Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency

Abnormal mTOR Activation in Autism

(2018) Kellen D. Winden et al.   Annual Review of Neuroscience

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

(2018) Ping Jun Zhu et al.   NATURE NEUROSCIENCE

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

(2017) Carlo Rinaldi et al.   Nature Reviews Neurology

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

(2017) Shira Knafo et al.   TRENDS IN NEUROSCIENCES

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

(2016) Shelly A. Buffington et al.   CELL

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

(2016) Wei Huang et al.   eLife

mTOR Inhibition in Epilepsy: Rationale and Clinical Perspectives

(2015) Adam P. Ostendorf et al.   CNS DRUGS

mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia

(2015) Lena H. Nguyen et al.   EPILEPSIA

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder

(2015) A K Tilot et al.   MOLECULAR PSYCHIATRY

Single-Gene Determinants of Epilepsy Comorbidity

(2015) Jeffrey L. Noebels   Cold Spring Harbor Perspectives in Medicine

Megalencephaly and hemimegalencephaly: Breakthroughs in molecular etiology

(2014) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Diverse Genetic Landscape of Neurodevelopmental Disorders

(2014) Wen F. Hu et al.   Annual Review of Genomics and Human Genetics

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly

(2013) Judith A Hobert et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

PTEN signaling in autism spectrum disorders

(2012) Jing Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly

(2010) Kim L. McBride et al.   Autism Research

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids

(2009) Yewei Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

(2009) M. C. Ljungberg et al.   Disease Models & Mechanisms

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY