期刊
NATURE IMMUNOLOGY
卷 20, 期 11, 页码 1435-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0493-z
关键词
-
类别
资金
- NIH [U19 AI104209, R01 AR067145, R01 AI32494, NS069375]
- 'Incentive Grant for Scientific Research' of the F.R.S.-FNRS [F.4508.18]
- FRFS-WELBIO [CR-2017s-04]
- Acteria Foundation
- ERC [IM-ID 801823]
- Austrian Science Fund [P31113-B30]
- European Commission [H2020-MSCA-IF-2014 656086]
- INSERM ATIPAvenir program
- United States-Israel Binational Science Foundation [2013263]
- Sean N. Parker Center for Allergy and Asthma Research, Stanford University
- Societe Francaise de Dermatologie
- Societe Francaise d'Allergologie
- Marie Sklodowska-Curie Individual Fellowship [749629]
- European Research Council (ERC-2018-STG) [802041]
- INSERM ATIP-Avenir program
- Marie Curie Actions (MSCA) [749629] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [802041] Funding Source: European Research Council (ERC)
- Austrian Science Fund (FWF) [P31113] Funding Source: Austrian Science Fund (FWF)
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. Intravital imaging and genetic approaches indicated that HDM-activated nociceptors drive the development of allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of substance P and the activation of the cationic molecule receptor MRGPRB2 on mast cells. These data indicate that, after exposure to HDM allergens, activation of TRPV1(+)Tac1(+) nociceptor-MRGPRB2(+) mast cell sensory clusters represents a key early event in the development of allergic skin reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据