Article
Multidisciplinary Sciences
Jintao Sheng, Liang Zhang, Chuqi Liu, Jing Liu, Junjiao Feng, Yu Zhou, Huinan Hu, Gui Xue
Summary: Episodic memory allows humans to encode and retrieve information about experiences. The human brain maintains a high-dimensional representation of faces to support accurate episodic memory. Greater dimensionality is associated with better memory performance. Frontoparietal activities can increase dimensionality and reduce correlations of local neural responses.
Article
Biology
Juan Martinez-Cervantes, Prachi Shah, Anna Phan, Isaac Cervantes-Sandoval, Sonia Sen
Summary: This study reports the sensory preconditioning in fruit flies and the mechanisms that regulate this process. The results show that fruit flies can infer value to olfactory stimuli based on previous associations between odors, and that inhibition of a specific regulator can lengthen the time window of the olfactory 'sensory buffer', allowing the establishment of associations between sequentially presented odors.
Article
Biology
Aliya Mari Adefuin, Sander Lindeman, Janine Kristin Reinert, Izumi Fukunaga
Summary: This study investigates how the olfactory system processes binary mixtures of odours in different brain states. It was found that mixture summation is more linear in awake mice performing an odour detection task, despite smaller and more variable responses. Decoding analyses indicated that the data from these mice was well discriminable, but decoding accuracy did not strictly correlate with the linearity of summation.
Article
Biochemistry & Molecular Biology
Julia E. Manoim, Andrew M. Davidson, Shirley Weiss, Toshihide Hige, Moshe Parnas
Summary: In this study, the authors investigated a neuromodulatory mechanism in fruit flies that is essential for achieving stimulus specificity in learning. They found that cholinergic Kenyon cells, which represent olfactory signals, have axo-axonic connections mediated by the muscarinic type-B receptor. These connections suppress both odor-evoked calcium responses and dopamine-evoked cAMP signals in neighboring cells, contributing to effective and accurate memory formation.
Article
Psychology, Biological
Anna Exner, Isabell Tapia Leon, Erik M. Mueller, Tim Klucken
Summary: This study aimed to systematically analyze the effects of aversive and appetitive conditioning on cardiac responses. Results showed conditioned responses in subjective ratings in both types of conditioning, while only aversive conditioning could be discriminated using skin conductance response. Cardiovascular responses indicated that deceleration for the CS+ was longer in both tasks, with aversive conditioning showing higher deceleration magnitude and shorter acceleration for the CS+ compared to the CS-.
Article
Computer Science, Artificial Intelligence
Yu Wang, Qilong Zhao, Mingyuan Ma, Jin Xu
Summary: This paper proposes a neural network-based perception prediction model that accurately predicts the relationship between the chemical structure and physicochemical properties of odor molecules. By imitating the lateral inhibition mechanism and attention mechanism of animal olfaction, the model achieves state-of-the-art results in olfactory perception prediction, which is of great significance for product design and quality assessment in the food, beverage, and fragrance industries.
APPLIED INTELLIGENCE
(2023)
Review
Behavioral Sciences
Dilara Gostolupce, Belinda P. P. Lay, Etienne J. P. Maes, Mihaela D. Iordanova
Summary: This article discusses associative learning and argues that the physical presence of stimuli is not necessary for this type of learning. It explains how associative relationships can form between events through the integration of information from different training phases. The article details the procedures and factors that influence learning in two similar designs (sensory preconditioning and second-order conditioning) and emphasizes the importance of studying this knowledge in understanding brain function.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biology
Sudeshna Das Chakraborty, Hetan Chang, Bill S. Hansson, Silke Sachse, Sonia Sen
Summary: This study investigated the transformation and representation of odor information in higher-order neurons of the lateral horn in Drosophila melanogaster. The researchers found that these neurons exhibited reproducible, stereotypic, and odor-specific response patterns. Importantly, the response amplitude of these neurons was positively correlated with innate odor preferences, suggesting that their activity is valence-specific. The study also revealed that the excitatory input to glutamatergic lateral horn neurons primarily came from uniglomerular projection neurons, while odor-specific inhibition was mediated by inhibitory multiglomerular neurons.
