Article
Pharmacology & Pharmacy
Bhupendra Raj Giri, Jung Suk Kim, Jong Hyuck Park, Sung Giu Jin, Kyeong Soo Kim, Fakhar ud Din, Han Gon Choi, Dong Wuk Kim
Summary: Surface-attached solid dispersion (SASD) formulations were developed to enhance the solubility, bioavailability, and photostability of methotrexate (MTX). The spray-dried MTX-loaded SASD formulation improved the oral bioavailability of MTX without significant deterioration of its photochemical stability.
Review
Biotechnology & Applied Microbiology
Eliana B. Souto, Amanda Cano, Carlos Martins-Gomes, Tiago E. Coutinho, Aleksandra Zielinska, Amelia M. Silva
Summary: Microemulsions and nanoemulsions are pharmaceutical systems that can enhance drug permeation through the skin. They have differences in droplet size and stability. These systems have great potential for drug delivery and have been used in various applications.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Huijuan Zheng, Weilin Liu, Shuibing Yang
Summary: A nutraceutical carrier system was developed to increase the solubility of MCFA in aqueous foods, showing improved stability and sustained release of MCFAs in gastrointestinal fluid. The successful coating of nanoliposomes with CMCS resulted in negative surface charge, preventing particle aggregation and allowing safe retention of encapsulated MCFAs for up to 90 days at 4 degrees Celsius.
Review
Pharmacology & Pharmacy
Ahmad Salawi
Summary: Self-emulsifying drug delivery systems (SEDDS) are a proven method for increasing solubility and bioavailability of poorly soluble substances. This review provides an outline of SEDDS's advances and applications, focusing on the development of solid self-emulsifying delivery mechanism and dosage form. SEDDS has shown promising results in increasing oral bioavailability of lipophilic products and has the potential for new applications in medicine delivery.
Article
Chemistry, Multidisciplinary
Toshinari Ezawa, Yukiko Inagaki, Kinami Kashiwaba, Namiko Matsumoto, Hajime Moteki, Isamu Murata, Yutaka Inoue, Mitsutoshi Kimura, Masahiko Ogihara, Ikuo Kanamoto
Summary: This study evaluated the solubility of piperine in biorelevant media and its effects on intestinal contractions when presented in inclusion complexes with cyclodextrins. The results showed that inclusion complexes significantly suppressed intestinal contractility, with the PP/alpha CD complex exhibiting the highest solubility and efficacy in suppressing intestinal contractions.
Article
Biophysics
Nuntarat Boonlao, Uracha Rungsardthong Ruktanonchai, Anil Kumar Anal
Summary: Consumption of foods rich in antioxidants, vitamins, and minerals can boost the immune system to fight infections. Carotenoids, with multiple functions, face limitations in aqueous applications due to their lipophilic nature and instability, necessitating suitable delivery systems for enhanced solubility and bioavailability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Line Seguy, Florian Daressy, Sophia Lahlil, Sophie Corvaisier, Vincent Dumontet, Marc Litaudon, Cecile Apel, Fanny Roussi, Joelle Wiels, Aude Robert, Anne-Claire Groo, Aurelie Malzert-Freon
Summary: MCL-1, an overexpressed anti-apoptotic protein in cancer, can be effectively targeted by the natural compound NA1-115-7 isolated from Zygogynum pancheri. Lipid nanoemulsions (NA-NEs) were used to improve the solubility, stability, and efficacy of NA1-115-7. The encapsulated drug showed improved stability in acidic conditions and significantly restored apoptosis in cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Ali Mahmoudi, Prashant Kesharwani, Muhammed Majeed, Yong Teng, Amirhossein Sahebkar
Summary: Curcumin is a natural compound with promising therapeutic benefits, but it suffers from low solubility and bioavailability. Incorporating curcumin into gold nanoparticles can improve its properties and enhance its anticancer and antioxidant capacities. Additionally, the combination of nanogold and curcumin can be utilized in various therapeutic methods.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Food Science & Technology
Peng-Xiang Xu, Zhu-Qing Dai, Da-Jing Li, Chun-Quan Liu, Cai-E Wu, Jiang-Feng Song
Summary: This study developed lutein microparticles encapsulated with stevioside and beta-cyclodextrin via spray drying to enhance solubility and bioavailability. Optimization of encapsulation conditions resulted in improved in vitro bioaccessibility of lutein and spherical agglomerated structure of microparticles, showing promising potential for enhancing lutein bioavailability.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Chemistry, Multidisciplinary
Xiang-Yu Chen, Hui-Wen Yang, Shao-Ming Chi, Lu-Lu Yue, Qiong Ruan, Ze Lei, Hong-You Zhu, Yan Zhao
Summary: In this study, inclusion complexes between docetaxel and alkylenediamine-modified beta-cyclodextrins were prepared, which significantly increased the water solubility of docetaxel and exhibited better cytotoxicity against cancer cells compared to docetaxel alone.
