期刊
NATURE MEDICINE
卷 25, 期 10, 页码 1500-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41591-019-0600-6
关键词
-
资金
- Hebrew University of Jerusalem
- Leona M. and Harry B. Helmsley Charitable Trust
- Adelis Foundation
- Pearl Welinsky Merlo Scientific Progress Research Fund
- Lawrence and Sandra Post Family Foundation
- Daniel Morris Trust
- Park Avenue Charitable Fund
- Hanna and Dr. Ludwik Wallach Cancer Research Fund
- Howard and Nancy Marks Charitable Fund
- estate of Malka Moskowitz
- estate of Myron H. Ackerman
- estate of Bernard Bishin
- European Research Council
- Israel Science Foundation
- Israel Ministry of Health
- Helmholtz Foundation
- Else Kroener Fresenius Foundation
- Garvan Institute
- European Crohn's and Colitis Organization
- Deutsch-Israelische Projektkooperation
- Wellcome Trust
- Hadassah Medical Center
- Israel Ministry of Science and Technology
We report the results of a first exploratory study testing the use of vaginal microbiome transplantation (VMT) from healthy donors as a therapeutic alternative for patients suffering from symptomatic, intractable and recurrent bacterial vaginosis (ClinicalTrials. gov NCT02236429). In our case series, five patients were treated, and in four of them VMT was associated with full long-term remission until the end of follow-up at 5-21 months after VMT, defined as marked improvement of symptoms, Amsel criteria, microscopic vaginal fluid appearance and reconstitution of a Lactobacillus-dominated vaginal microbiome. One patient presented with incomplete remission in clinical and laboratory features. No adverse effects were observed in any of the five women. Notably, remission in three patients necessitated repeated VMT, including a donor change in one patient, to elicit a long-standing clinical response. The therapeutic efficacy of VMT in women with intractable and recurrent bacterial vaginosis should be further determined in randomized, placebo-controlled clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据