Article
Nanoscience & Nanotechnology
Manman Gong, Fei Li, Lei Wang, Qiulei Xu, Zhenghui Wu, Huaibin Shen, Lin Song Li, Zuliang Du
Summary: In this study, highly monodisperse PbS quantum dots with tailored facet growth were synthesized using the continuous precursor injection method. A multilayered organic-inorganic hybrid architecture was used to fabricate infrared PbS QLEDs, which exhibited high radiance. This work provides an effective approach for preparing high-quality PbS quantum dots and has the potential to boost the commercial applications of PbS QLEDs.
Article
Chemistry, Physical
Alexey A. A. Pakhomov, Anna V. V. Efremova, Yuriy N. N. Kononevich, Dmitriy S. S. Ionov, Margarita A. A. Maksimova, Alexander D. D. Volodin, Alexander A. A. Korlyukov, Nikita O. O. Dubinets, Vladimir I. I. Martynov, Anatoly A. A. Ivanov, Aziz M. M. Muzafarov
Summary: Fluorescent dyes that emit/excite in the second near-infrared (NIR-II, 1000-1350 nm) region are gaining attention in bioimaging and diagnostics applications. Dyes with high two-photon absorption cross-section (TPA), like BODIPY derivatives, are of particular interest due to their ability to penetrate deeper into biological tissues and provide better imaging contrast with reduced phototoxicity and photobleaching. This study reports the synthesis and properties of new monomeric and dimeric di-styryl-BODIPY dyes, which exhibit absorption maxima near 625 nm and emit in the range of 600-800 nm (NIR-I, 650-950 nm). The dyes were excited using a femtosecond Cr:Forsterite laser with a wavelength of 1250 nm (NIR-II) and a cooperative effect of TPA was observed for the dimeric di-styryl-BODIPY dyes. These results are significant for their potential applications in bioimaging and photodynamic therapy.
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yunxiang Di, Kun Ba, Yan Chen, Xudong Wang, Mingqing Zhang, Xinning Huang, Yi Long, Mengdi Liu, Shukui Zhang, Weiyi Tang, Zhangcheng Huang, Tie Lin, Hong Shen, Xiangjian Meng, Meikang Han, Qi Liu, Jianlu Wang
Summary: A two-dimensional titanium carbide (Ti3C2Tx) MXene film is introduced as an effective transparent conducting electrode in lead sulfide quantum dot photodiodes. Exhibiting exceptional near-infrared transmittance control, interface engineering enhances performance, yielding high detectivity, extensive dynamic response, and notable bandwidth, thereby advancing infrared photodiode technology.
Article
Engineering, Electrical & Electronic
Ruiyang Yan, Chan Yang, Zhongmin Guo, Yihan Hua, Pei Li, Xinru Zhang, Shuanglong Feng
Summary: A hybrid structure of nanoparticle Bi/PbS submicron plate photodetector was fabricated by electrochemical atomic layer epitaxy, which exhibited excellent properties and improved response speed compared to previous studies. The high-quality single crystal PbS rods and perfect coating of Bi were confirmed by SEM, AFM, and TEM analysis. This work opens up new opportunities for the development of high-sensitivity photodetectors based on metal nanoparticles and semiconductors for industrial and commercial applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Multidisciplinary
Yuxin Bao, Xi Wu, Bingyang Bo, Jinglei Qin, Yafei Zhang, Xiaojia Wu, Xiang Li, Yiquan Wang, Hongshang Peng
Summary: In this study, a reprecipitation-encapsulation method was used to co-load near infrared II (NIR-II) fluorescent Ag2S quantum dots (QDs) and photosensitizer zinc phthalocyanine (ZnPc) into single nanoparticles (NPs). The resulting Ag2S/ZnPc NPs, coated by a poly-L-lysine (PLL) layer, showed good biocompatibility and exhibited strong NIR-II fluorescence. They demonstrated efficient phototherapeutic efficacy on HeLa cells and achieved a deep tissue penetration depth of 1.4 mm. These findings indicate that the facilely prepared Ag2S/ZnPc NPs hold great promise for NIR-II fluorescence imaging-guided in vivo PDT.