Review
Food Science & Technology
Zhenfeng Xie, Xing Chen
Summary: This review article outlines the health benefits of resveratrol, introduces the current development of edible delivery systems of resveratrol, and prospects future research directions for safe-to-eat and environment-friendly encapsulation systems.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Anas Ahmad, Ravi Prakash, Mohd Shahnawaz Khan, Nojood Altwaijry, Muhammad Nadeem Asghar, Syed Shadab Raza, Rehan Khan
Summary: In this study, Naringenin nanoparticles were prepared using high-energy ball milling and their impact on antioxidant potential was investigated. The results indicated that the milled Naringenin nanoparticles showed significantly enhanced solubility and antioxidant activity compared to the crude Naringenin form.
Article
Chemistry, Multidisciplinary
Afzal Hussain, Syed Sarim Imam, Mohammad A. Altamimi, Mudassar Shahid, Osamah Abdulrahman Alnemer
Summary: This study aimed to develop green nanoemulsions using capryol-C90, lecithin, Tween 80, and N-methyl-2-pyrrolidone. The HSPiP software and experimental data were utilized to explore suitable excipients, and the nanoemulsions were evaluated for their in vitro characterization parameters. The results showed that the optimized nanoemulsions exhibited good hydrophobicity and stability under various stress conditions.
Article
Pharmacology & Pharmacy
Bhupendra Raj Giri, Hyun Seok Yang, Im-Sook Song, Han-Gon Choi, Jung Hyun Cho, Dong Wuk Kim
Summary: This study developed spray-dried amorphous inclusion complexes of methotrexate (MTX) with beta-cyclodextrin derivatives to enhance the drug's solubility, stability, and oral bioavailability in rats. The findings showed significant improvements in pharmacokinetic profiles with DM-beta-CD as the host, indicating a successful oral formulation technique for preventing drug degradation and enhancing pharmacological properties.
Review
Biochemistry & Molecular Biology
Nur Rafiqah Abdol Wahab, Meor Mohd Redzuan Meor Mohd Affandi, Sharida Fakurazi, Ekram Alias, Haniza Hassan
Summary: Astaxanthin, a compound with potential biological activity, has been shown to have antioxidant, anti-lipid peroxidation, and cardiovascular disease prevention properties. However, its poor oral bioavailability limits its clinical applications. Recent developments in nano-formulations have enhanced the bioavailability of astaxanthin, offering promising possibilities for future applications.
Article
Biochemistry & Molecular Biology
Aleksandra A. Ageeva, Alexander B. Doktorov, Olga Yu. Selyutina, Ilya M. Magin, Margarita G. Ilyina, Sophia S. Borisevich, Ruslan Yu. Rubtsov, Sergey L. Khursan, Alexander A. Stepanov, Sergey F. Vasilevsky, Nikolay E. Polyakov, Tatyana V. Leshina
Summary: This article discusses the spin effects in photoinduced electron transfer in diastereomers of donor-acceptor dyads and examines the influence of chirality on reactivity. The study reveals that the spin selectivity and the CIDNP coefficient are highly sensitive to changes in chiral centers, indicating the importance of optical configuration on the structure and reactivity of diastereomers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Olga Yu. Selyutina, Polina A. Kononova, Vladimir E. Koshman, Lidiya G. Fedenok, Nikolay E. Polyakov
Summary: Ascorbic acid can act as both an antioxidant and a pro-oxidant in redox reactions induced by transition metal ions. In a model system mimicking the cell membrane, ascorbic acid was found to accelerate lipid peroxidation induced by both iron and copper ions. It had no effect on the reactivity of the chelate complex with iron ions, but exhibited pro-oxidant activity in the reaction induced by the chelate complex with copper ions.
