Article
Biochemistry & Molecular Biology
Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. P. Manfredsson, Susan B. B. Powell, Davide Dulcis
Summary: This study investigated the mechanism of how nicotine-induced dopamine (DA) plasticity protects substantia nigra (SN) neurons against nigrostriatal damage in Parkinson's disease (PD). The results showed that chronic nicotine treatment led to upregulation of transcription factor Nurr1 and DA-synthesizing enzyme tyrosine hydroxylase (TH) in GABAergic neurons in the SN. Nicotine also reduced the number of alpha-synuclein-expressing neurons and rescued motor deficits in PD mice. Importantly, the activation of GABA neurons and Nurr1 overexpression were sufficient to mimic nicotine-mediated dopamine plasticity. This study provides insights into developing new strategies for neurotransmitter replacement in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ezia Guatteo, Nicola Berretta, Vincenzo Monda, Ada Ledonne, Nicola Biagio Mercuri
Summary: This article focuses on the functional properties of nigral dopaminergic neurons and summarizes the shared or unique features of neuronal dysfunction in different stages of PD animal models, with the goal of illustrating the functional modifications occurring in these neurons during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
E. Hill, R. Gowers, M. J. E. Richardson, M. J. Wall
Summary: The study indicates that oligomeric alpha-synuclein plays a significant role in Parkinson's disease, leading to functional impairment of dopaminergic neurons. Preincubation with the ATP-sensitive K+ channel inhibitor glibenclamide can effectively reduce the impact of alpha-syn aggregates.
Article
Clinical Neurology
Ada Ledonne, Mariangela Massaro Cenere, Emanuela Paldino, Vincenza D'Angelo, Sebastian Luca D'Addario, Nicolas Casadei, Annalisa Nobili, Nicola Berretta, Francesca R. Fusco, Rossella Ventura, Giuseppe Sancesario, Ezia Guatteo, Nicola Biagio Mercuri
Summary: Prolonged overexpression of alpha-synuclein has detrimental effects on the structural and functional properties of substantia nigra pars compacta dopamine neurons, including compromised soma and dendritic arborization, increased firing activity, and altered ion channel function.
MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Fabio Schifano, Simone Dell'Acqua, Stefania Nicolis, Luigi Casella, Enrico Monzani
Summary: The study explores the interplay between α-Synuclein (aS), dopamine (DA), and iron in Parkinson's disease etiology. At high DA:Fe molar ratios, the formation of the [Fe-III(DA)(2)](-) complex hinders the interaction with aS peptides. However, at lower ratios, the peptide competes with one of the two coordinated DA molecules. Post-translational modifications of the peptide, such as oxidation and phosphorylation, play crucial roles in aS aggregation and affinity for iron(III). Moreover, the presence of a membrane-like environment enhances the peptide's effect on DA oxidation and complex formation and decomposition.
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Review
Neurosciences
Khadga Raj, Pawandeep Kaur, G. D. Gupta, Shamsher Singh
Summary: Parkinson's disease is a progressive neurological disorder caused by the degeneration of dopaminergic neurons, possibly influenced by exposure to heavy metals and trace elements. These metals can enter the brain and lead to dopaminergic neuronal damage, triggering oxidative stress and protein accumulation.
NEUROSCIENCE LETTERS
(2021)
Article
Clinical Neurology
Fares Bassil, Anna Delamarre, Marie-Helene Canron, Nathalie Dutheil, Anne Vital, Marie-Laure Negrier-Leibreich, Erwan Bezard, Pierre-Olivier Fernagut, Wassilios G. Meissner
Summary: The study found higher IRS-1pS312 expression in both PD patients and a preclinical rat model, indicating brain insulin resistance in PD and supporting the repurposing of anti-diabetic drugs for PD treatment.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Cell Biology
Takuya Hikima, Christian R. Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Summary: Research suggests that somatodendritic dopamine release in the substantia nigra pars compacta autoinhibits the neuron that releases it.
Review
Biochemistry & Molecular Biology
Zhang-Li Wang, Lin Yuan, Wen Li, Jia-Yi Li
Summary: This review discusses the role of iron dyshomeostasis in Parkinson's disease and the impact of glial cell activation on iron death and neuronal loss. It also explores the effects of iron death on alpha-synuclein aggregation and the potential roles of different types of glial cells in mediating iron death. Additionally, the review examines current clinical trials targeting iron homeostasis in Parkinson's disease.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jacob K. Sterling, Tae-In Kam, Samyuktha Guttha, Hyejin Park, Bailey Baumann, Amir A.Mehrabani-Tabari, Hannah Schultz, Brandon Anderson, Ahab Alnemri, Shih-Ching Chou, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Joshua L. Dunaief
Summary: The aggregation and accumulation of a-synuclein drive neurodegeneration in Parkinson's disease (PD). Microglia activated by misfolded a-synuclein release interleukin 6 (IL-6), which induces changes in neuronal iron transcriptome and leads to cellular iron accumulation. The IL-6-mediated cellular iron sequestration response (CISR) contributes to synuclein-induced neurodegeneration in PD patients.
