Review
Immunology
Jurgen Floege, Thomas Rauen, Sydney C. W. Tang
Summary: IgA nephropathy is the most common type of glomerulonephritis in Asia and the Western world. Optimal supportive care and cautious use of immunosuppression are mainstay treatments. The controversy surrounding immunosuppression and the importance of patient characteristics in treatment plans should be carefully considered.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Urology & Nephrology
Xue Zhang, Jicheng Lv, Pan Liu, Xinfang Xie, Manliu Wang, Dan Liu, Hong Zhang, Jing Jin
Summary: Poly-IgA immune complex formation and glomerular deposition play a key role in IgA nephropathy, and a novel ELISA method using recombinant CD89 for detecting these complexes was successfully established. Levels of poly-IgA were significantly higher in IgA nephropathy patients compared to healthy controls and non-IgA nephropathy controls. The poly-IgA index was associated with kidney function and response to treatment, showing good discrimination between IgA nephropathy and healthy controls.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Transplantation
Anna Duval, Sophie Caillard, Veronique Fremeaux-Bacchi
Summary: The complement system is vital for innate immunity but its excessive activation can contribute to kidney damage in glomerulonephritis, particularly in IgA nephropathy. Activation of the complement system is involved in the development and progression of IgA nephropathy. Understanding the mechanisms behind complement activation and its role in IgA nephropathy is important for developing targeted therapies. This review aims to discuss the proposed mechanisms of complement activation and explore the clinical implications and outcomes of complement inhibition in IgA nephropathy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Min Wei, Wei-yi Guo, Bo-yang Xu, Su-fang Shi, Li-jun Liu, Xu-jie Zhou, Ji-cheng Lv, Li Zhu, Hong Zhang
Summary: The study found that in a subset of patients with IgA nephropathy, there was co-deposition of collectin11 and IgA in the glomerular mesangium. In vitro experiments showed that IgA1 immune complexes from patients with IgA nephropathy could increase the secretion of collectin11 in mesangial cells and accelerate complement activation.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Immunology
Nicholas R. Medjeral-Thomas, H. Terence Cook, Matthew C. Pickering
Summary: The pathogenesis of IgA nephropathy is not completely understood, with complement activity playing an important role in the disease. Clinical trials of therapeutic complement inhibitors will provide insight into the importance of complement activity in IgA nephropathy, and further research into complement mechanisms is essential for improving patient management.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yun Guo, Haiqiang Zhang, Xueqing Yu
Summary: This study conducts a comprehensive analysis of publications related to complement in IgA nephropathy from 1991 to 2022. It reveals that complement activation contributes to IgAN and immunosuppression in IgAN is a research hotspot. China, Japan, and the United States are the leading countries in terms of publications, and England, University of Alabama Birmingham, and Robert J Wyatt are the most influential country, institution, and author in this field of research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Dongqing Wang, Changwei Wu, Sipei Chen, Yi Li, Li Wang, Yong Zhang, Guisen Li
Summary: This study investigated the distribution of complement in the urine of IgA nephropathy (IgAN) patients using LC-MS/MS and analyzed its correlation with clinical and pathological characteristics. The results showed that urinary complement in IgAN patients was significantly correlated with renal function, proteinuria, and renal tissue damage. This could provide potential biomarkers for monitoring IgAN and insights for therapeutic choices targeting the complement system in IgAN patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Surgery
Anna Duval, Jerome Olagne, Augustin Obrecht, Gabriela Gautier Vargas, Peggy Perrin, Bruno Moulin, Veronique Fremeaux-Bacchi, Sophie Caillard
Summary: Crescentic forms of IgA nephropathy are rare but can lead to rapid kidney failure. Complement inhibitors may be a rational treatment option for patients unresponsive to immunosuppressive therapy. We report a successful case of crescentic IgA nephropathy recurrence after kidney transplantation, in which eculizumab was used as a rescue therapy.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cell Biology
Jianliang Wu, Zhizhi Hu, Yuxi Wang, Danni Hu, Qian Yang, Yueqiang Li, Wei Dai, Fengming Zhu, Juan Yang, Meng Wang, Han Zhu, Liu Liu, Xiaofeng He, Min Han, Ying Yao, Guangchang Pei, Rui Zeng, Gang Xu
Summary: High intensity of glomerular C3 deposition is associated with the severity of renal lesions and predicts long-term poor renal survival for IgAN patients.
