Article
Sport Sciences
Jamie Pethick, Charlotte Casselton, Samantha L. Winter, Mark Burnley
Summary: The study found that ischemic preconditioning (IPC) can reduce the decrease in muscle torque complexity during fatigue at the neural level, leading to an extended time to task failure. IPC has an impact on the changes in EMG amplitude and oxygen consumption rate during muscle fatigue development.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Geriatrics & Gerontology
Jose D. Delgadillo, Christopher W. Sundberg, Minhyuk Kwon, Sandra K. Hunter
Summary: The study found that low-load resistance exercise with slow contractions induces greater muscle fatigability compared to traditional high-load resistance exercise, for both young and older men and women.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Physiology
Titouan Morin, Robin Souron, Ines Boulaouche, Marc Jubeau, Antoine Nordez, Lilian Lacourpaille
Summary: The purpose of this study was to determine whether mild to moderate muscle damage accumulates on the knee extensors after two bouts of maximal eccentric contractions performed over two consecutive days. The results showed that two days after the initial eccentric session, the experimental group had a higher strength deficit and an increase in muscle shear modulus compared to the control group.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, Aouatef Bellamine
Summary: The study indicates that L-carnitine tartrate supplementation can improve short-term recovery among athletes, while longer-term effects in the general population need further research. The experiment found that L-carnitine tartrate supplementation for 5 weeks could enhance perceived recovery and reduce soreness, as well as lower serum creatine kinase levels.
Article
Engineering, Biomedical
Manoel Silva, Arthur Gaspari, Joao Barbieri, Renato Barroso, Gabriel Figueiredo, Leonardo Motta, Antonio Moraes
Summary: The aim of this study was to determine if exposure to far-infrared (FIR) emitted by fabric can improve the neuromuscular performance of resistance-trained males' knee extensors regardless of temperature changes. The results showed that wearing FIR significantly increased muscle strength and total work, and the changes in temperature and electromyographic signals did not affect its effectiveness.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Anna Piotrowska, Wanda Pilch, Lukasz Tota, Marcin Maciejczyk, Dariusz Mucha, Monika Bigosinska, Przemyslaw Bujas, Szczepan Wiecha, Ewa Sadowska-Krepa, Tomasz Palka
Summary: Research showed that local vibration treatment after exercise can improve post-workout recovery by reducing the activity of creatine kinase (CK) and lactate dehydrogenase (LDH), thus decreasing markers of muscle fiber damage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Sport Sciences
Jordan B. Lee, William Lutz, Lucas J. Omazic, Mitchell A. Jordan, Joseph Cacoilo, Matthew Garland, Geoffrey A. Power, Philip J. Millar
Summary: Males have larger blood pressure responses to relative-intensity static handgrip exercise compared with females, but these differences can be abolished by controlling for absolute load (maximal voluntary contraction (MVC)). Sex differences in blood pressure responses during large muscle mass exercise or dynamic contractions vary depending on the intensity, and adjustments for absolute contraction intensity should be considered in cross-sectional comparisons of exercise blood pressure.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Biochemistry & Molecular Biology
Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi
Summary: Skeletal muscles generate force through myofiber contraction, which is transmitted to tendons. Studies on age-related changes in mouse muscles showed an increased dependence on longitudinal force transmission and a decreased efficiency in lateral force transmission in older muscles. There was an increase in connective tissue volume in the old muscles, but no significant change in dystrophin expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Liam Bagley, Nasser Al-Shanti, Steven Bradburn, Osamah Baig, Mark Slevin, Jamie S. McPhee
Summary: This study compared sex-related differences in knee extensor size, torque-velocity relationship, and fatigue resistance adaptations to 12-week SIT. The results showed that SIT significantly increased fatigue resistance and quadriceps muscle cross-sectional area similarly in men and women, but did not significantly affect torque in either gender.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Orthopedics
R. S. Husted, A. Troelsen, H. Husted, B. M. Gronfeldt, K. Thorborg, T. Kallemose, M. S. Rathleff, T. Bandholm
Summary: The study aimed to investigate the efficacy of different dosages of home-based knee-extensor resistance exercise in knee replacement patients and its impact on symptoms, physical function, and surgery decisions. The results showed no significant differences in isometric knee-extensor strength among the groups performing 2, 4, or 6 exercise sessions per week. Additionally, only one-third of the patients decided to undergo surgery after the exercise intervention.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Physiology
Samuel A. Smith, Dominic Micklewright, Samantha L. Winter, Alexis R. Mauger
Summary: The study found that muscle pain induced by hypertonic saline injection interfered with the accurate reproduction of knee extensor torque, which could have detrimental effects on exercise regulation and endurance performance. The experimental group showed significantly increased variance in mean contraction torque at both 15% and 20% MVIT, as well as performed target torques at a similar pain intensity.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Sigitas Kamandulis, Mantas Mickevicius, Audrius Snieckus, Vytautas Streckis, Diego Montiel-Rojas, Thomas Chaillou, Hakan Westerblad, Tomas Venckunas
Summary: By studying the effects of different rest intervals between repeated drop jumps, it was found that a longer rest interval helps to reduce the severity of DOMS rather than PLFFD. There were significant differences between the two protocols in terms of 20Hz torque depression and muscle soreness.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Jacob Frandsen, Ronni Eg Sahl, Tue Romer, Mikkel Thunestvedt Hansen, Andreas Blaaholm Nielsen, Michelle Munk Lie-Olesen, Hanne Kruuse Rasmusen, Ditte Sogaard, Arthur Ingersen, Mads Rosenkilde, Klaas Westerterp, Jens Juul Holst, Jesper Lovind Andersen, Adam Roman Markowski, Agnieszka Blachnio-Zabielska, Christoffer Clemmensen, Massimo Sacchetti, Angelo Cataldo, Marcello Traina, Steen Larsen, Flemming Dela, Jorn Wulff Helge
Summary: This study compared the metabolic and physiological changes in younger and older men after extreme endurance exercise. The results indicated that older individuals experienced a negative adaptive response in cardiovascular function, while both younger and older men showed a positive response in peripheral tissues.
