT. VLPs, as delivery vehicles, are biodegradable, organized, porous nanostructures that protect the biocatalyst and maintain its bioactivity. This article reviews the production processes and functionalization of virus-based enzymatic nanoreactors, and discusses their potential use in the treatment of lysosomal storage diseases and other genetic disorders.
Article
Chemistry, Multidisciplinary
Jorge A. Ontiveros-Robles, Francisca Villanueva-Flores, Karla Juarez-Moreno, Andrey Simakov, Rafael Vazquez-Duhalt
Summary: Copper oxide nanoparticles were functionalized with specific antibodies to enhance their antibacterial activity against Gram-positive or Gram-negative bacteria. The functionalized nanoparticles showed increased specificity of their antibacterial activity, as evidenced by the reduced IC50 and MI values in both Escherichia coli and Bacillus subtilis. The advantages of smart antibiotic nanoparticles are discussed.
Article
Microbiology
Roberto Vazquez-Munoz, Jordan. T. T. Russell, Angela Thompson, Yanjiao Zhou, Anna Dongari-Bagtzoglou
Summary: Lactobacillus johnsonii strain MT4, isolated from the oral cavity of C57BL/6 mice, exhibits antimicrobial activity against disease-associated microorganisms. The whole genome sequencing revealed a single genome of 1,883,026 bp with a GC content of 34.4%, and no plasmids.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Roberto Vazquez-Munoz, Angela Thompson, Takanori Sobue, Anna Dongari-Bagtzoglou
Summary: Oral bacteria can influence the virulence of Candida albicans in causing oropharyngeal candidiasis (OPC). A prebiotic diet enriched with xylo-oligosaccharides (XOS) can modulate the oral microbiome composition and attenuate Candida infection in an OPC mouse model.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemical Research Methods
Oscar Gonzalez-Davis, Itandehui Betanzo, Rafael Vazquez-Duhalt
Summary: This study presents a new spectrophotometric method for accurately determining the concentration of chitosan. The method involves the deamination of chitosan by nitrite under acidic conditions, followed by carbohydrate determination using the anthrone reagent.
BIOLOGY METHODS & PROTOCOLS
(2023)
Article
Chemistry, Multidisciplinary
M. J. Hernandez-Esparza, Ilaria Fratoddi, Sara Cerra, K. Juarez-Moreno, R. Huirache-Acuna
Summary: This research presents an evaluation of a hybrid material based on gold nanoparticles stabilized with 3-mercapto-propanesulfonate and loaded with methotrexate drug. The study demonstrates the effectiveness of the nanosystem in treating cervical cancer and melanoma, as well as its toxicity towards tumor cells.
NANOSCALE ADVANCES
(2023)
Article
Horticulture
Cristian Perez-Caselles, Nuria Alburquerque, Lydia Faize, Nina Bogdanchikova, Juan Carlos Garcia-Ramos, Ana G. Rodriguez-Hernandez, Alexey Pestryakov, Lorenzo Burgos
Summary: This study aimed to develop an effective protocol for apricot micropropagation and investigate the conditions for introducing silver nanoparticles (AgNPs) into apricot plants, as well as their effects on proliferation-related parameters. The results showed that the best micropropagation rate was achieved under specific culture conditions (40 initial shoots, 2 minutes of immersion every 6 hours, and 3 minutes of aeration every 3 hours). Furthermore, it was found that AgNPs can only be introduced into apricot plants when cultured in liquid media without chloride ions.
Meeting Abstract
Oncology
Danna L. Arellano, Patricia Juarez, Paloma S. Almeida-Luna, Felipe Olvera, Samanta Jimenez, Pierrick G. J. Fournier
CANCER IMMUNOLOGY RESEARCH
(2022)