期刊
BIOPHYSICAL JOURNAL
卷 111, 期 7, 页码 1396-1408出版社
CELL PRESS
DOI: 10.1016/j.bpj.2016.08.035
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资金
- National Institute for Psychobiology in Israel
- Open University in Israel
- National Institutes of Health [R01-GM030376]
- [F31-NS081954]
G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the body. The discovery that these receptors are voltage-sensitive has changed our understanding of their behavior. The M2 muscarinic acetylcholine receptor (M2R) was found to exhibit depolarization-induced charge movement-associated currents, implying that this prototypical GPCR possesses a voltage sensor. However, the typical domain that serves as a voltage sensor in voltage-gated channels is not present in GPCRs, making the search for the voltage sensor in the latter challenging. Here, we examine the M2R and describe a voltage sensor that is comprised of tyrosine residues. This voltage sensor is crucial for the voltage dependence of agonist binding to the receptor. The tyrosine-based voltage sensor discovered here constitutes a noncanonical by which membrane proteins may sense voltage.
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