期刊
ORGANIC LETTERS
卷 21, 期 23, 页码 9391-9395出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03615
关键词
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资金
- National Natural Science Foundation of China [21625204, 21790332, 21532003, 21971119]
- 111 project of the Ministry of Education of China [B06005]
- National Program for Special Support of Eminent Professionals
A highly efficient asymmetric Michael addition of thiols to exocyclic enones was achieved by using chiral Spiro phosphoramide catalysts. The precisely chiral control in the protonation of the enol intermediate ensured high enantioselectivity. The reaction features high activity (yields up to 99%, turnover numbers up to 8400) and high enantioselectivity (up to 97% ee) with a broad substrate scope, and it has the potential for wide application in the synthesis of chiral sulfides.
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