Article
Polymer Science
Cristiana Luminita Gijiu, Raluca Isopescu, Daniel Dinculescu, Maria Memecica, Manuela-Rossemary Apetroaei, Mirela Anton, Verginica Schroder, Ileana Rau
Summary: This study experimentally investigated and optimized the extraction of chitin from crab shells to obtain chitosan with a predefined deacetylation degree and molecular mass. By varying four parameters, including NaOH concentration, temperature, HCl concentration, and number of acidic treatments, the optimum operating conditions were determined. The results showed that a high deacetylation degree of chitosan can be achieved with 5% NaOH concentration and low temperatures, while high molecular mass chitosan can be obtained with a single step acidic treatment.
Review
Engineering, Multidisciplinary
Alia Tasnim Hazmi, Farah B. Ahmad, M. H. Maziati Akmal, Aliza Aini Md Ralib, Fathilah Binti Ali
Summary: This study reviews different experimental procedures for the chemical extraction of fungal chitosan and selects the most effective method using PROMETHEE-GAIA analysis. The microwave-assisted organic acid-alkaline treatment extraction method is found to be the most effective for fungal chitosan extraction.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Review
Polymer Science
Alessandro Pellis, Georg M. Guebitz, Gibson Stephen Nyanhongo
Summary: This review provides an overview of chitosan as an important raw material for various applications and discusses different sources, extraction and conversion techniques, inherent characteristics, and customization methods of chitosan. The review also explores the effects of degree of acetylation, degree of deacetylation, and molecular weight on the properties of chitosan.
Article
Chemistry, Applied
Xiaoqiang Song, Yan Zhao, Yunen Liu, Wenchang Zhang, Xiaoxue Yuan, Lei Xu, Jinsong Zhang
Summary: In this study, chitin/chitosan sponges with varying degrees of deacetylation were prepared and tested for their hemostatic properties. The chitosan sponge with a deacetylation degree of 48% exhibited the best hemostatic performance, demonstrating the importance of a specific ratio of acetyl amino and amino groups in activating the coagulation system and promoting platelet and erythrocyte adhesion.
CARBOHYDRATE POLYMERS
(2021)
Article
Spectroscopy
Andrej Dementjev, Vadimas Dudoitis, Andrius Gelzinis, Ona Gyliene, Rima Binkiene, Dalia Jasineviciene, Vidmantas Ulevicius
Summary: In this study, the deacetylation degree of chitin and chitosan samples was determined using a technique called coherent anti-Stokes Raman spectroscopy (CARS). The CARS response calibration curve was obtained by measuring chitin/chitosan samples with different deacetylation degrees. The capabilities of CARS microscopy were demonstrated by imaging the shell of the black soldier fly larvae and displaying the structural distribution of the deacetylation degree within the shell.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Engineering, Environmental
E. Aguila-Almanza, Sze Shin Low, H. Harnandez-Cocoletzi, A. Atonal-Sandoval, E. Rubio-Rosas, J. Violante-Gonzalez, Pau Loke Show
Summary: After the death of sand crabs, their body carapace can be used as a potential source of chitosan, providing health benefits to human beings. The treated samples showed uniform microscopic structures, good crystal structure, and quality suitable for potential biomedical applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Pawel Poznanski, Amir Hameed, Waclaw Orczyk
Summary: Chitosan, derived from chitin, has strong antifungal activity and is biodegradable, biocompatible, and non-toxic. Chitosan nanoparticles can enhance its antifungal activity. Various parameters, such as molecular weight, degree of deacetylation, acetylation pattern, concentration, and protonation of chitosan, affect its antifungal activity and nanoparticle properties. Understanding these parameters is important for designing environmentally friendly plant protection strategies.
