期刊
ORGANIC LETTERS
卷 21, 期 22, 页码 8921-8924出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03174
关键词
-
资金
- National Natural Science Foundation of China [21572226, 21772196]
- Dalian Science and Technology Innovation Project [2018J12GX054]
A catalytic asymmetric hydrogenation of beta-phosphorylated enamides for enantioselective access to optically active beta-aminophosphine derivatives is reported. Critical to the success of this method was the employment of rhodium catalysis in concert with an unsymmetrical hybrid chiral phosphine-phosphoramidite ligand. A wide range of aromatic beta-phosphorylated enamides could be hydrogenated in full conversion and with perfect enantioselectivity even at low catalyst loadings (S/C = 1000). beta-Aminophosphine oxides could be readily hydrolyzed and reduced, thus providing an efficient route to catalytically important chiral beta-aminophosphines.
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