Article
Biochemistry & Molecular Biology
Diana Duarte, Mariana Nunes, Sara Ricardo, Nuno Vale
Summary: Drug combination and repurposing strategies have been shown to be effective and cost-saving in finding new cancer therapies. This study demonstrates significant cytotoxicity of certain drug combinations in breast cancer and colorectal adenocarcinoma cells, while being safe for non-tumoral cells. Additionally, the study suggests a potential role of PPT1 in the mechanisms of action of these drug combinations.
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Chen Tang, Shaliu Fu, Xuan Jin, Wannian Li, Feiyang Xing, Bin Duan, Xiaojie Cheng, Xiaohan Chen, Shuguang Wang, Chenyu Zhu, Gaoyang Li, Guohui Chuai, Yayi He, Ping Wang, Qi Liu
Summary: In this study, researchers present comboSC, a computational proof-of-concept study that explores the feasibility of personalized cancer combination therapy optimization using single-cell transcriptomes. The comboSC method allows for the evaluation of personalized immune microenvironments and the identification of synergistic drug combinations or small molecules paired with immune checkpoint inhibitors for personalized cancer treatment.
Review
Biochemical Research Methods
Betul Guvenc Paltun, Samuel Kaski, Hiroshi Mamitsuka
Summary: Drug combination therapy is a promising strategy for treating complex diseases, especially in cancer patients where knowledge is limited. Machine learning methods offer an effective way to improve therapeutic efficacy and overcome drug resistance. Data integration and experimental comparisons play a crucial role in drug combination analysis.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Rachele Rossi, Maria Laura De Angelis, Eljona Xhelili, Giovanni Sette, Adriana Eramo, Ruggero De Maria, Ursula Cesta Incani, Federica Francescangeli, Ann Zeuner
Summary: Lung cancer is a highly complex disease with significant heterogeneity among patients. Organoids generated from lung tumors are valuable tools in cancer research as they can replicate individual tumor characteristics and aid in the study of the disease and the identification of effective therapies.
Review
Chemistry, Multidisciplinary
Min Huang, Mei-yu Geng, Jian Ding
Summary: Anticancer drug discovery has made unprecedented progress in recent decades, contributing to innovative treatment options for patients and the implementation of personalized medicine. This article pays tribute to cancer research at Shanghai Institute of Materia Medica, providing an overview of the conceptual revolution in anticancer therapy and summarizing recent progress in molecularly targeted therapeutics and exploration of new strategies in personalized medicine.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Microbiology
Sania Batool, Santosh Chokkakula, Min-Suk Song
Summary: Influenza infection is a serious health concern due to the constant mutation and recombination of the influenza virus. This makes it difficult to eliminate the disease and treatment challenging. Combination therapy with multiple antivirals or immunomodulators is considered the best strategy for effectively treating influenza infection. This review discusses the current options for combination therapy, their performance, and the limitations imposed by drug resistance.
Review
Chemistry, Medicinal
Wei Zhao, Xiao-Di Zheng, Paula Yun-Zhi Tang, Hong-Mei Li, Xue Liu, Jian-Jiang Zhong, Ya-Jie Tang
Summary: The antitumor efficacy of Chinese herbal medicines has been widely recognized. However, their clinical applications were limited by low bioavailability, significant toxicity, and side effects. Recent studies have focused on designing and synthesizing new chemical entities by combining natural drugs with other small molecules to enhance the antitumor activity and reduce side effects. The development of antitumor conjugates based on Chinese herbal medicine is expected to greatly shorten the drug research and development process and provide valuable references for clinical applications.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Immunology
Renjie Wang, Kairong Xiong, Zhimin Wang, Di Wu, Bai Hu, Jinghan Ruan, Chaoyang Sun, Ding Ma, Li Li, Shujie Liao
Summary: Immunotherapy has shown significant effectiveness in various types of cancer, but the majority of patients do not benefit from it. Evaluating tumor heterogeneity and immune status before treatment is crucial for identifying patients who are more likely to respond to immunotherapy. Demographic characteristics, immune status, and specific biomarkers all play a role in the response to immunotherapy. An integrated immunodiagnostic model utilizing artificial intelligence could provide valuable information for predicting treatment response. We introduce the concept of immunodiagnosis as the blueprint for this model, discuss the features it should include, and outline the strategy for constructing it. Furthermore, we explore the potential incorporation of this immunodiagnosis model in clinical practice in order to improve the prognosis of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Bessi Qorri, Reza Bayat Mokhtari, William W. Harless, Myron R. Szewczuk
Summary: Drug repurposing in combination with clinical standard chemotherapeutics opens a novel and promising clinical treatment approach for patients with pancreatic cancer. The combination of aspirin and oseltamivir phosphate with chemotherapeutic gemcitabine shows a therapeutic effect on pancreatic cancer cells, modulating cell proliferation, invasion, clonogenicity, and migration.