Article
Chemistry, Applied
Eliana Lucanera, Sebastian Anbinder, Carlos Macchi, Alberto Somoza
Summary: This study presents an experimental investigation on the evolution of physicochemical, thermal and nanostructural properties of chitosan samples obtained from squid pens during the deacetylation treatment. Potentiometric titration, capillary viscosimetry, infrared spectroscopy, differential scanning calorimetry, and positron annihilation lifetime spectroscopy were employed for analysis. The results discuss the influence of deacetylation time on the deacetylation degree, molecular weight, thermal parameters, and nanohole size of different samples. The study explores a method for preparing chitosan matrices with tailored nanostructural characteristics for specific applications through the deacetylation process.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Jun Yang, Mingyue Shen, Yu Luo, Ting Wu, Huiliang Wen, Jianhua Xie, Mesona Chinensis
Summary: A novel kind of polyelectrolyte complex hydrogels, MCP-CH, was generated through physical crosslinking, with improved properties and stability as the deacetylation degree (DD) increased, along with enhanced microstructure.
CARBOHYDRATE POLYMERS
(2021)
Article
Multidisciplinary Sciences
Gengxin Hao, Yanyu Hu, Linfan Shi, Jun Chen, Aixiu Cui, Wuyin Weng, Kazufumi Osako
Summary: Chitosan obtained from swimming crab shells via subcritical water pretreatment had lower yield and molecular weight compared to those prepared via sodium hydroxide pretreatment, but exhibited similar molecular structures and better thermal stability. Subcritical water pretreatment showed potential for crustacean shell pretreatment and chitosan preparation.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Seham S. Alterary, Narguess H. Marei
Summary: Three fabricated chitosan loaded with fly ash films were developed in this study, which showed good thermal stability and water/fat binding capacities. The antibacterial potential of the films was also screened, opening up new possibilities for utilizing chitosan extracted from waste materials in biological applications.
Article
Chemistry, Multidisciplinary
Kiruthiga Periyannan, Hemamala Selvaraj, Balachandar Subbu, Muthukrishnan Pallikondaperumal, Ponmurugan Karuppiah, Jothi Ramalingam Rajabathar, Hamad Al-Lohedan, Sadhasivam Thangarasu
Summary: The exoskeleton waste of crabs, shrimp, and fish contains chitin, which can be extracted and utilized to produce chitosan, contributing to circular economy and waste management.
GREEN PROCESSING AND SYNTHESIS
(2023)
Article
Biochemistry & Molecular Biology
Shamala Mane, Ejaj Pathan, Santosh Tupe, Sneha Deshmukh, Deepika Kale, Vandana Ghormade, Bhushan Chaudhari, Mukund Deshpande
Summary: This study extracted cell wall chitosan from fungi of different taxonomic classes and evaluated their properties and antifungal activity. The findings suggest that nanoformulation of fungal chitosan with low molecular weight and high degree of deacetylation has potential in antifungal applications and is biocompatible.
Review
Biochemistry & Molecular Biology
Chayanaphat Chokradjaroen, Jiangqi Niu, Gasidit Panomsuwan, Nagahiro Saito
Summary: Researchers are exploring renewable materials like nature-derived polysaccharides to add value by changing chemical structures for specific properties. The solution plasma process offers a novel method for modifying polysaccharides like chitin and chitosan, aiming to reduce hazardous chemicals, simplify production steps, and acquire high-purified products. Intensive explanation of influencing parameters in the plasma process provides a guideline for modifying polysaccharides to address economic aspects and environmental concerns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Serap Namli, Ozge Guven, Feyza Nur Simsek, Anton Gradisek, Gulum Sumnu, Meryem Esra Yener, Mecit Oztop
Summary: Chitosan aerogels, obtained by (supercritical) CO2 drying of hydrogels, are novel adsorbents with large surface area and high porosity. The study investigates the combined effects of chitosan's molecular weight and degree of deacetylation on the properties of aerogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Lada Puntus, Konstantin Lyssenko, Ilya V. Taidakov, Francois Kajzar, Ileana Rau
Summary: The effects of molecules of substituted [2,2]paracyclophane on the field corona poling experiment of thin film of polymethyl methacrylate (PMMA) polymer were investigated. The mutual orientation of different substituents was found to impact the second order non-linear optical susceptibility. The phenyl substituted molecule exhibited the highest susceptibility value of 72.2 +/- 7.2 pm/V at a fundamental wavelength of 1064.2 nm. X-ray structure, absorption spectroscopy, and quantum chemical calculations were employed to discuss the obtained values.
