期刊
MEDICINAL RESEARCH REVIEWS
卷 40, 期 3, 页码 1084-1102出版社
WILEY
DOI: 10.1002/med.21644
关键词
drug delivery; nanotherapeutics; therapeutic targets; tumor microenvironment
资金
- Beijing Municipal Natural Science Foundation [7182126]
- Key Research Program of Frontier Sciences, CAS [ZDBS-LY-SLH039]
- National Basic Research Plan of China [2018YFA0208900]
- Beijing Municipal Science and Technology Commission Preclinical Program [Z161100000116026]
- National Postdoctoral Program for Innovative Talents [BX20180083]
- Beijing Nova Program Interdisciplinary Cooperation Project [Z181100006218136]
To better make nanomedicine entering the clinic, developing new rationally designed nanotherapeutics with a deeper understanding of tumor biology is required. The tumor microenvironment is similar to the inflammatory response in a healing wound, the milieu of which promotes tumor cell invasion and metastasis. Successful targeting of the microenvironmental components with effective nanotherapeutics to modulate the tumor microvessels or restore the homeostatic mechanisms in the tumor stroma will offer new hope for cancer treatment. We here highlight the progress in constructing nanotherapeutics to target or modulate the tumor microenvironment. We discuss the factors necessary for nanomedicines to become a new paradigm in cancer therapy, including the selection of drugs and therapeutic targets, controllable synthesis, and tempo-spatial drug release.
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