Article
Psychiatry
Erman Esnafoglu, Burak Subasi
Summary: Inflammatory mechanisms and vitamin D play important roles in the pathophysiology of Autism Spectrum Disorders (ASD). This study found that ASD patients had significantly higher levels of inflammatory markers and significantly lower levels of vitamin D. There was a negative correlation between vitamin D and inflammatory markers.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Developmental
Maria Carmen Gallardo-Carrasco, Jose Antonio Jimenez-Barbero, Maria del Mar Bravo-Pastor, David Martin-Castillo, Maria Sanchez-Munoz
Summary: The deficiency of vitamin and fatty acids in children diagnosed with autism may be related to the etiology and course of the disease. A review of 20 studies found lower levels of vitamin D in children with ASD compared to the control group. It is suggested that the nutritional status of patients diagnosed with ASD should be taken into account for potential improvement in the course of the disease.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Lauren M. Little, Karla Ausderau, Ashley Freuler, John Sideris, Grace T. Baranek
Summary: This study examined the relationship between children's sensory response patterns, child characteristics, and caregiver strategies in ASD and DD children. The findings showed that caregiver strategies were specifically associated with children's sensory response patterns, regardless of age or diagnosis. Qualitative analysis also revealed distinct caregiver strategies within different sensory patterns.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Mathilde Berard, Cecile Rattaz, Marianne Peries, Julie Loubersac, Kerim Munir, Amaria Baghdadli
Summary: The study found that containment and mitigation measures implemented during the COVID-19 pandemic had a significant impact on the behavior, communication skills, and sleep of children and youth with ASD. Factors such as subject age, ASD severity, family structure, daily living skills, and intervention continuity were identified as the most influential factors on behavior change.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Elisabetta Bolognesi, Franca Rosa Guerini, Stefano Sotgiu, Matteo Chiappedi, Alessandra Carta, Martina Maria Mensi, Cristina Agliardi, Milena Zanzottera, Mario Clerici
Summary: This study analyzed functional polymorphisms of vitamin D binding protein gene in ASD children and healthy controls, and found that the GC1f isoform was significantly more frequent in ASD children. The presence of GC1f isoform was associated with higher severity scores in clinical and functioning scales. These findings suggest that the GC1f isoform may serve as a marker of severity in ASD.
Review
Psychology, Developmental
Mark H. Johnson, Tony Charman, Andrew Pickles, Emily J. H. Jones
Summary: The AMEND framework aims to redefine the field of future research on neurodevelopmental disorders by proposing methods to separate early-stage disturbance markers from later developmental modifiers. Understanding how different perturbations and modifiers interact to produce phenotypic outcomes can advance both theoretical understanding and clinical approaches to developmental psychopathology in early childhood.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Psychology, Developmental
Darby Herkert, Connor Sullivan, YiQin Zhu, Geraldine Dawson
Summary: The American Academy of Pediatrics recommends screening for autism in children at 18 and 24 months. A study found that for the majority of children who screened positive for autism, there were prior concerns related to development or health. This suggests that screening can provide an opportunity for healthcare providers to address autism within the context of existing concerns.
Article
Psychiatry
Xiujie Qi, Ting Yang, Jie Chen, Ying Dai, Li Chen, Lijie Wu, Yan Hao, Ling Li, Jie Zhang, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Feiyong Jia, Tingyu Li
Summary: The study investigated the relationship between vitamin D levels and core symptoms and neurodevelopmental levels in children with ASD. The findings showed that children with ASD had lower vitamin D levels and that these levels were primarily associated with core symptoms. Further research is needed to determine the effectiveness of vitamin D supplementation in the treatment of ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Jet Muskens, Helen Klip, Janneke R. Zinkstok, Martine van Dongen-Boomsma, Wouter G. Staal
Summary: This study investigated the prevalence of vitamin D3 deficiency and its association with BMI in children with different psychiatric disorders. The results showed a high prevalence of vitamin D3 deficiency in these children, with an inverse relation between BMI and vitamin D3 levels.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Donatella Marazziti, Elisabetta Parra, Stefania Palermo, Filippo Maria Barberi, Beatrice Buccianelli, Sara Ricciardulli, Andrea Cappelli, Federico Mucci, Liliana Dell'Osso
Summary: Vitamin D plays an important role in regulating various processes in the human body and central nervous system, with its deficiency being associated with enhanced pro-inflammatory state and cognitive decline. It is believed to play a key role in the pathophysiology of various psychiatric disorders.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Monia Kittana, Asma Ahmadani, Lily Stojanovska, Amita Attlee
Summary: Children with autism spectrum disorder (ASD) have lower vitamin D levels and the deficiency is strongly correlated with ASD severity. Vitamin D supplementation can significantly reduce ASD severity, but the effect may vary between treatment and control groups. Variations in vitamin D dose protocols and concurrent interventions may contribute to the variability of results. The age of introducing vitamin D intervention may also affect the effectiveness of treatment. Further long-term, well-designed randomized controlled trials are needed to confirm the impact of vitamin D on severity in children with ASD.
Article
Psychiatry
Xuening Chang, Lingli Sun, Ruizhen Li
Summary: Children with autism spectrum disorders (ASD) often struggle with symbolic play. However, the effectiveness of the symbolic play test (SPT) in differentiating between ASD and other developmental disorders is inconsistent. This study aimed to evaluate the application of SPT in identifying ASD without global developmental delay (GDD) and developmental language disorder (DLD).
Article
Environmental Sciences
Mathilde Lize, Christine Monfort, Florence Rouget, Gwendolina Limon, Gael Durand, Helene Tillaut, Cecile Chevrier
Summary: This study found that prenatal exposure to certain organophosphate pesticides was associated with increased autistic traits in 11-year-old children. Specifically, maternal urine samples with detectable levels of chlorpyrifos or its metabolites were significantly associated with higher scores on autism spectrum trait assessments.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Margherita Prosperi, Elisa Santocchi, Elena Brunori, Angela Cosenza, Raffaella Tancredi, Filippo Muratori, Sara Calderoni
Summary: The prevalence of CD in school-aged children with ASD was not statistically different from the control population, indicating the potential utility of routine CD screening for this population.
Article
Multidisciplinary Sciences
Yujie Liang, Hong Yu, Xiaoyin Ke, Darryl Eyles, Ruoyu Sun, Zichen Wang, Saijun Huang, Ling Lin, John J. McGrath, Jianping Lu, Xiaoling Guo, Paul Yao
Summary: This study suggests that vitamin D deficiency may exacerbate autism-related phenotypes induced by maternal diabetes, primarily through epigenetic mechanisms.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)