Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

(2018) Eloy Cuadrado et al.   IMMUNITY

Hexokinase II may be dispensable for CD4 T cell responses against a virus infection

(2018) Siva Karthik Varanasi et al.   PLoS One

Single cell analysis of kynurenine and System L amino acid transport in T cells

(2018) Linda V. Sinclair et al.   Nature Communications

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling

(2018) Sara Ricciardi et al.   Cell Metabolism

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function

(2017) Fanny Duguet et al.   MOLECULAR & CELLULAR PROTEOMICS

The Encyclopedia of Proteome Dynamics: a big data ecosystem for (prote)omics

(2017) Alejandro Brenes et al.   NUCLEIC ACIDS RESEARCH

NFATc1 controls the cytotoxicity of CD8+ T cells

(2017) Stefan Klein-Hessling et al.   Nature Communications

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

(2016) Jialong Yang et al.   eLife

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The role of mTOR in memory CD8+ T-cell differentiation

(2010) Koichi Araki et al.   IMMUNOLOGICAL REVIEWS

Structural basis for translational inhibition by the tumour suppressor Pdcd4

(2009) Portia G Loh et al.   EMBO JOURNAL

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

(2008) C. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA