Article
Endocrinology & Metabolism
Sinisa Cikic, Partha K. Chandra, Jarrod C. Harman, Ibolya Rutkai, Prasad V. G. Katakam, Jessie J. Guidry, Jeffrey M. Gidday, David W. Busija
Summary: The study identified sexual dimorphism in mitochondrial metabolic protein profiles of cerebral microvessels, with females expressing more proteins involved in energy production, antioxidant defense, and fatty acid oxidation, while males had higher expression levels of mitochondria-destructive proteins. These differences may contribute to sex-dependent cerebrovascular and neurological pathologies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yu-Huan Gu, Brian T. Hawkins, Yoshikane Izawa, Yoji Yoshikawa, James A. Koziol, Gregory J. del Zoppo
Summary: A study found that anti-thrombin activity decreases the risk of intracerebral hemorrhage by inhibiting thrombin-mediated degradation of cerebral microvessel basal lamina matrix. This has implications for understanding focal ischemia and other related conditions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Ayan Mohamud Yusuf, Nina Hagemann, Sarah Schulten, Olessja Rausch, Kristina Wagner, Tanja Hussner, Yachao Qi, Matthias Totzeck, Christoph Kleinschnitz, Anthony Squire, Matthias Gunzer, Dirk M. Hermann
Summary: The advancement of light sheet microscopy enables 3D analysis of cerebral microvasculature in cleared brains. The technique of reverse clearing and rehydration allows for immunohistochemistry in cleared brains. Microvascular remodeling in the early phase after stroke shows reduced branching point density.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Veterinary Sciences
Wei Zhao, Jialei Shi, Yongxiu Yao, Hongxia Shao, Aijian Qin, Kun Qian
Summary: This study successfully isolated and molecularly characterized two strains of Chicken astrovirus (CAstV), and observed their effect on hatchability. The genetic analysis showed that these two strains had typical characteristics of avian astroviruses, with high similarity among Chinese strains and a common origin with strains from the UK.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Paul Varava, Zhaowen Dong, Rosario Scopelliti, Farzaneh Fadaei-Tirani, Kay Severin
Summary: Diazoolefins are highly reactive compounds that rapidly lose dinitrogen, and are observed to form in reactions of N-heterocyclic olefins with nitrous oxide. They display resonance stabilization, strong ylidic character, and good thermal stability, despite the presence of terminal N-2 groups. Diazoolefins can bind metal complexes without liberating dinitrogen and are strong electron donors, while also undergoing reactions involving the N-2 group.
Article
Chemistry, Multidisciplinary
Kevin Pfeifer, Eva-Kathrin Ehmoser, Simon K-M R. Rittmann, Christa Schleper, Dietmar Pum, Uwe B. Sleytr, Bernhard Schuster
Summary: The outermost component of cell envelopes in most bacteria and almost all archaea is a protein lattice called Surface (S-) layer, which has a highly porous structure with regularly arranged pores in the nm-range. The S-layer fragments of a hyperthermophilic acidophilic archaeon SSO show high retention efficiency and reduced extraction costs, making them economically attractive.
Review
Chemistry, Applied
Luxsika Ngamwonglumlert, Sakamon Devahastin
Summary: This review provides a systematic presentation and discussion on the chemistry and use of brazilein in foods for the first time. It covers the processes of isolation, purification, and quantification, as well as the molecular structure, color stabilities, and methods to enhance stability of the pigment. The review also highlights selected applications of brazilein in foods and suggests that future studies should focus on isolating and purifying the pigment and enhancing its stability.