Article
Biotechnology & Applied Microbiology
Joy R. Paterson, Marikka S. Beecroft, Raminder S. Mulla, Deenah Osman, Nancy L. Reeder, Justin A. Caserta, Tessa R. Young, Charles A. Pettigrew, Gareth E. Davies, J. A. Gareth Williams, Gary J. Sharples
Summary: Limiting the availability of metal ions can restrict bacterial growth and proliferation. This study uncovers the metal deprivation effects imposed by different chelants on Escherichia coli, providing significant insights into the mechanism of growth inhibition by chelants.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Neurosciences
Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The study suggests a potential therapeutic target for Parkinson's disease in ZNHIT1, which can protect against dopaminergic degeneration and mitochondrial dysfunction induced by alpha-synuclein. Overexpression of ZNHIT1 increases cellular ATP synthesis and prevents impairments in mitochondrial function caused by alpha-synuclein.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Nagwa A. Meguid, Heba S. Hashem, Mohamed H. Ghanem, Samia A. Helal, Yuliya Semenova, Saher Hashem, Adel Hashish, Salvatore Chirumbolo, Ahmed M. Elwan, Geir Bjorklund
Summary: This study aimed to identify metabolic abnormalities in BCAAs and investigate the presence of epileptiform discharges in ASD patients. Results showed that various types of seizures can occur in ASD children and that ASD children have lower levels of BCAAs compared to neurotypical controls. Further research is needed to better understand ASD and evaluate the association between ASD, EEG changes, seizures, and BCAAs more reliably.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Article
Microbiology
Maryam Dadar, Saeed Alamian, Hanka Brangsch, Mohamed Elbadawy, Ahmed R. Elkharsawi, Heinrich Neubauer, Gamal Wareth
Summary: This study investigated antimicrobial resistance (AMR) and virulence-associated factors in Brucella isolates from humans and animals in Iran. B. melitensis was the most common species, while B. abortus was isolated from only one human case. The isolates showed intermediate or resistant phenotype patterns for certain antibiotics. Whole genome sequencing (WGS) identified several virulence-associated genes, but failed to determine classical AMR genes. The findings suggest a need for further investigation into the proteomic and transcriptomic levels of phenotypic resistance mechanisms.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Review
Chemistry, Medicinal
Amin Gasmi, Pavan Kumar Mujawdiya, Amine Nehaoua, Mariia Shanaida, Yuliya Semenova, Salva Piscopo, Alain Menzel, Volodymyr Voloshyn, Olena Voloshyn, Volodymyr Shanaida, Geir Bjorklund
Summary: The obesity pandemic is a pressing public health concern, with a projected increase in the number of obese or overweight individuals by 2025. Current strategies for treating obesity focus on patient-centered approaches including diet, behavior, medication, and surgery. However, there is a need for novel and more effective pharmaceutical drugs to assist with lifestyle modifications and better manage obesity.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Article
Public, Environmental & Occupational Health
Maryam Dadar, Hanka Brangsch, Saeed Alamian, Heinrich Neubauer, Gamal Wareth
Summary: Brucellosis is a common zoonotic disease in the Middle East, causing economic losses to the livestock industry and posing a great public health concern. This study analyzed the genetic diversity and distribution of Brucella spp. in Iran using whole genome sequencing technology. The results revealed a close relationship between Iranian strains and strains from neighboring and Middle East countries, emphasizing the importance of brucellosis control measures in Iran.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Article
Multidisciplinary Sciences
Faranak Abnaroodheleh, Anahita Emadi, Shojaat Dashtipour, Tariq Jamil, Amin Mousavi Khaneghah, Maryam Dadar
Summary: A cross-sectional study in industrial dairy cattle farms in Iran revealed the presence of Brucella spp., including Brucella abortus and Brucella melitensis, in the Alborz and Tehran provinces. The seroprevalence of brucellosis in these farms was significant, and the shedding of Brucella in the milk of seropositive cows posed a serious risk of transmission to humans. Therefore, comprehensive bacteriological and serological tests, including analysis of blood and milk samples, should be conducted in order to control the spread of the disease.
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Maryam Dadar, Ramin Tabibi, Saeed Alamian, Yohama Caraballo-Arias, Ezra Jonathan Mrema, Jane Mlimbila, Sashikala Chandrasekar, Kenesh Dzhusupov, Cholpon Sulaimanova, Lyailya Zh Alekesheva, Smagul A. Manar, Karlygash K. Toguzbayeva, Aseni Wickramatillake, Bahman Mirzaei
Summary: This review highlights the risk factors associated with brucellosis among different occupational groups and emphasizes the need for a One Health policy to evaluate the complex challenges of brucellosis. However, implementing One Health strategies in developing countries has proven to be challenging.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
