期刊
ORAL ONCOLOGY
卷 98, 期 -, 页码 92-95出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2019.09.024
关键词
Lin28; Lin28/let-7; PD-L1; Head and neck cancer; Squamous cell carcinoma; Development; Cell reprogramming; Cancer stem cell; Stem cell therapy; Immunotherapy
资金
- Wuhan Morning Light Plan of Youth Science and Technology [2017050304010305]
- National Natural Science Foundation of China [81702705]
Lin28, a highly conserved RNA-binding protein, plays an important role in differentiation, metabolism, proliferation, pluripotency, and tumourigenicity. Lin28 overexpression promotes tumour-cell proliferation and metastasis in various human cancers, including head and neck cancer. Multiple studies demonstrate that Lin28 critically contributes to anti-tumour immunity and production of cancer stem cells in head and neck squamous cell carcinoma (HNSCC). Thus, Lin28 has potential application in HNSCC treatment.
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