期刊
NEUROSURGERY CLINICS OF NORTH AMERICA
卷 30, 期 4, 页码 473-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2019.05.006
关键词
Recurrent pituitary tumor; KNOSP grade; Transsphenoidal surgery; Pituitary adenomas
Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.
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