Article
Multidisciplinary Sciences
Seth R. Odell, David Clark, Nicholas Zito, Roshni Jain, Hui Gong, Kendall Warnock, Ricardo Carrion-Lopez, Coral Maixner, Lucia Prieto-Godino, Dennis Mathew
Summary: A study found that starving crawling insects exhibit reduced head wavings and straighter tracks when searching for food. By using Drosophila melanogaster larva as the research subject, it was revealed that the flexibility in insect navigation strategy might arise during early olfactory processing, with Keystone-LN, an inhibitory local neuron, playing a critical role in implementing head-sweep behavior. Insulin signaling is likely involved in mediating starvation-induced changes in the magnitude of head-sweeps and shaping the larva's odor-guided movement.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Haran Shani-Narkiss, David Beniaguev, Idan Segev, Adi Mizrahi
Summary: This study used time-lapse in vivo two-photon calcium imaging to describe changes in odor representation by mitral cells. The results showed that odor representations undergo significant re-shaping across different brain states but remain stable over time within the same state.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Review
Behavioral Sciences
Danielle I. Fournier, Han Yin Cheng, Siobhan Robinson, Travis P. Todd
Summary: This study focuses on the neuroanatomical basis of higher-order conditioning, specifically examining the role of the retrosplenial cortex (RSC) in sensory preconditioning and second-order conditioning. Research findings suggest that the RSC plays a role in sensory preconditioning by encoding neutral stimulus-stimulus associations.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Youcef Bouchekioua, Yutaka Kosaki, Shigeru Watanabe, Aaron P. Blaisdell
Summary: Spatial learning and memory are processes through which living organisms encode, compute, and retrieve information to perform goal-directed navigation, which has been systematically investigated since the early twentieth century. Animals learn to navigate space through trial and error, developing responses to stimuli that guide them to a goal place. Response learning and place learning are two strategies animals use to navigate, with the former involving a sequence of motor actions and the latter involving learning locations with respect to an allocentric framework.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ping Zhu, Shuge Liu, Yulan Tian, Yating Chen, Wei Chen, Ping Wang, Liping Du, Chunsheng Wu
Summary: This study investigated the effects of odor stimulation on olfactory gamma oscillations and high-frequency oscillations in awake and anesthetized rats. The results showed that odor stimulation modulated LFP oscillations differently in animals of both states, and theta-HGO and theta-HFO coupling were modified only in awake animals.
FRONTIERS IN CHEMISTRY
(2022)
Article
Zoology
Nina Mohebbi, Andrew Schulz, Thomas L. Spencer, Kelsie Pos, Andrew Mandel, Jerome Casas, David L. Hu
Summary: Body size affects the surface area and sensory neuron density of olfactory organs. Moths have a higher proportion of olfactory surface area compared to mammals. The density of olfactory neurons seems to be near the limit in both insects and mammals.
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2022)
Article
Biology
Nicolas Pirez, Martin Klappenbach, Fernando F. Locatelli
Summary: Insects rely on their sense of smell to perceive informative odors for reproduction, but these odors may be mixed with environmental odors that can disrupt their perception. The first two layers of the olfactory system play a critical role in optimizing the representation of the odors of interest, and experiencedependent changes affect these two layers.