Review
Chemistry, Multidisciplinary
Jing Mu, Ming Xiao, Yu Shi, Xuewen Geng, Hui Li, Yuxin Yin, Xiaoyuan Chen
Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Chen-hao Xu, Sheng-Hui Luo, Yang Wang, Xiao-Feng Shi, Can Fu, Jiang Wang, Chun-Yan Wu, Lin-Bao Luo
Summary: This study presents a solution method for a dual-band photodetector (PD) based on silicon nanowires /PbS nanocrystalline film n-n heterojunction. The device exhibits bias-selectable spectral response in the near-infrared (NIR) and short-wave infrared (SWIR) bands by adjusting the polarity of the bias voltage. It achieves high responsivities and detectivity in the NIR region, comparable to or even better than some commercial PDs, due to improved optical absorption and charge separation and collection efficiency through the heterojunction geometry. The study demonstrates the potential of detecting two distinct IR regions with the same pixel for future optoelectronic systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Hongping Zhao, Man Zhao, Dayong Jiang
Summary: The study proposes a broadband photodetector with high response, high sensitivity, and controllable band by integrating quantum dots and highly conductive materials. The PD composed of ZnO film/PbS quantum dots heterostructure shows excellent photoresponse performance in the UV-Vis-NIR range, with the peak responsivity increased by 550%, accompanied by significant red shift, faster response, and recovery speed. By using RF magnetron sputtering to prepare ultra-thin ZnO film, the impact of PbS quantum dots on the photoelectric properties of ZnO film is comprehensively and systematically discussed.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2024)
Review
Chemistry, Multidisciplinary
Paige A. Shaw, Ewan Forsyth, Fizza Haseeb, Shufan Yang, Mark Bradley, Maxime Klausen
Summary: This review provides an update on available 2P instrumentation and 2P luminescent materials for optical imaging in the NIR-II window, showcasing how two-photon absorption can provide convenient access to the second biological transparency window and increase resolution capabilities.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chao Zhao, Fangyuan Zhou, Kai Lu, Shikui Yang, Baojin Tan, Wanlu Sun, Lina Shangguan, Hai-Yan Wang, Yi Liu
Summary: The study designed and synthesized a novel near-infrared fluorescent probe to detect AChE activity, showing high specificity and sensitivity, as well as good biocompatibility both in vitro and in vivo. The probe provides a rapid and visual strategy for monitoring AChE activity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Xiao Li, Ning He, Xiaojing Li, Xu Wang, Lei Zhan, Jialin Song, Wei-En Yuan, Yuanming Ouyang
Summary: A conductive GDY nanomaterial-loaded PCL scaffold was prepared and evaluated for its biocompatibility and effectiveness in peripheral nerve regeneration. The GDY/PCL scaffold significantly improved the proliferation, adhesion, and glial expression of Schwann cells, as well as promoted myelination and axonal growth in a rat sciatic nerve defect model. Additionally, upregulation of vascular factor expression suggested a potential role in angiogenesis for nerve repair.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Hai Xu, Song-Ling Wu, Nai-Jie Lin, Yuan Lu, Jian Xiao, Ya-Wen Wang, Yu Peng
Summary: The near-infrared fluorescent probe SWJT-1, based on C=N isomerization, shows excellent response to ClO with low detection limit, high selectivity, and rapid detection. The sensing mechanism of SWJT-1 for ClO has been confirmed through various analytical techniques, and it has been successfully applied in bioimaging for the detection of ClO in vitro and vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Article
Engineering, Biomedical
Bulin Du, Ruiqi Liu, Chunrong Qu, Kun Qian, Yongkuan Suo, Fengxia Wu, Hongda Chen, Xuena Li, Yaming Li, Hongguang Liu, Zhen Cheng
Summary: Phototheranostics, which integrates diagnostic fluorescence imaging and photo-driven therapy using fluorophores, shows great potential for cancer precision medicine. In this study, human serum albumin nanoparticles were used to improve the water solubility and circulation time of the NIR-II dye IR1061, enabling it to be used for noninvasive imaging and photothermal therapy. The novel albumin-based NIR II dye nanoparticle, IR1061@HSA, has high biocompatibility and promising clinical translation prospects.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Zhu Zhu, Zhaoqi Yuan, Linxiumei Guo, Yeltai Nurzat, Heng Xu, Yixin Zhang
Summary: Delayed neovascularization and unstable adipose formation are major challenges in adipose tissue engineering. This study introduces two modifications, including the addition of CCL2 and the use of a vascularized fibrous capsule, to optimize the adipose tissue engineering system. These modifications enhance adipogenesis, angiogenesis, construct stability, tissue remodeling, and upregulate leptin expression. The optimized system provides a strategy for reconstructing soft tissue defects with improved adipogenesis and angiogenesis.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Heng Xu, Zhu Zhu, Jian Hu, Jiawei Sun, Yan Wo, Xianshu Wang, Hongzhi Zou, Bin Li, Yixin Zhang
Summary: This study found that downregulation of cytotoxic CD8(+) T cells is a specific signature of keloids. Additionally, the upregulation of the NKG2A/CD94 complex and high levels of soluble human leukocyte antigen-E (sHLA-E) were associated with keloid formation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Zhu Zhu, Linxiumei Guo, Nurzat Yeltai, Heng Xu, Yixin Zhang
