期刊
ORGANIC LETTERS
卷 21, 期 22, 页码 8915-8920出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03147
关键词
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资金
- National Natural Science Foundation of China [NSFC21572272]
- Foundation of The Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX201818, CPU2018GY3S, CPU2018GY04]
An unprecedented nickel-catalyzed reductive 1,2-dialkynylation of alkenes bearing an 8-aminoquinoline directing group has been developed. This method proceeded through a migratory insertion/reductive-coupling process under mild conditions with a wide substrate scope and good functional group tolerance, providing direct access to the synthetically flexible 1,5-diynes. Moreover, the 1,2-dialkynylation products could be further converted to borate-ester- or azide-functionalized 1,5-dienes, ditriazole, beta-diyne primary amide, and trisubstituted benzene.
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