Article
Nutrition & Dietetics
Emily C. Fraschetti, Lauren E. Skelly, Joel L. Prowting, Ali A. Abdul-Sater, Andrea R. Josse
Summary: High-intensity/impact exercise leads to an increase in inflammatory biomarkers, but consuming nutrient-dense wholefoods (such as milk) may help reduce post-exercise inflammation and aid recovery.
Article
Multidisciplinary Sciences
Georg Langen, Christine Lohr, Olaf Ueberschaer, Michael Behringer
Summary: This study aimed to investigate the reproducibility of different Vc concepts and the effect of different inter-stimuli intervals on Vc. The results showed that different Vc concepts displayed good to excellent relative and generally good absolute reliability, but the absolute reliability varied between different muscles. Moreover, the effect of different inter-stimuli intervals on Vc was unclear and further research is needed.
Article
Biochemistry & Molecular Biology
Marianna Kocsis, Alexandra Bodo, Tamas Koszegi, Rita Csepregi, Rita Filep, Gyula Hoffmann, Agnes Farkas
Summary: The goal of this study was to evaluate the pollen spectrum, antioxidant capacity, and mineral content of four types of Hungarian honey using multivariate statistical analysis. The results showed significant differences in pollen spectrum, antioxidant capacity, and mineral content among different types of honey, indicating their potential as markers for classification and identification of honey types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Evelin Patko, Edina Szabo, Denes Toth, Tamas Tornoczky, Inez Bosnyak, Alexandra Vaczy, Tamas Atlasz, Dora Reglodi
Summary: This study found widespread immunoreactivity of PACAP and its specific receptor PAC1-R in the human eye, indicating the translational value of in vitro and animal studies and suggesting their presence in the human eye. This is important for understanding the distribution and function of PACAP in the human eye.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Environmental Sciences
Eva Tekus, Nikolett Lilla Szenasi, Edina Szabo, Zoltan Heckel, Tibor Mintal, Tamas Koszegi, Tamas Atlasz, Zoltan Gazdag, Mark Vaczi, Marta Wilhelm
Summary: This study investigated the acute and chronic effects of a two-week eccentric concentric, dynamometric training on blood antioxidant parameters. The results showed that the training did not enhance the antioxidant defense or cause different time course of changes in muscle damage markers. Subjects may have already adapted to maintain constant levels of antioxidants and muscle torque due to their active lifestyle.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Agnes Farkas, Viktoria Lilla Balazs, Tamas Koszegi, Rita Csepregi, Erika Kerekes, Gyoergyi Horvath, Peter Szabo, Krisztian Gaal, Marianna Kocsis
Summary: The aim of this study was to assess the impact of four unifloral honeys on food-borne pathogens and analyze their antibacterial effects, biofilm degradation ability, antioxidant activity, and element content. The results showed that linden honey and chestnut honey had the best antibacterial and biofilm degradation effects and could be potential antimicrobial agents in food preservation.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Marin Gergics, Greta Pham-Dobor, Zoltan Horvath-Szalai, Tamas Koszegi, Emese Mezosi, Laszlo Bajnok
Summary: This study found that serum apelin levels were significantly decreased in short-term severe hypothyroidism, while copeptin levels remained unchanged. TSH and copeptin were independent predictors of apelin concentration, with TSH having a stronger impact.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Kitty Vadasz, Matyas Varga, Balazs Sebesi, Tibor Hortobagyi, Zsolt Murlasits, Tamas Atlasz, Adam Fesus, Mark Vaczi
Summary: This study examines the biomechanical mechanisms of knee and pelvis stabilization during unilateral vertical jumps. It found that hip abduction force does not directly regulate the magnitude of knee valgus, but the activation level of gluteus medius is crucial for increasing knee joint stability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Rita Jakabfi-Csepregi, Gabor L. Kovacs, Peter Kaltenecker, Tamas Koszegi
Summary: We developed a novel multiplexed high throughput method for protein expression analysis that can directly analyze 25,000-100,000 cells in 96-well plates with a daily capacity of 180 tests. Our assay simultaneously quantifies 22 protein antigens with an interassay imprecision below 10% CV. The results show that ochratoxin A increased the expression of various proteins, while staurosporine decreased the expression of certain proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sandor Pentek, Akos Varnagy, Balint Farkas, Peter Mauchart, Krisztina Godony, Timea Varjas, Tamas Koszegi, Peter Kaltenecker, Rita Jakabfi-Csepregi, Kalman Kovacs, Jozsef Bodis, Endre Sulyok
Summary: This study aimed to investigate the relationship between telomere length, telomerase activity, and oxidative DNA damage in IVF patients. The study found that telomere lengths were similar in granulosa cells and follicular fluid, but telomerase activity was significantly reduced and 8-OHdG levels were significantly elevated in follicular fluid. Additionally, high levels of 8-OHdG were associated with negative outcomes in IVF success and clinical pregnancies.