Article
Polymer Science
Cristiana Luminita Gijiu, Raluca Isopescu, Daniel Dinculescu, Maria Memecica, Manuela-Rossemary Apetroaei, Mirela Anton, Verginica Schroder, Ileana Rau
Summary: This study experimentally investigated and optimized the extraction of chitin from crab shells to obtain chitosan with a predefined deacetylation degree and molecular mass. By varying four parameters, including NaOH concentration, temperature, HCl concentration, and number of acidic treatments, the optimum operating conditions were determined. The results showed that a high deacetylation degree of chitosan can be achieved with 5% NaOH concentration and low temperatures, while high molecular mass chitosan can be obtained with a single step acidic treatment.
Article
Pharmacology & Pharmacy
Violeta Popovici, Elena Matei, Georgeta-Camelia Cozaru, Laura Bucur, Cerasela Elena Gird, Verginica Schroder, Emma Adriana Ozon, Iulian Sarbu, Adina Magdalena Musuc, Irina Atkinson, Adriana Rusu, Simona Petrescu, Raul-Augustin Mitran, Mihai Anastasescu, Aureliana Caraiane, Dumitru Lupuliasa, Mariana Aschie, Victoria Badea
Summary: This study explores the potential use of Usnea barbata extract in oral cancer therapy. The formulated bioadhesive oral films containing the extract show favorable physical and chemical properties and exhibit anticancer activity. In vitro experiments demonstrate the extract's potential to induce apoptosis and inhibit DNA synthesis in oral cancer cells.
Article
Biochemistry & Molecular Biology
Violeta Popovici, Elena Matei, Georgeta Camelia Cozaru, Laura Bucur, Cerasela Elena Gird, Verginica Schroder, Emma Adriana Ozon, Adina Magdalena Musuc, Mirela Adriana Mitu, Irina Atkinson, Adriana Rusu, Simona Petrescu, Raul-Augustin Mitran, Mihai Anastasescu, Aureliana Caraiane, Dumitru Lupuliasa, Mariana Aschie, Victoria Badea
Summary: This study aims to develop mucoadhesive oral films loaded with Usnea barbata (L.) dry acetone extract as a potential therapy for oral squamous cell carcinoma (OSCC). The results showed that these films have suitable physical and structural characteristics and can be administered topically on the oral mucosa. They demonstrated significant anticancer effects on tumor cells, as well as antimicrobial activity against certain bacterial and fungal strains.
Article
Biochemistry & Molecular Biology
Violeta Popovici, Elena Matei, Georgeta Camelia Cozaru, Laura Bucur, Cerasela Elena Gird, Verginica Schroder, Emma Adriana Ozon, Oana Karampelas, Adina Magdalena Musuc, Irina Atkinson, Adriana Rusu, Simona Petrescu, Raul-Augustin Mitran, Mihai Anastasescu, Aureliana Caraiane, Dumitru Lupuliasa, Mariana Aschie, Victoria Badea
Summary: Usnea lichens possess pharmacological effects that can be beneficial in oral medicine. This study explores the use of Usnea barbata extract in canola oil as an oral pharmaceutical formulation. Bioadhesive oral films loaded with the extract were formulated, characterized, and evaluated, demonstrating their potential pharmacological effects. The films showed antimicrobial properties against certain bacteria and fungi, and also exhibited cytotoxic effects on oral cancer cells. These findings suggest that Usnea barbata extract-loaded bioadhesive oral films could be a valuable phytotherapeutic formulation for oral infections and neoplasia.
