Prediction of the impact of coding missense and nonsense single nucleotide polymorphisms on HD5 and HBD1 antibacterial activity againstEscherichia coli

HD5 and HBD1 variants’ solvation potential energy correlates with their antibacterial activity against Escherichia coli

(2016) William F. Porto et al.   BIOPOLYMERS

Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5

(2015) Haritha R. Chileveru et al.   BIOCHEMISTRY

Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs

(2015) Basil Mathew et al.   PEPTIDES

Computational analyses and prediction of guanylin deleterious SNPs

(2015) William F. Porto et al.   PEPTIDES

PON-P2: Prediction Method for Fast and Reliable Identification of Harmful Variants

(2015) Abhishek Niroula et al.   PLoS One

SuSPect: Enhanced Prediction of Single Amino Acid Variant (SAV) Phenotype Using Network Features

(2014) Christopher M. Yates et al.   JOURNAL OF MOLECULAR BIOLOGY

In silico identification, structural characterization, and phylogenetic analysis of MdesDEF-2: a novel defensin from the Hessian fly, Mayetiola destructor

(2014) William F. Porto et al.   JOURNAL OF MOLECULAR MODELING

Shedding Some Light over the Floral Metabolism by Arum Lily (Zantedeschia aethiopica) Spathe De Novo Transcriptome Assembly

(2014) Elizabete de Souza Cândido et al.   PLoS One

Computational Analysis of Functional Single Nucleotide Polymorphisms Associated with the CYP11B2 Gene

(2014) Minyue Jia et al.   PLoS One

Deficient human  -defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

(2014) R. Diao et al.   Science Translational Medicine

Investigating the Impact of Asp181 Point Mutations on Interactions between PTP1B and Phosphotyrosine Substrate

(2014) Mengyuan Liu et al.   Scientific Reports

PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations

(2014) Jaroslav Bendl et al.   PLoS Computational Biology

Collective judgment predicts disease-associated single nucleotide variants

(2013) Emidio Capriotti et al.   BMC GENOMICS

WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation

(2013) Emidio Capriotti et al.   BMC GENOMICS

Computational Screening of Disease-Associated Mutations in OCA2 Gene

(2013) Balu Kamaraj et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Molecular Dynamic Simulation Reveals Damaging Impact of RAC1 F28L Mutation in the Switch I Region

(2013) Ambuj Kumar et al.   PLoS One

Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics Simulations

(2013) Aditya K. Padhi et al.   Scientific Reports

Exome sequencing and complex disease: practical aspects of rare variant association studies

(2012) R. Do et al.   HUMAN MOLECULAR GENETICS

Variation in human β-defensin genes: new insights from a multi-population study

(2012) R. K. Mehlotra et al.   International Journal of Immunogenetics

Functional Determinants of Human Enteric α-Defensin HD5

(2012) Mohsen Rajabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based mutant stability predictions on proteins of unknown structure

(2012) Giulia Gonnelli et al.   JOURNAL OF BIOTECHNOLOGY

Functional single-nucleotide polymorphisms in the DEFB1 gene are associated with systemic lupus erythematosus in Southern Brazilians

(2012) P Sandrin-Garcia et al.   LUPUS

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

In silico identification of novel hevein-like peptide precursors

(2012) William F. Porto et al.   PEPTIDES

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel

(2011) Abel González-Pérez et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The variant call format and VCFtools

(2011) P. Danecek et al.   BIOINFORMATICS

PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality

(2011) Yves Dehouck et al.   BMC BIOINFORMATICS

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Demographic history and rare allele sharing among human populations

(2011) S. Gravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How significant is a protein structure similarity with TM-score = 0.5?

(2010) Jinrui Xu et al.   BIOINFORMATICS

Human  -Defensin 3 Inhibits Cell Wall Biosynthesis in Staphylococci

(2010) V. Sass et al.   INFECTION AND IMMUNITY

Resonance Assignment and Three-Dimensional Structure Determination of a Human α-Defensin, HNP-1, by Solid-State NMR

(2010) Yuan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Defensin-Barbed Innate Immunity: Clinical Associations in the Pediatric Population

(2010) M. A. Underwood et al.   PEDIATRICS

In Silico screening for functional candidates amongst hypothetical proteins

(2009) Claus Desler et al.   BMC BIOINFORMATICS

Selective arginines are important for the antibacterial activity and host cell interaction of human α-defensin 5

(2009) Erik de Leeuw et al.   FEBS LETTERS

Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population

(2009) Eugene Kim et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

SNAP predicts effect of mutations on protein function

(2008) Yana Bromberg et al.   BIOINFORMATICS

Directional and balancing selection in human beta-defensins

(2008) Edward J Hollox et al.   BMC EVOLUTIONARY BIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CSαβ defensins

(2007) Shunyi Zhu   MOLECULAR IMMUNOLOGY