Article
Computer Science, Information Systems
Fei Wang, Yulian Ding, Xiujuan Lei, Bo Liao, Fang-Xiang Wu
Summary: The study introduces a new drug repositioning approach (HDgS) that utilizes human protein complexes to define drug signatures, effectively identifying drug candidates for patients and adaptable for personalized medicine.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Oncology
Zhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang
Summary: This research established an effective three-dimensional culture system for generating kidney cancer organoids and successfully generated 33 organoid lines from different subtypes of kidney cancer. These organoids preserved the histological architecture, mutational landscape, and transcriptional profile of the parental tumor tissues, and revealed inter- and intra-tumoral heterogeneity. Additionally, the organoids can be used for drug screening and evaluating the efficacy of immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Slavica Lazarevic, Maja Danic, Hani Al-Salami, Armin Mooranian, Momir Mikov
Summary: Despite the increasing number of new drugs, conventional drugs like azathioprine still play a valuable role in the treatment of inflammatory bowel disease (IBD). The gut microbiota has the ability to affect drug metabolism and alter clinical effectiveness, especially for complex drugs like azathioprine. This study explores the microbiota-mediated metabolism of azathioprine and provides insights for personalized thiopurine treatment of IBD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Yuqiao Liu, Junmin Li, Shenghao Xiao, Yanhui Liu, Mingxia Bai, Lixiu Gong, Jiaqian Zhao, Dajing Chen
Summary: Precision medicine is essential for optimizing drug dosage and minimizing toxicity. Wearable sensors offer real-time and continuous drug monitoring, enabling personalized medicine and reducing healthcare costs.
Article
Pharmacology & Pharmacy
Hellen Windolf, Rebecca Chamberlain, Joerg Breitkreutz, Julian Quodbach
Summary: Treating Parkinson's disease is challenging, and personalized therapy is crucial due to specific requirements of drug therapy. This study utilized 3D printing to create personalized medication, including both rapid and prolonged drug release formulations, to meet the varying drug release needs. This provides a more personalized and effective treatment option for patients with Parkinson's disease.
Review
Respiratory System
John Paul Clancy, Calvin U. Cotton, Scott H. Donaldson, George M. Solomon, Donald R. VanDevanter, Michael P. Boyle, Martina Gentzsch, Jerry A. Nick, Beate Illek, John C. Wallenburg, Eric J. Sorscher, Margarida D. Amaral, Jeffrey M. Beekman, Anjaparavanda P. Naren, Robert J. Bridges, Philip J. Thomas, Garry Cutting, Steven Rowe, Anthony G. Durmowicz, Martin Mense, Kris D. Boeck, William Skach, Christopher Penland, Elizabeth Joseloff, Hermann Bihler, John Mahoney, Drucy Borowitz, Katherine L. Tuggle
JOURNAL OF CYSTIC FIBROSIS
(2019)
Review
Otorhinolaryngology
Turang E. Behbahani, Eben L. Rosenthal, William B. Parker, Eric J. Sorscher
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Developmental Biology
Z. E. Plyler, S. E. Birket, B. D. Schultz, J. S. Hong, S. M. Rowe, C. F. Petty, M. R. Crowley, D. K. Grossman, T. R. Schoeb, E. J. Sorscher
MECHANISMS OF DEVELOPMENT
(2019)
Editorial Material
Multidisciplinary Sciences
Candela Manfredi, Janice M. Tindall, Jeong S. Hong, Eric J. Sorscher
