Article
Gastroenterology & Hepatology
Lan Yu, Yanwei Gao, Beibei Ji, Zongqi Feng, Tianfang Li, Wei Luan
Summary: LINC01207 is highly expressed in gastric cancer tissues and cells, acting as a ceRNA to upregulate PODXL by sponging miR-1301-3p, promoting cell proliferation and migration while inhibiting apoptosis. CTCF transcriptionally activates LINC01207 to contribute to gastric cancer progression.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Obstetrics & Gynecology
Huiping Yao, Rui Chen, Yongxiu Yang, Juan Jiang
Summary: The study revealed that high expression of BBOX1-AS1 in ovarian cancer tissues and cells, and silencing BBOX1-AS1 inhibited OC cell proliferation and promoted apoptosis. BBOX1-AS1 was shown to regulate PODXL through miR-361-3p, exerting carcinogenic effects on OC cell growth.
REPRODUCTIVE SCIENCES
(2021)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Yong-Sheng Chen, Yong-Peng Xu, Wen-Hua Liu, De-Chao Li, Huan Wang, Chang-Fu Li
Summary: In this study, we identified the elevated expression of KCNMB2-AS1 in bladder cancer for the first time and demonstrated that KCNMB2-AS1 mediated bladder cancer progression by regulating the miR-3194-3p/SAMD5 signaling pathway. These findings provide a novel target for bladder cancer research.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Junqing Chen, Ling Cheng, Weibin Zou, Rong Wang, Xiaojia Wang, Zhanhong Chen
Summary: The study reveals that ADAMTS9-AS1 can inhibit the progression of breast cancer by sequestering miR-301b-3p, involving the TGFBR2/JAK STAT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiufang Yang, Huilan Du, Wenhui Bian, Qingxue Li, Hairu Sun
Summary: This study demonstrated that FOXD3-AS1 is upregulated in cervical cancer tissues and cells, promoting cell proliferation, migration, and invasion. High FOXD3-AS1 expression is associated with poor tumor differentiation, increased tumor size, and lymph node metastasis. FOXD3-AS1 directly targets miR-128-3p, leading to upregulation of LIMK1 expression in cervical cancer cells, thus facilitating cervical cancer progression.
Article
Biotechnology & Applied Microbiology
Fenfen Wang, Zhengyuan Xie, Nuobei Zhang, Hao Ding, Kai Xiong, Li Guo, Hongyan Huang, Zhili Wen
Summary: The study found that hsa_circ_0008583 promotes the progression of hepatocellular carcinoma through the miR-1301-3p/METTL3 axis, specifically by promoting cell proliferation, migration, and invasion.
Article
Oncology
Yue Jiang, Xiangpan Li, Yu Yang, Jiajun Luo, Xunshan Ren, Jingwen Yuan, Qiang Tong
Summary: This study found that HOXC-AS1 is overexpressed in gastric cancer and is associated with poor prognosis. Silencing HOXC-AS1 significantly inhibits the proliferation of gastric cancer cells. HOXC-AS1 promotes the progression of gastric cancer cells by sponging miR-99a-3p and upregulating MMP8.
Article
Medicine, Research & Experimental
Min Wu, Yi Liu, Yan-Song Pu, Yu Ma, Jian-Hua Wang, En-Qi Liu
Summary: The study revealed that high expression of JHDM1D-AS1 in gastric cancer is associated with tumor progression, affecting cell proliferation and invasion through regulation of the miR-450a-2-3p/PRAF2 axis.
Article
Oncology
Dakui Luo, Hao Fan, Xiang Ma, Chao Yang, Yu He, Yugang Ge, Mingkun Jiang, Zekuan Xu, Li Yang
Summary: Existing evidence strongly suggests that miR-1301-3p plays a significant role in the tumorigenesis and progression of gastric cancer. The overexpression of miR-1301-3p in GC tissues and cells accelerates cell proliferation, cell cycle progression, and tumorigenesis. SIRT1 is identified as a direct target of miR-1301-3p, and knockdown of SIRT1 enhances the proliferative ability of GC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Yuliang Qu, Dan Jiang, Minjuan Liu, Hongxia Wang, Tao Xu, Haijin Zhou, Minlan Huang, Weitong Shu, Guangxian Xu
Summary: Tuberculosis is caused by Mycobacterium tuberculosis and lncRNA DANCR promotes autophagy by sponging miR-1301-3p and miR-5194, thus inhibiting the intracellular survival of M. tuberculosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Otorhinolaryngology
De-hui Qiao, Xue-mei He, Hui Yang, Yang Zhou, Xian Deng, Lian Cheng, Xiang-yu Zhou
Summary: The study revealed that miR-1301-3p expression was significantly decreased in thyroid papillary carcinoma (PTC), and upregulation of miR-1301-3p could inhibit cell proliferation and migration, potentially serving as a biomarker for early diagnosis and treatment of PTC.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Oncology
Chenming Zhong, Yiyao Dong, Qiudan Zhang, Chunhui Yuan, Shiwei Duan
Summary: miR-1301 is a newly discovered miRNA that is abnormally expressed in multiple types of tumors and is associated with various aspects of tumor progression. Its abnormal expression is correlated with poor prognosis in cancer patients. Additionally, miR-1301 is involved in the anti-tumor effects of certain drugs and can enhance the sensitivity of certain tumors to specific drugs. This study summarizes the expression and functions of miR-1301 in cancer and provides potential directions for future research.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Siyeon Jang, Hyeonjin Lee, Seung-Hoon Yang, Beom Seok Kwak, Sun Jung Kim
Summary: This study identifies the role of the ELOVL2-AS1/ELOVL2/miR-1233-3p signaling pathway in drug resistance in Tam-resistant breast cancer, suggesting its potential as a target for therapy.
Article
Multidisciplinary Sciences
Houmin Wan, Lianzhen Wang, Bin Huo, Zhongpeng Qiao, Yingli Zhang
Summary: CIZ1 functions as a tumor promoter in gastric cancer and its expression is regulated by FBXL19-AS1 and miR-339-3p. Silencing CIZ1 attenuates the malignant phenotype of gastric cancer cells. miR-339-3p has a negative role in gastric cancer development and depletion of FBXL19-AS1 also inhibits gastric cancer progression.
Article
Cell Biology
Pengfei Xia, Qing Li, Guanlin Wu, Yimin Huang
Summary: In this study, immune-related lncRNAs in glioma were identified by analyzing RNA-seq data from TCGA and CGGA. A risk score formula was constructed to predict overall survival, with high-risk patients showing poorer survival in both datasets. The formula demonstrated better predictive power compared to current clinical data, providing potential therapeutic targets and guidance for glioma pathogenesis and treatment.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guanlin Wu, Pengfei Xia, Shixian Yan, Dongming Chen, Lei Xie, Gang Fan
Summary: In this study, through weighted gene coexpression network analysis, five hub lncRNAs were identified as potential biomarkers for the progression and prognosis of chromophobe renal cell carcinoma.
PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Guanlin Wu
CLINICAL AND INVESTIGATIVE MEDICINE
(2019)
Article
Oncology
Guanlin Wu, Jian Wang, Guojun Chen, Xing Zhao
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)