CURRENT OPINION IN INSECT SCIENCE
(2023)
Article
Biochemical Research Methods
Kuo-Hua Huang, Peter Rupprecht, Thomas Frank, Koichi Kawakami, Tewis Bouwmeester, Rainer W. Friedrich
Article
Neurosciences
Adrian A. Wanner, Rainer W. Friedrich
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Yuto Uemura, Kagayaki Kato, Koichi Kawakami, Yukiko Kimura, Yoichi Oda, Shin-ichi Higashijima
JOURNAL OF NEUROSCIENCE
(2020)
Article
Developmental Biology
Takamasa Mizoguchi, Michi Fukada, Miku Iihama, Xuehui Song, Shun Fukagawa, Shuhei Kuwabara, Shuhei Omaru, Shin-ichi Higashijima, Motoyuki Itoh
Review
Neurosciences
Rainer W. Friedrich, Adrian A. Wanner
Summary: Dynamic connectomics in zebrafish can provide insights into the circuit mechanisms underlying higher-order neuronal computations by combining reconstructions of wiring diagrams with measurements of neuronal population activity and behavior.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021
(2021)
Article
Neurosciences
Peter Rupprecht, Stefano Carta, Adrian Hoffmann, Mayumi Echizen, Antonin Blot, Alex C. Kwan, Yang Dan, Sonja B. Hofer, Kazuo Kitamura, Fritjof Helmchen, Rainer W. Friedrich
Summary: Researchers developed an algorithm for spike inference (CASCADE) based on supervised deep networks, utilizing a large ground truth database to infer absolute spike rates and outperforming existing model-based algorithms. CASCADE optimizes performance for unseen data by resampling ground truth data, matching the respective sampling rate and noise level, without the need for user adjustment of any parameters.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Urs L. Bohm, Yukiko Kimura, Takashi Kawashima, Misha B. Ahrens, Shin-ichi Higashijima, Florian Engert, Adam E. Cohen
Summary: The activity of ventral V3 neurons in zebrafish is positively correlated with swimming strength and bout length. Activation of these neurons leads to stronger and longer swimming, but does not affect tail beat frequency. Genetic ablation experiments further confirm the critical role of V3 neurons in locomotor adaptation.
Article
Biology
Chie Satou, Rachael L. Neve, Hassana K. Oyibo, Pawel Zmarz, Kuo-Hua Huang, Estelle Arn Bouldoires, Takuma Mori, Shin-ichi Higashijima, Georg B. Keller, Rainer W. Friedrich
Summary: This study developed methods for gene transfer and retrograde tracing in zebrafish, as well as efficient transneuronal tracing. Herpes simplex viruses and modified rabies viruses were used to visualize and manipulate neurons in zebrafish.
Article
Multidisciplinary Sciences
Masashi Tanimoto, Ikuko Watakabe, Shin-Ichi Higashijima
Summary: Spatio-temporal information about head orientation and movement is crucial for balance and motion perception. In this study, we used in vivo Ca2+ imaging to investigate the response patterns of hair cells and ganglion neurons in larval zebrafish to static tilt and vibration. Our results suggest that different types of hair cells in the otolith organs respond selectively to head vibration and static tilt, while maintaining a spatially ordered direction preference that is preserved in ganglion neurons. This demonstrates the presence of topographically organized selectivity for the direction and dynamics of head orientation/movement in the vestibular periphery.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Tanmoy Sarkar, Katharina Lieberth, Aristea Pavlou, Thomas Frank, Volker Mailaender, Iain McCulloch, Paul W. M. Blom, Fabrizio Torriccelli, Paschalis Gkoupidenis
Summary: This study presents an organic artificial neuron based on a compact nonlinear electrochemical element. The artificial neuron is capable of operating in a liquid and can respond to the concentration of biological species in its surroundings. The system offers in situ operation and spiking behavior in biologically relevant environments.
NATURE ELECTRONICS
(2022)
Correction
Engineering, Electrical & Electronic
Tanmoy Sarkar, Katharina Lieberth, Aristea Pavlou, Thomas Frank, Volker Mailaender, Iain McCulloch, Paul W. M. Blom, Fabrizio Torricelli, Paschalis Gkoupidenis
NATURE ELECTRONICS
(2022)
Article
Multidisciplinary Sciences
Takumi Sugioka, Masashi Tanimoto, Shin-ichi Higashijima
Summary: This study demonstrates that larval zebrafish can finely control their posture through a body bend reflex. The authors also identify the neural circuits and muscles involved in this reflex.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Irene Pallucchi, Maria Bertuzzi, David Madrid, Pierre Fontanel, Shin-ichi Higashijima, Abdeljabbar El Manira
Summary: This study links the molecular diversity of motoneurons and V2a interneurons with the modular circuit organization that controls locomotor speed in adult zebrafish. It reveals functional segregation and shared molecular signatures among different subtypes of neurons, providing important insights into the molecular mechanisms underlying motor circuit modularity.
NATURE NEUROSCIENCE
(2023)