Article
Chemistry, Physical
Daniel Dinculescu, Cristiana Luminit Gijiu, Manuela Rossemary Apetroaei, Raluca Isopescu, Ileana Rau, Verginica Schroder
Summary: This study focuses on utilizing waste egg capsules of Rapana venosa as raw material to extract chitosan oligomers, with the aim of optimizing the extraction process. By using experimental design and neural modeling, a maximum yield of 7.05% was achieved with a NaOH concentration of 6.47%, temperature of 90 degrees C, and extraction duration of 120 min.
Article
Chemistry, Physical
Nicolaie Marin, Cristina Orbeci, Liliana Bobirica, Ileana Rau, Calin Deleanu, Elena Iuliana Biru, Paul Octavian Stanescu, Andrei Constantin Berbecaru, Ecaterina Matei, Constantin Bobirica
Summary: Solid activators based on waste glass were synthesized for the manufacture of one-part alkali-activated fly ash/red mud materials. The results showed that the reaction temperature significantly influenced the properties of the solid activators. The best water solubility and compressive strength were achieved for the solid activators synthesized at a temperature of 600 degrees Celsius.
Article
Polymer Science
Adrian Petris, Petronela Gheorghe, Ileana Rau
Summary: This study investigates the influence of DNA-CTMA matrix on the emission of Rhodamine 610 in thin films under 532nm laser illumination at different concentrations.
Article
Chemistry, Multidisciplinary
Irina Mihaela Iancu, Verginica Schroder, Manuela-Rossemary Apetroaei, Ruxandra Mihaela Cretu, Horatiu Miresan, Adina Honcea, Valeriu Iancu, Laura Adriana Bucur, Gabriela Mitea, Georgiana Atodiresei-Pavalache
Summary: This study demonstrates the potential of combining Lythri herba and chitosan to produce non-toxic, antibacterial and antithrombotic solutions and membranes for medical applications.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Andreea Roxana Ungureanu, Violeta Popovici, Camelia Oprean, Corina Danciu, Verginica Schroder, Octavian Tudorel Olaru, Dragos Paul Mihai, Liliana Popescu, Emanuela-Alice Luta, Carmen Lidia Chitescu, Cerasela Elena Gird
Summary: This research evaluated the cytotoxicity of three vegetal extracts on endothelial cells and brine shrimp larvae, and found that they can be safely used for human consumption and pharmaceutical formulations. Through molecular docking simulations and algorithm prediction, potential interactions between the extracts and phytocompounds related to apoptosis were discovered.
Article
Multidisciplinary Sciences
Adrian Petris, Petronela Gheorghe, Ileana Rau
Summary: This study reports on the influence of continuous wave laser light at 532 nm on the transmittance and photoluminescence of DNA-CTMA-RhB in butanol compound. The experimental investigation and analysis show the effect of DNA-CTMA on the light-induced process, as well as the temporal dependence of absorption changes induced by the laser light.
Article
Chemistry, Multidisciplinary
Alice Gianina Simonca, Madalina Georgiana Albu Kaya, Ileana Rau, Maria Minodora Marin, Cristina-elena Dinu-pirvu, Alina Lupuliasa, Mihaela Violeta Ghica
Summary: The purpose of this study was to obtain and characterize collagen-based hydrogels with different concentrations of metronidazole and strontium ranelate for periodontal therapy. The structural integrity of the hydrogels was evaluated using circular dichroism, and the release of metronidazole was investigated using an immersion cell adapted to USP 2 apparatus. The results showed that the collagen hydrogels with metronidazole preserved the integrity of the collagen triple helix, while the presence of strontium ranelate caused a structural alteration. The designed collagen-based hydrogels with metronidazole could be beneficial for periodontal disease treatment.
UNIVERSITY POLITEHNICA OF BUCHAREST SCIENTIFIC BULLETIN SERIES B-CHEMISTRY AND MATERIALS SCIENCE
(2023)
