期刊
BIOPOLYMERS
卷 106, 期 6, 页码 884-888出版社
WILEY-BLACKWELL
DOI: 10.1002/bip.22929
关键词
conformational constraints; cyclic peptides; peptide design
资金
- U.S. Public Health Service, National Institutes of Health
Design of biologically active peptides is of critical importance for the development of potent, selective, nontoxic bioavailable drugs. A major approach that has been developed to accomplish this is the development of methods for the design and synthesis of a wide variety of cyclic peptides and peptidomimetics. In this short and general review, we outline themethods that have been developed for cyclization of peptides and how these have been used for peptide and peptidomimetic design using the melanotropin peptides and melanocortin receptors MC1R, MC3R, MC4R, and MC5R to illustrate aspects of this approach.
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