Article
Biochemistry & Molecular Biology
Aleksandra A. Ageeva, Alexander B. Doktorov, Nikolay E. Polyakov, Tatyana Leshina
Summary: This review provides an illustration of using model compounds to study the effects of substitution of L- for D-amino acid residues in amyloid peptides. The review presents examples of using diastereomers with L-/D-tryptophan in model process-photoinduced electron transfer for studying differences in reactivity and structure. Spin effects, fluorescence techniques, and molecular modeling have demonstrated a real difference in the structure and efficiency of electron transfer in diastereomers with L-/D-tryptophan residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Min Lu, Wei Wei, Wenhao Xu, Nikolay E. Polyakov, Alexandr Dushkin, Weike Su
Summary: This study prepared DNC/GA/PVP K30 solid dispersion using a mechanical ball milling method without organic solvents, aiming to enhance the aqueous solubility and anticoccidial activity of 4,4'-dinitrocarbanilide (DNC). The results showed that the solid dispersion significantly improved the solubility and dissolution rate of DNC, inhibited oocyst fecal output, and enhanced the therapeutic effect of coccidiosis. The solid dispersion also exhibited increased oral bioavailability and liver concentration, indicating potential applications in the treatment of coccidiosis and further research on schistosomiasis.
Article
Biochemistry & Molecular Biology
Anna Mastova, Olga Yu Selyutina, Nikolay E. Polyakov
Summary: The mechanisms of stereoselectivity in the interaction of chiral drugs with enzymes and cell receptors are important for disease treatment and understanding the therapeutic effects and side effects of drugs.
Article
Biochemistry & Molecular Biology
Anna Mastova, Olga Yu Selyutina, Veronika Evseenko, Nikolay E. Polyakov
Summary: Research has shown that ketoprofen produces free radicals under light conditions, penetrating lipid bilayers and causing photolysis, with different pathways in different mediums. Additionally, ketoprofen's reaction with the electron donor tryptophan is more efficient than with lipid molecules.
Article
Biochemistry & Molecular Biology
Olga Yu. Selyutina, Anna V. Mastova, Nikolay E. Polyakov
Summary: Q1 can form chelate complexes with transition metal ions, enhancing its penetration ability in the cell membrane, and it can affect lipid mobility in the bilayer, which is important for understanding Q1's biological activity.
Review
Biochemistry & Molecular Biology
Wenjing Su, Wenhao Xu, Enshuo Liu, Weike Su, Nikolay E. Polyakov
Summary: Natural bioactive compounds such as carotenoids have been used for the treatment of Alzheimer's disease. However, their low solubility, poor stability, and low bioavailability hinder their effectiveness. Nano-drug delivery systems have been developed to enhance the solubility, stability, permeability, and bioavailability of carotenoids for the treatment of Alzheimer's disease. This review summarizes the recent developments in carotenoid nano-drug delivery systems, including polymer, lipid, inorganic, and hybrid systems, and their therapeutic effects on Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilya M. M. Magin, Ivan A. A. Pushkin, Aleksandra A. A. Ageeva, Sofia O. O. Martianova, Nikolay E. E. Polyakov, Alexander B. B. Doktorov, Tatyana V. V. Leshina
Summary: Non-covalent interactions are crucial in the function of biomolecules, and researchers are interested in the role of chiral configuration in associations. A recent study showed that chemically induced dynamic nuclear polarization (CIDNP) formed in photoinduced electron transfer (PET) in chiral donor-acceptor dyads is sensitive to non-covalent interactions. This study further analyzed the factors determining association using different optical configurations of diastereomers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nikolay E. Polyakov, A. Ligia Focsan, Yunlong Gao, Lowell D. Kispert
Summary: Carotenoids are diverse compounds with potential health benefits, and studying their physicochemical properties using EPR and DFT can provide insights into their chemical structure and interaction with other molecules. Rare carotenoids, such as sioxanthin and siphonaxanthin, can form multiple bonds in host molecules, improving their stability, antioxidant activity, and control of photo-oxidation. Nanosized supramolecular systems for carotenoid delivery can also enhance the stability and biological activity of rare carotenoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra A. Ageeva, Roman S. Lukyanov, Sofia O. Martyanova, Ilya M. Magin, Alexander I. Kruppa, Nikolay E. Polyakov, Victor F. Plyusnin, Alexander B. Doktorov, Tatyana V. Leshina