Article
Multidisciplinary Sciences
Shuhei Naka, Kaoruko Wato, Taro Misaki, Seigo Ito, Daiki Matsuoka, Yasuyuki Nagasawa, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano
Summary: Streptococcus mutans, a common cause of dental caries, can potentially induce IgAN in patients by expressing the Cnm protein, as evidenced by a study in rats where inoculation of Cnm-positive S. mutans led to severe dental caries and IgAN-like glomerulonephritis symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Samar M. Said, Alejandro Best Rocha, Anthony M. Valeri, Mohamad Sandid, Anhisekh Sinha Ray, Mary E. Fidler, Mariam Priya Alexander, Christopher P. Larsen, Samih H. Nasr
Summary: FGN-IgAN is a rare dual glomerulopathy, with clinical presentation and demographics closer to FGN than IgAN. Prognosis is guarded, with a median renal survival of 3.6 years.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Pediatrics
Sophie Schroda, Martin Pohl
Summary: Childhood and adolescence-onset IgA nephritis often leads to chronic glomerulonephritis with declining renal function. Evidence-based treatment recommendations for this age group are lacking. A study reported that corticosteroid treatment according to the German Society of Pediatric Nephrology recommendations resulted in significant improvement in most cases.
Article
Transplantation
Cynthia J. Willey, Rosanna Coppo, Franz Schaefer, Malgorzata Mizerska-Wasiak, Mohit Mathur, Michaela J. Schultz
Summary: This study determined the incidence and prevalence of immunoglobulin A nephropathy (IgAN) in Europe by analyzing high-quality data from national registries. The annual IgAN incidence was found to be 0.76 per 100,000 people, and the overall prevalence was 2.53 per 10,000 people.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Alexandra Cambier, Patrick J. Gleeson, Lilia Abbad, Fanny Canesi, Jennifer da Silva, Julie Bex-Coudrat, Georges Deschenes, Olivia Boyer, Marion Rabant, Tim Ulinski, Julien Hogan, Michel Peuchmaur, Laureline Berthelot, Renato C. Monteiro
Summary: Childhood IgA nephropathy (IgAN) is a complex disease with unclear pathogenesis. This study found that soluble CD89 plays a crucial role in the development of childhood IgAN and may serve as a potential biomarker and therapeutic target.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Jingyi Li, Ling Guo, Sufang Shi, Xujie Zhou, Li Zhu, Lijun Liu, Jicheng Lv, Hong Zhang
Summary: The study found that arteriolar microangiopathic (MA) lesions in IgA nephropathy (IgAN) patients are associated with complement deposition, increased levels of Gd-IgA1 and C3a, and rare genetic variations in complement-related genes.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Nicholas Rhys Medjeral-Thomas, Christopher Lawrence, Marie Condon, Bhrigu Sood, Paul Warwicker, Heather Brown, James Pattison, Sunil Bhandari, Jonathan Barratt, Neil Turner, H. Terence Cook, Jeremy B. Levy, Liz Lightstone, Charles Pusey, Jack Galliford, Thomas D. Cairns, Megan Griffith
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Richard W. Corbett, Sarah Blakey, Dorothea Nitsch, Marina Loucaidou, Adam McLean, Neill Duncan, Damien R. Ashby
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Transplantation
Rakesh Dattani, Peter Hill, Nicholas Medjeral-Thomas, Megan E. Griffith, Damien Ashby, Stephen McAdoo, Richard W. Corbett, Gaetano Lucisano, Jack Beadle, Kieran McCafferty, Andrew Frankel, David Thomas
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Urology & Nephrology
Nicholas R. Medjeral-Thomas, Tina Thomson, Damien Ashby, Anand Muthusamy, Margaret Nevin, Neill Duncan, Marina Loucaidou
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Urology & Nephrology
Candice Clarke, Gaetano Lucisano, Maria Prendecki, Sarah Gleeson, Paul Martin, Mahrukh Ali, Stephen P. McAdoo, Liz Lightstone, Damien Ashby, Rawya Charif, Megan Griffith, Adam McLean, Frank Dor, Michelle Willicombe, Maura Appelbe, Edwina Brown, Tom Cairns, Caroline Clerkin, Marie Condon, Richard W. Corbett, Jeremy Crane, Frank Dor, Neill Duncan, Claire Edwards, Fabiana Fernandes da Costa, Andrew Frankel, Dawn Goodall, Julie Harris, Sharon Harris, Paul Herbert, Peter Hill, Andreas Kousios, Jeremy B. Levy, Lian Liu, Marina Loucaidou, Kathleen Lynch, Nicholas Medjeral-Thomas, Dihlabelo Moabi, Anand Muthusamy, Margaret Nevin, Andrew Palmer, Darren Parsons, Virginia Prout, Sue Punzalan, Emma Salisbury, Eleanor Sandhu, Colin Smith, Roland Storey, Anisha Tanna, Katie Tansey, David Thomas, James Tomlinson, Vassilios Papalois, Phil Webster, Dejing Yang
