期刊
MULTIPLE SCLEROSIS JOURNAL
卷 26, 期 13, 页码 1647-1657出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458519885107
关键词
Multiple sclerosis; relapsing-remitting; quantitative MRI; NODDI; diffusion-weighted MRI; axonal loss
资金
- EPSRC [EP/I027084/1, EP/M020533/1, EP/N018702/1]
- ISRT [IMG006]
- UK MS Society [984]
- EPSRC [EP/I027084/1, EP/M020533/1, EP/N018702/1, EP/R006032/1] Funding Source: UKRI
Background: Multiple sclerosis (MS) affects both brain and spinal cord. However, studies of the neuraxis with advanced magnetic resonance imaging (MRI) are rare because of long acquisition times. We investigated neurodegeneration in MS brain and cervical spinal cord using neurite orientation dispersion and density imaging (NODDI). Objective: The aim of this study was to investigate possible alterations, and their clinical relevance, in neurite morphology along the brain and cervical spinal cord of relapsing-remitting MS (RRMS) patients. Methods: In total, 28 RRMS patients and 20 healthy controls (HCs) underwent brain and spinal cord NODDI at 3T. Physical and cognitive disability was assessed. Individual maps of orientation dispersion index (ODI) and neurite density index (NDI) in brain and spinal cord were obtained. We examined differences in NODDI measures between groups and the relationships between NODDI metrics and clinical scores using linear regression models adjusted for age, sex and brain tissue volumes or cord cross-sectional area (CSA). Results: Patients showed lower NDI in the brain normal-appearing white matter (WM) and spinal cord WM than HCs. In patients, a lower NDI in the spinal cord WM was associated with higher disability. Conclusion: Reduced neurite density occurs in the neuraxis but, especially when affecting the spinal cord, it may represent a mechanism of disability in MS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据