Summary: This study investigates the photoinduced intramolecular and intermolecular processes of short peptides Lysine-Tryptophan-Lysine (Lys-{L/D-Trp}-Lys) and Lys-Trp-Lys with an acetate counter-ion. The reactivity of L- and D-amino acids has been a focus in various specialties, particularly in relation to Alzheimer's disease. Through NMR, CIDNP, and fluorescence techniques, the influence of tryptophan optical configuration on fluorescence quantum yields, quenching rates, and photocleavage products was observed. Results show that the L-isomer has a higher efficiency in quenching the Trp excited state compared to the D-analog, indicating an electron transfer mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga Yu. Selyutina, Viktor A. Timoshnikov, Nikolay E. Polyakov, George J. Kontoghiorghes
Summary: Omadine and its metal complexes have various medical applications and exhibit bactericidal, fungicidal, anticancer, and photochemical activity. The redox activity of omadine complexes with iron, copper, and zinc on lipid peroxidation under light and dark conditions has been studied. The omadine-zinc complex can induce the oxidation of linoleic acid under light irradiation, while the complexes with iron and copper are photochemically stable. These findings suggest that omadine can act as an antioxidant during processes involving reactive oxygen species generated by transition metals, but the omadine-zinc complex, widely used in shampoos and ointments, can cause oxidative cell membrane damage when exposed to light, potentially affecting health.
Article
Biochemistry & Molecular Biology
Polina A. Kononova, Olga Yu. Selyutina, Nikolay E. Polyakov
Summary: The interaction between the transmembrane domain of SARS-CoV-2 E-protein and glycyrrhizic acid in a model lipid bilayer has been studied using NMR techniques. Glycyrrhizic acid, the active component of licorice root, shows antiviral activity against enveloped viruses including coronavirus. The study suggests that glycyrrhizic acid can affect the fusion stage between viral particles and host cells by incorporating into the membrane. NMR spectroscopy revealed that glycyrrhizic acid penetrates into the lipid bilayer in a protonated state and localizes on the bilayer surface in a deprotonated state. The transmembrane domain of SARS-CoV-2 E-protein facilitates deeper penetration of glycyrrhizic acid into the hydrophobic region of bicelles, particularly at neutral pH, and it also influences the mobility of the transmembrane domain in the bilayer. These findings provide valuable insights into the molecular mechanism of glycyrrhizic acid's antiviral activity.
Article
Green & Sustainable Science & Technology
Wenjing Su, Wenhao Xu, Nikolay E. Polyakov, Alexandr V. Dushkin, Pei Qiao, Weike Su
Summary: This study developed an efficient zero-waste utilization method for shrimp shell waste through mechanochemistry. The method successfully converts shrimp shell waste into valuable substances without generating any waste. The research proposes a green economic reuse approach for crustacean waste, aligning with the concept of circular economy.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Medicinal
Olga Yu. Selyutina, Simon V. Babenko, Irina A. Slepneva, Nikolay E. Polyakov, George J. Kontoghiorghes
Summary: Schiff bases and similar molecules forming metal complexes can cause redox effects, which can be influenced by light. Anthraquinones such as doxorubicin and idarubicin are widely used antitumor agents that generate reactive oxygen species (ROS) stimulated by iron and copper ions as well as light. The study investigated the redox activity of the quinone-quinoline chelator Q1 in the presence of iron, copper, and zinc, and also examined the impact of light on these interactions. The findings highlight the role of transition metal ions and Q1 in cyclic redox chain reactions, suggesting the potential of copper- and iron-based chelating agents for anticancer therapy, as well as the use of light for enhancing ROS formation for designing target-specific anticancer drugs for photodynamic therapy.