Article
Biochemistry & Molecular Biology
Zoltan Horvath-Szalai, Rita Jakabfi-Csepregi, Balazs Szirmay, Daniel Ragan, Gerda Simon, Zoltan Kovacs-Abraham, Peter Szabo, David Sipos, Agnes Peterfalvi, Attila Miseta, Csaba Csontos, Tamas Koszegi, Ildiko Toth
Summary: In this study, the predictive value of serum non-enzymatic total antioxidant capacity (TAC) and the newly introduced TAC/lymphocyte ratio in COVID-19 was elucidated. The results showed that both TAC and TAC/lymphocyte ratio could provide valuable information regarding the severity of COVID-19, and TAC served as a promising marker for predicting systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Balazs Sagi, Tibor Vas, Rita Jakabfi-Csepregi, Zoltan Horvath-Szalai, Tamas Koszegi, Botond Csiky, Judit Nagy, Tibor Jozsef Kovacs
Summary: The study aimed to find different biomarkers to estimate the outcome of chronic kidney disease (CKD) and IgA nephropathy (IgAN), which are influenced by changes in vessels and the heart. The findings showed higher levels of NT-proBNP and cfPWV in patients with CKD 3-5 compared to CKD 1-2. NT-proBNP and CITP biomarkers play an important role in identifying IgAN patients at risk for subclinical heart failure and atherosclerotic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Csilla Kurdi, Vanessza Lelovics, David Hesszenberger, Aniko Lajtai, Agnes Lakatos, Robert Herczeg, Krisztina Godony, Peter Mauchart, Akos Varnagy, Gabor L. Kovacs, Tamas Koszegi
Summary: The global prevalence of insulin resistance (IR) is increasing, with negative effects on metabolic parameters and fertility. This study quantitatively determined the amino acid profile of follicular fluid (FF) in insulin-resistant and non-insulin-resistant (NIR) groups and found significant differences in several amino acids between the two groups. The most significant alterations were related to the glutathione metabolic pathway. This suggests that insulin resistance can lead to changes in amino acid composition in FF, resulting in poor oocyte quality and reduced fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Levente Tyukodi, Balazs Zoltan Zsido, Csaba Hetenyi, Tamas Koszegi, Imre Huber, Zsuzsanna Rozmer
Summary: In this study, the binding nature of three selected synthetic cyclic C5-curcuminoid derivatives to human serum albumin (HSA) at different temperatures was investigated using UV-Vis absorption spectroscopy, fluorescence methods, and 3D molecular modeling simulation. The experimental results revealed that the compounds formed complexes with HSA, leading to fluorescence quenching through a predominantly static quenching process with a quenching constant in the range of 104-105 M-1. The binding constants, binding sites, and thermodynamic parameters were calculated, suggesting that hydrophobic forces played a major role in the interaction between curcuminoids and HSA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Tamas Koszegi, Zoltan Horvath-Szalai, Daniel Ragan, Brigitta Kosa, Balazs Szirmay, Csilla Kurdi, Gabor L. Kovacs, Diana Muhl
Summary: A competitive fluorescence ELISA method for measuring urinary Gc-globulin (u-Gc) levels has been developed and validated. Elevated u-Gc/u-creatinine levels are associated with septic acute kidney injury (AKI), and show correlation with the severity of AKI.
Article
Medicine, General & Internal
Marin Gergics, Greta Pham-Dobor, Csilla Kurdi, Gergely Montsko, Krisztina Mihalyi, Gabor Banfai, Peter Kanizsai, Tamas Koszegi, Emese Mezosi, Laszlo Bajnok
Summary: In this prospective observational study, the researchers investigated the prognostic role of apelin-13 in critically ill patients and explored its correlations with free cortisol, aldosterone, CRH, and copeptin. The results showed a strong positive correlation between apelin-13 and CRH concentrations, and apelin-13 was significantly higher in non-septic patients. Multivariate Cox regression analysis revealed that apelin-13 and free cortisol were independent determinants of survival.
JOURNAL OF CLINICAL MEDICINE
(2023)