Article
Medicine, Research & Experimental
Teng Ma, Fan Qiu, Yanshan Gong, Hao Cao, Gonghua Dai, Daohan Sun, Dongling Zhu, Han Lei, Zhongmin Liu, Ling Gao
Summary: This study reveals the important role of long noncoding RNA RMST in cardiac fibrosis. RMST silencing inhibits cardiac fibroblast proliferation, fibroblast-to-myofibroblast transition, and extracellular matrix production. RMST acts as a competitive endogenous RNA of miR-24-3p, and targeting RMST shows therapeutic potential in alleviating fibrosis-related cardiac diseases.
Article
Biochemistry & Molecular Biology
Priyanka Priyanka, Madhur Sharma, Sanjeev Das, Sandeep Saxena
Summary: In this study, an upregulated lncRNA, HMS, was identified in lung adenocarcinoma patient database, which has a significant impact on cell proliferation and colony formation of cancer cells. It was found that HMS stabilizes HOXC10 mRNA to sustain the invasive phenotype of cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pediatrics
Lingling Zhou, Zhengke Zhi, Pingfa Chen, Chunxia Du, Binyu Wang, Xiang Fang, Weibing Tang, Hongxing Li
Summary: This study aimed to reveal the role of lncRNA rhabdomyosarcoma 2-associated transcript (RMST) in Hirschsprung's disease (HSCR). The results showed that RMST interacted with SOX2 to co-regulate the expression of miR-1251 and AHNAK, leading to the occurrence of HSCR. This finding provides potential targets for the diagnosis and treatment of HSCR.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Yongcan Xu, Xiang Yu, Jing Xu, Jun Lu, Hao Jiang, Neng Lou, Wei Lu, Jiewei Xu, Guochao Ye, Shunli Dong, Fengqi Nie
Summary: This study explored the expression level and functional role of lncRNA RP11-138J23.1 in gastric cancer (GC). The results showed that RP11-138J23.1 was upregulated in GC tissue and played a crucial role in promoting cell proliferation and metastasis. Mechanistically, RP11-138J23.1 exerted its oncogenic functions by binding to HuR protein and increasing stability of VAV3 mRNA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yan Wang, Changkun Lin, Yang Liu
Summary: It was found that OIP5-AS1 is highly expressed in colorectal cancer tissues and associated with poor prognosis. Silencing OIP5-AS1 inhibited malignant behaviors and growth of CC cells. miR-34b-5p inhibits proliferation and invasion of CC cells by targeting OIP5-AS1 and the PI3K/Akt pathway.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoshuai Ji, Zihao Liu, Jiajia Gao, Xin Bing, Dong He, Wenqing Liu, Yunda Wang, Yanbang Wei, Xianyong Yin, Fenglin Zhang, Min Han, Xiangdong Lu, Zixiao Wang, Qian Liu, Tao Xin
Summary: This study revealed the important role of long intergenic noncoding RNA in glioblastoma and its potential as a therapeutic target through modulating PTBP1-induced alternative splicing and m(6)A modification.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Chongsheng Xia, Yurui Sun, Yang Li, Junli Ma, Jing Shi
Summary: Acquisition of drug resistance is a major reason for treatment failure in cancer. Long non-coding RNA (CCAT1) plays an important role in oxaliplatin resistance in hepatocellular carcinoma. The study found that CCAT1 promotes HCC proliferation and resistance to oxaliplatin through the QKI-5/p38 MAPK signaling pathway. Targeting CCAT1 may be a promising strategy to reverse drug resistance in HCC treatment.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jiangning Zhao, Huanrong Lin, Kunsong Huang, Shen Li
Summary: In this study, it was found that cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) carrying SNHG3 can promote colorectal cancer (CRC) cell proliferation through the miR-34b-5p/HuR/HOXC6 axis. These findings reveal the important role of CAFs-EVs in CRC progression.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Yusheng Huang, Lei Xia, Xiangwu Tan, Jingyi Zhang, Weiwei Zeng, Benxu Tan, Xian Yu, Wei Fang, Zhenzhou Yang
Summary: In this study, the researchers investigated the role of lncRNA SNHG12 in immune escape of non-small cell lung cancer (NSCLC). They found that lncRNA SNHG12 binds to HuR, which in turn increases the levels of PD-L1 and USP8, promoting immune escape in NSCLC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yuhong Li, Hui Miao, Wei Wei, Jing Tian, Jian Chen
Summary: The study found that calycosin inhibits the growth and induces apoptosis of breast cancer cells by downregulating the expression of lncRNA HOTAIR. Additionally, calycosin reduces the expression levels of HuR and IGF2BP1. Therefore, lncRNA HOTAIR may play a carcinogenic role in breast cancer development and could be a potential therapeutic target for breast cancer treatment in the future.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Oncology
Shengtao Wang, Xinxin Zeng, Peng Gui, Shujuan Xu, Zhaoxu Li, Dongxu Chen
Summary: This study found that long non-coding RNA (lncRNA) EBLN3P promoted the proliferative, migrative, and invasive potentials of osteosarcoma (OS) cells by increasing the stability and protein level of Annexin A3 (ANXA3) mRNA through recruiting HuR. This discovery provides new potential therapeutic targets for clinical treatment of OS.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Heng-Jun Zhou, Li-Qing Wang, Ren-Ya Zhan, Xiu-Jue Zheng, Jie-Sheng Zheng
Summary: This study found that the expression of lncRNA MEG3 is decreased in ASCI, but its overexpression can inhibit the M1 polarization of microglia and neuroinflammation by regulating the NF-kappa B signaling pathway, thus promoting the recovery of spinal cord injury.