Article
Biotechnology & Applied Microbiology
Christine Polte, Daniel Wedemeyer, Kathryn E. Oliver, Johannes Wagner, Marcel J. C. Bijvelds, John Mahoney, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
Article
Cell Biology
Guiying Cui, Jeong Hong, Yu-Wen Chung-Davidson, Daniel Infield, Xin Xu, Jindong Li, Luba Simhaev, Netaly Khazanov, Brandon Stauffer, Barry Imhoff, Kirsten Cottrill, J. Edwin Blalock, Weiming Li, Hanoch Senderowitz, Eric Sorscher, Nael A. McCarty, Amit Gaggar
DEVELOPMENTAL CELL
(2019)
Article
Medicine, Research & Experimental
Kathryn E. Oliver, Robert Rauscher, Marjolein Mijnders, Wei Wang, Matthew J. Wolpert, Jessica Maya, Carleen M. Sabusap, Robert A. Kesterson, Kevin L. Kirk, Andras Rab, Ineke Braakman, Jeong S. Hong, John L. Hartman, Zoya Ignatova, Eric J. Sorscher
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Guiying Cui, Brandon B. Stauffer, Barry R. Imhoff, Andras Rab, Jeong S. Hong, Eric J. Sorscher, Nael A. McCarty
SCIENTIFIC REPORTS
(2019)
Article
Oncology
William B. Parker, Paula W. Allan, William R. Waud, Jeong Hong, Melissa Gilbert-Ross, B. R. Achyut, Disha Joshi, Turang Behbahani, Regina Rab, Steven E. Ealick, Eric J. Sorscher
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Article
Respiratory System
Giovana B. Bampi, Robert Rauscher, Sebastian Kirchner, Kathryn E. Oliver, Marcel J. C. Bijvelds, Leonardo A. Santos, Johannes Wagner, Raymond A. Frizzell, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Biotechnology & Applied Microbiology
Shingo Suzuki, Ana M. Crane, Varada Anirudhan, Cristina Barilla, Nadine Matthias, Scott H. Randell, Andras Rab, Eric J. Sorscher, Jenny L. Kerschner, Shiyi Yin, Ann Harris, Matthew Mendel, Kenneth Kim, Lei Zhang, Anthony Conway, Brian R. Davis
Article
Critical Care Medicine
Susan E. Birket, Joy M. Davis, Courtney M. Fernandez-Petty, Alexander G. Henderson, Ashley M. Oden, LiPing Tang, Hui Wen, Jeong Hong, Lianwu Fu, Andre Chambers, Alvin Fields, Gojun Zhao, Guillermo J. Tearney, Eric J. Sorscher, Steven M. Rowe
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Robert Rauscher, Giovana B. Bampi, Marta Guevara-Ferrer, Leonardo A. Santos, Disha Joshi, David Mark, Lisa J. Strug, Johanna M. Rommens, Manfred Ballmann, Eric J. Sorscher, Kathryn E. Oliver, Zoya Ignatova
Summary: Epistasis is a phenomenon where mutations depend on each other and the genetic context. In the case of cystic fibrosis, positive epistasis was observed between intragenic mutations in the CFTR gene, enhancing protein expression and activity. Functional studies revealed that alteration in ribosomal velocity is the underlying mechanism for this synergy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Regina Rab, Annette Ehrhardt, Bhagelu R. Achyut, Disha Joshi, Melissa Gilbert-Ross, Chunzi Huang, Katharine Floyd, Anton Borovjagin, William B. Parker, Eric J. Sorscher, Jeong S. Hong
Summary: This study investigated the feasibility of using PNP gene transfer for the treatment of head and neck malignancies, utilizing recombinant adenovirus and patient-derived xenografts. The results demonstrated that the PNP approach effectively inhibited the proliferation of malignant tumor cells and produced significant anticancer effects. Additionally, specific adenovirus receptors were found to be highly expressed in human tumor models, and a vector utilizing this pathway was evaluated.