Summary: This study demonstrates that CCL2 directly promotes adipogenesis of hADSCs and angiogenesis of HUVECs in vitro, with 50 ng/ml CCL2 showing the strongest adipogenic and angiogenic potential.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Yeletai Nurzati, Zhu Zhu, Heng Xu, Yixin Zhang
Summary: This study identified three novel miRNAs (miR-30b-5p, miR-212-3p, miR-149-5p) and five target mRNAs (SIX1, CCNA2, CCNB1, FOXM1, RUNX2) as potential biomarkers for keloid patients. Functional analyses of these miRNA-mRNA pathways provided insights into the underlying pathogenesis of keloid and could be used for keloid diagnosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov
Summary: In this study, an AI-driven target discovery platform called PandaOmics was used to analyze the expression profiles of CNS samples and direct iPSC-derived motor neurons from public datasets and Answer ALS. The study identified 17 high-confidence and 11 novel therapeutic targets, and verified their therapeutic effects in a fruit fly model. The research provides new insights into ALS pathophysiology and demonstrates the ability of AI to speed up the target discovery process.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Le Yu, Evelyne Bischof, Hui-Hong Lu
Summary: Ciprofol, a novel intravenous general anesthetic, has been proven safe and effective for anesthesia in cardiac surgery with cardiopulmonary bypass. This case study demonstrates its advantages of fast onset, stable circulation, and few adverse reactions, with the patient recovering well after surgery.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Multidisciplinary Sciences
Naomi I. Maria, Rosaria Valentina Rapicavoli, Salvatore Alaimo, Evelyne Bischof, Alessia Stasuzzo, Jantine A. C. Broek, Alfredo Pulvirenti, Bud Mishra, Ashley J. Duits, Alfredo Ferro, RxCOVEA Framework
Summary: The current pandemic has created an urgent need for identifying potential drugs for COVID-19. However, our understanding of the host-immune response to SARS-CoV-2 is limited, and there are only a few approved drugs available. To address this, a systems biology tool called PHENotype SIMulator has been introduced. This tool uses transcriptomic and proteomic databases to simulate SARS-CoV-2 infection in host cells, allowing for the identification of viral effects on host-immune response with high sensitivity and specificity (>96%).
Review
Cell Biology
Fedor Galkin, Olga Kovalchuk, Diana Koldasbayeva, Alex Zhavoronkov, Evelyne Bischof
Summary: Epigenetic aging clocks are valuable tools for predicting age-related health conditions and studying the mechanisms of aging. This review examines the effects of modifiable lifestyle factors on DNA methylation levels and discusses their contribution to biological aging. It also provides insights for individuals interested in adopting an evidence-based longevity lifestyle.
AGEING RESEARCH REVIEWS
(2023)
Article
Geriatrics & Gerontology
Evelyne Bischof
Summary: The COVID-19 pandemic has resulted in immense pressure on global healthcare systems, leading to a rush in the development and approval of medications. China is focusing on the health of the elderly population and implementing herd immunity strategies to minimize overall deaths and morbidity. This paper reviews the safety and efficacy of available COVID-19 medications in China, with a specific focus on 3CL protease inhibitors and the aging population.
Letter
Geriatrics & Gerontology
Ilia Stambler, Aleksey Alekseev, Yuri Matveyev, Daria Khaltourina
LANCET HEALTHY LONGEVITY
(2022)
Meeting Abstract
Immunology
Naomi I. Maria, Rosaria Valentina Rapicavoli, Salvatore Alaimo, Evelyne Bischof, Alfredo Pulvirenti, Bud Mishra, Ashley John Duits, Alfredo Ferro
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Kruse, E. Bischof, D. Raaz-Schrauder, S. Achenbach, B. Dietel, M. Tauchi, K. Urschel
Article
Endocrinology & Metabolism
Evelyne Bischof, Fabienne D. Schwab, Elena Laura Georgescu Margarint, Celine Montavon, Iris Zuenti, Anna Schollbach, Andreas Schoetzau, Anna Hirschmann, Julia Landin, Christian Meier, Kurzeder Christian, Marcus Vetter
Summary: This study evaluated the practice patterns of bone health guideline-based management in patients with ER + eBC, finding a high rate of adherence to SVGO recommendations but a still concerning fracture rate.
Article
Computer Science, Information Systems
Evelyne Bischof, Alex Botezatu, Sergey Jakimov, Ilya Suharenko, Alexey Ostrovski, Andrey Verbitsky, Yury Yanovich, Alex Zhavoronkov, Garri Zmudze
Summary: Decentralized autonomous organizations (DAO) on the blockchain bring self-organization to a new level, but they lack a standardized solution for crisis management. A central authority is necessary for compliance reasons in certain domains, such as special-purpose financing, where the DAO governance model can be applied. This article presents a perspective on using modern technologies to organize special-purpose financing and considers longevity as a model example.
Article
Cell Biology
Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegue, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Bjoern Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G. J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen
Summary: Aging is the biggest risk factor for most chronic diseases, attracting attention from industry and investors. This year's ARDD meeting featured presentations from 75 speakers and included a longevity workshop to discuss aging mechanisms and potential modifications.