Article
Biochemistry & Molecular Biology
Zhe Wang, Jianfang Chen, Fengjun Sun, Xiang Zhao, Yan Dong, Songtao Yu, Jianjun Li, Houjie Liang
Summary: This study identified a clinically significant lncRNA, CRLM1, in colorectal cancer metastasis, which was found to promote metastasis and regulate gene expression. This discovery suggests that CRLM1 could serve as a potential biomarker and therapeutic target for colorectal liver metastases.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhi-Xuan Li, Zi-Qi Zheng, Pan-Yang Yang, Li Lin, Guan-Qun Zhou, Jia-Wei Lv, Lu-Lu Zhang, FoPing Chen, Ying-Qin Li, Chen-Fei Wu, Feng Li, Jun Ma, Na Liu, Ying Sun
Summary: In naso-pharyngeal carcinoma (NPC), Wilms' tumor 1-associating protein (WTAP) upregulation and its regulation of DIAPH1-AS1 m(6)A methylation play a critical role in tumor growth and metastasis.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Hongjian Zhou, Shengjie Li, Wanwan Pan, Shanshan Wu, Fei Ma, Ping Jin
Summary: In this study, a long noncoding RNA called lncRNA-CR33942 was found to play a positive regulatory role in the fruit fly's immune response to Gram-positive bacterial infection through interacting with Dorsal-related immunity factor/Dorsal. The lncRNA promotes the transcription of antimicrobial peptides, enhancing the Toll immune response in the fruit fly.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianghua Liu, Wan-Xin Peng, Yin-Yuan Mo, Dianzhong Luo
FRONTIERS IN BIOSCIENCE-LANDMARK
(2017)
Article
Biochemistry & Molecular Biology
Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong, Yin-Yuan Mo
Review
Biochemistry & Molecular Biology
W-X Peng, P. Koirala, Y-Y Mo
Article
Biochemistry & Molecular Biology
Wan-Xin Peng, Rong-Zhang He, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo
Article
Biochemistry & Molecular Biology
Xiaoge Hu, Wan-Xin Peng, Huaixiang Zhou, Jiahong Jiang, Xinchun Zhou, Dongsheng Huang, Yin-Yuan Mo, Liu Yang
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Huizhi Wang, Jie Li, Junbo He, Yawen Liu, Wen Feng, Hailang Zhou, Meng Zhou, Hong Wei, Ying Lu, Wanxin Peng, Fengyi Du, Aihua Gong, Min Xu
Article
Oncology
Rong-Zhang He, Jing Jiang, Xinglin Hu, Ming Lei, Jia Li, Weihao Luo, Lili Duan, Zheng Hu, Yin-Yuan Mo, Di-Xian Luo, Wan-Xin Peng
Summary: The study revealed that IGF2BP2 serves as a reader for m6A modified UCA1, and that METTL3 and WTAP positively regulate UCA1 expression. Mechanistically, IGF2BP2 increases the stability of m6A-modified UCA1. Additionally, IGF2BP2 is upregulated in CRC tissues compared with normal tissues, suggesting that m6A modification contributes to the upregulation of UCA1 in CRC tissues.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Xinchun Zhou, Jinghe Mao, Wanxin Peng, Zhenbang Chen, Hao Mei, Patrick Kyle, Yinyuan Mo, Timothy C. Allen
Summary: The study found that total lipids and neutral lipids in prostate cancer were significantly higher than in benign prostatic tissues in all populations and Caucasian American population, but not in African American population. Prostatic phospholipids were not statistically different between prostate cancer and benign prostatic tissues in all study populations. Cholesteryl ester was the only lipid class significantly higher in prostate cancer than in benign prostatic tissues in all study populations.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Cell Biology
Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo
Summary: This study identified Lnc-DC as a potential lncRNA involved in reducing tamoxifen-induced apoptosis and activating STAT3 to induce cytokine expression. Furthermore, the upregulation of Lnc-DC was associated with poor prognosis and could predict the response to tamoxifen in breast cancer patients.
CELL DEATH & DISEASE
(2021)
Editorial Material
Oncology
Wan-Xin Peng, Yin-Yuan Mo
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Qiu-Yu Li, Qian-Wen Xiong, Xuefeng Yao, Fei Liu, Xiaoxiao Tang, Haidong Fu, Tong Tong, Jianhua Mao, Wan-Xin Peng
Summary: Anemia is a common complication of chronic kidney disease, and current treatment options include erythropoiesis-stimulating agents (ESAs). However, the development of alternative therapies, such as roxadustat, has been of interest due to concerns about ESA resistance and safety issues.
BIOMOLECULES AND BIOMEDICINE
(2023)
Meeting Abstract
Oncology
Wan-Xin Peng, Liu Yang, Yin-Yuan Mo
Meeting Abstract
Gastroenterology & Hepatology
X. G. Hu, W. X. Peng, H. X. Zhou, J. H. Jiang, X. C. Zhou, D. S. Huang, Y. Y. Mo, L. Yang
Article
Cell Biology
Wan-xin Peng, Xiu Han, Chun-li Zhang, Lu Ge, Feng-yi Du, Jie Jin, Ai-hua Gong
CELL BIOLOGY AND TOXICOLOGY
(2017)