Article
Biochemistry & Molecular Biology
Tongrong He, Livius V. d'Uscio, Zvonimir S. Katusic
Summary: This study found that BACE2, which is highly expressed in cerebrovascular endothelium, plays a role in controlling the expression and function of eNOS. Downregulation of BACE2 led to decreased expression of eNOS and reduced production of nitric oxide, while overexpression of APP increased eNOS expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Nuwan Gunarathna, Anjalie Amarasinghe, Sunil Wijesundara, Devika Iddawela, Susiji Wickramasinghe
Summary: This study determined the presence and prevalence of Naegleria species in the water bodies of North-Western Province of Sri Lanka through molecular characterization and phylogenetic analysis. The prevalence of Naegleria species and N. fowleri in the study area were 23.07% and 1.92%. Bayesian analysis revealed different clade formations among the isolates, indicating the need for further investigations to confirm these findings.
Article
Chemistry, Applied
Qiulian Shen, Liping Sun, Zedong He, Jinxiang Xie, Yongliang Zhuang
Summary: This study purified umami peptides from wild Lactarius volemus and identified their umami taste features and binding sites. The findings contribute to a better understanding of the tasty flavor of Lactarius volemus.
Article
Multidisciplinary Sciences
Conrad A. P. Goodwin, Jing Su, Lauren M. Stevens, Frankie D. White, Nickolas H. Anderson, John D. Auxier, Thomas E. Albrecht-Schonzart, Enrique R. Batista, Sasha F. Briscoe, Justin N. Cross, William J. Evans, Alyssa N. Gaiser, Andrew J. Gaunt, Michael R. James, Michael T. Janicke, Tener F. Jenkins, Zachary R. Jones, Stosh A. Kozimor, Brian L. Scott, Joseph. M. Sperling, Justin C. Wedal, Cory J. Windorff, Ping Yang, Joseph W. Ziller
Summary: This study revives air-/moisture-sensitive Californium chemistry through the synthesis and characterization of an organometallic complex, providing new insights into Californium chemistry with its unique structural features.
Article
Food Science & Technology
Dongwei Xiong, Jun Wen, Gen Lu, Tianxi Li, Miao Long
Summary: In this study, a strain of Bacillus amyloliquefaciens B10 with a strong ability to degrade aflatoxin B1 (AFB1) was screened. A new laccase with AFB1-degrading activity was separated and its optimal temperature and pH for AFB1 degradation were determined. Metal ions and a solvent were found to enhance the AFB1-degrading activity of the laccase.
Article
Chemistry, Applied
Yue Zhang, Xinchang Gao, Daodong Pan, Zhiguo Zhang, Tianqiong Zhou, Yali Dang
Summary: Fourteen novel umami peptides were isolated and identified from Ruditapes philippinarum, with KSAEN and QIEELEGK having higher sensory evaluations, and PAATIPE and HNESQN showing the best umami-enhancing taste in a 0.35% MSG solution. Molecular docking showed that certain amino acids may play important roles in the interaction of peptides with taste receptors, contributing to the umami taste of the shellfish.
Article
Biotechnology & Applied Microbiology
Shigeki Oogai, Masakazu Fukuta, Masashi Inafuku, Hirosuke Oku
Summary: Leucaena leucocephala is a potential forage for livestock due to its rich protein, fiber, and minerals. However, the presence of toxic nonprotein amino acid mimosine hinders its use as livestock feed. In this study, a microorganism called Arthrobacter sp. Ryudai-S1 was isolated from the soil surrounding L. leucocephala trees, which can degrade and assimilate mimosine as a nitrogen and carbon source. The mimosinase in this strain was found to be thermostable and showed strong activity. Further analysis identified key amino acid residues that play a critical role in substrate binding and catalytic efficacy. These findings suggest that Arthrobacter sp. Ryudai-S1 could be potentially useful for developing L. leucocephala feed with reduced mimosine content.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gizem Aytogu, Eda B. Toker, Ozkan Yavas, Berfin Kadiroglu, Ozer Ates, Musa Ozgur Ozyigit, Kadir Yesilbag
Summary: This article reports the first clinical case of pseudorabies in a hunting dog in Bursa province, Turkey. The virus was successfully isolated and characterized from the tissue samples. The study confirms the possible presence of pseudorabies infection in wildlife reservoirs in Turkey.
MOLECULAR BIOLOGY REPORTS
(2022)