Summary: While COVID-19 infection was more commonly diagnosed in waitlist patients, transplant recipients had a higher COVID-19-associated mortality rate, resulting in comparable overall mortality rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Urology & Nephrology
Nicholas R. Medjeral-Thomas, Matthew C. Pickering, H. Terence Cook
Summary: Recent studies highlight the significance of the complement pathway in kidney diseases, particularly in C3G and IgAN. The complement protein FHR5 plays a crucial role in these diseases, with implications for potential therapeutic strategies.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Immunology
Nicholas R. Medjeral-Thomas, Anne Troldborg, Annette G. Hansen, Jack Gisby, Candice L. Clarke, Maria Prendecki, Stephen P. McAdoo, Eleanor Sandhu, Liz Lightstone, David C. Thomas, Michelle Willicombe, Marina Botto, James E. Peters, Matthew C. Pickering, Steffen Thiel
Summary: This study investigated the increased susceptibility of non-white ethnicity and chronic kidney disease to COVID-19, finding that lectin pathway activation may influence the severity of the disease. Unique associations between recognition molecules of the lectin pathway and COVID-19, including severity, were identified in patients of Asian and White ethnicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Urology & Nephrology
Nicholas R. Medjeral-Thomas, Charles D. Pusey
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Viktoria Dotz, Alessia Visconti, Hannah J. Lomax-Browne, Florent Clerc, Agnes L. Hipgrave Ederveen, Nicholas R. Medjeral-Thomas, H. Terence Cook, Matthew C. Pickering, Manfred Wuhrer, Mario Falchi
Summary: This study found that the N-glycosylation of IgA1 and IgA2 in IgAN patients has multiple structural features associated with the disease and glomerular function. These features include differences in galactosylation, sialylation, bisection, fucosylation, and N-glycan complexity, as well as the association of IgA1 O-glycan sialylation with both the disease and glomerular function. The results suggest that IgA O- and N-glycopeptides may be promising targets for future investigations and potential noninvasive biomarkers for disease prediction and deteriorating kidney function.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Immunology
Nicholas R. Medjeral-Thomas, H. Terence Cook, Matthew C. Pickering
Summary: The pathogenesis of IgA nephropathy is not completely understood, with complement activity playing an important role in the disease. Clinical trials of therapeutic complement inhibitors will provide insight into the importance of complement activity in IgA nephropathy, and further research into complement mechanisms is essential for improving patient management.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Editorial Material
Urology & Nephrology
Nicholas R. Medjeral-Thomas
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Urology & Nephrology
Nicholas R. Medjeral-Thomas, Michelle M. O'Shaughnessy
ADVANCES IN CHRONIC KIDNEY DISEASE
(2020)
Correction
Urology & Nephrology
Nicholas Rhys Medjeral-Thomas, Christopher Lawrence, Marie Condon, Bhrigu Sood, Paul Warwicker, Heather Brown, James Pattison, Sunil Bhandari, Jonathan Barratt, Neil Turner, H. Terence Cook, Jeremy B. Levy, Liz Lightstone, Charles Pusey, Jack Galliford, Thomas D. Cairns, Megan Griffith
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Oscar Sabuz, Ana V. Marin, Daniel Chacon, Emilia Arjona, Jose R. Regueiro, Agustin Tortajada
MOLECULAR IMMUNOLOGY
(2019)
Article
Urology & Nephrology
Maria Prendecki, Candice Clarke, Nicholas Medjeral-Thomas, Stephen P. McAdoo, Eleanor Sandhu, James E. Peters, David C. Thomas, Michelle Willicombe, Marina Botto, Matthew C. Pickering
CLINICAL KIDNEY JOURNAL
(2020)