Article
Pharmacology & Pharmacy
Patrick Latuske, Moritz von Heimendahl, Serena Deiana, Carsten T. Wotjak, Johann du Hoffmann
Summary: Cognitive flexibility is crucial for healthy functioning and is often impaired in neuropsychiatric diseases. Probabilistic reversal learning (PRL), a commonly used method to measure cognitive flexibility, is often limited in rodents. A novel rat PRL task that occurs at longer intervals demonstrates increased sensitivity to drugs, offering potential for testing and developing novel treatments for cognitive impairment in human patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yongwoo Jeong, Ho Jung Bae, Keontae Park, Hyo Jeoung Bae, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu
Summary: Scrophularia buergeriana may be a potential treatment for mental illness, especially schizophrenia, by supplying kidney Yin and reducing blood heat to alleviate symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Jae Youn Kim, Chang Hyeon Kong, Do Yeon Kim, Ji Won Min, Keontae Park, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jong Hoon Ryu
Summary: In this study, we investigated the potential of D-pinitol to ameliorate schizophrenia-like behaviors induced by MK-801. The results showed that single administration of D-pinitol improved sensorimotor gating deficits, social behavior deficits, and cognitive impairments induced by MK-801 without causing motor coordination deficits.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Ho Jung Bae, Jae Youn Kim, Seung-Hyuk Choi, So-Yeon Kim, Hyun-Jeong Kim, Ye Eun Cho, Yu-Yeong Choi, Ju-Yeon An, So-Young Cho, Jong Hoon Ryu, Se Jin Park
Summary: This study found that Cynanchum paniculatum has the potential to improve schizophrenia-like behaviors induced by MK-801, and paeonol, the major component, could be a treatment for schizophrenia. Paeonol can reverse prepulse deficits in acoustic startle response test, attenuate social novelty preference and novel object recognition memory. In addition, it can reverse abnormal signaling pathways and inflammatory factors in the prefrontal cortex.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Neurosciences
Jinwei Xu, Yaohao Li, Biqing Tian, Haiying Liu, Shengxi Wu, Wenting Wang
Summary: This article investigates the effect of environmental enrichment on cognitive symptoms in schizophrenia and explores the significance of NMDA receptor hypofunction in cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Jia-Quan Liang, Xi Chen, Yong Cheng
Summary: The study demonstrates that paeoniflorin can alleviate schizophrenia-like behaviors through inhibiting the oxidative stress pathway. The potential mechanisms of restoring neuronal expression and preventing neurotoxicity were also revealed.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zhu
Summary: Treatment with MK-801 enhances proliferation of hippocampal astrocytes and upregulates BDNF mRNA expression. The NMDA, PI3K, and ERK1/2 signaling pathways may be involved in regulating MK-801-induced BDNF upregulation. These findings suggest that astrocytes may play a role in the acute neurological and behavioral response to MK-801 treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Sema Oral, Gokhan Goktalay
Summary: By disrupting prepulse inhibition (PPI) modeling of schizophrenia, rats can be divided into different groups based on baseline PPI values, showing varying responses to pharmacological agents. Amphetamine disrupted PPI in both low and high inhibitory groups, while other agents only affected PPI levels in the high inhibitory group.
NEUROSCIENCE LETTERS
(2021)
Article
Psychiatry
Yushen Ding, Qing Tian, Wenpeng Hou, Zhenzhu Chen, Zhen Mao, Qijing Bo, Fang Dong, Chuanyue Wang
Summary: This study investigated the relationship between sensory gating and cognitive function in schizophrenia patients. It found impairments in both sensory gating and cognitive function, with the PSSPPI measure at 60 ms showing significant associations with clinical symptoms and cognitive performance.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Masahito Sawahata, Hiroki Asano, Taku Nagai, Norimichi Ito, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
Summary: The study showed that microinjection of recombinant Reelin into the medial prefrontal cortex prevented recognition memory impairment induced by MK-801, highlighting the potential therapeutic effects of Reelin on cognitive deficits associated with schizophrenia. Despite this positive effect, Reelin treatment did not ameliorate deficits in sensory-motor gating and short-term memory in the animal model of schizophrenia. The results suggest that Reelin acts on its receptors to suppress neural activity in the mPFC, thereby preventing cognitive deficits induced by MK-801.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Hyo Jeoung Bae, Ho Jung Bae, Jae Youn Kim, Keontae Park, Xingquan Yang, Seo Yun Jung, Se Jin Park, Dong Hyun Kim, Chan Young Shin, Jong Hoon Ryu
Summary: Schizophrenia is associated with neuroinflammation and elevated cytokine levels. Lansoprazole, a proton pump inhibitor, has been found to reduce neurotoxicity and inflammatory cytokines. This study investigated whether lansoprazole could ameliorate schizophrenia-like symptoms in mice. Results showed that lansoprazole improved sensorimotor gating deficits, spatial learning, and social deficits, without causing motor coordination deficits. Lansoprazole also decreased inflammatory cytokines in the cortex but not in the hippocampus. These findings suggest that lansoprazole could be a potential treatment for schizophrenia patients with specific symptoms, without motor-related adverse effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Environmental Sciences
Murat Sirri Akosman, Ruhi Turkmen, Hasan Huseyin Demirel
Summary: The study demonstrated that resveratrol has a protective effect against glial cell infiltration and shrinkage of nerve cell nuclei induced by MK-801 in the brain. However, it did not correct behavioral disorders and demyelination of schizophrenia. Resveratrol partially prevented oxidative damage but not significantly.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Bilgin Kaygisiz, Sule Aydin, Engin Yildirim, Ahmet Musmul, Kevser Erol, Fatma Sultan Kilic
Summary: Galangin has positive effects on cognitive deficits associated with schizophrenia, and it does not involve nicotinic, muscarinic, and serotonin-1(A) receptors. Galangin has antipsychotic-like effects without inducing catalepsy.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Neurosciences
Xin Huang, Yaohao Li, Haiying Liu, Jinwei Xu, Zehua Tan, Haoyang Dong, Biqing Tian, Shengxi Wu, Wenting Wang
Summary: The BLA-ACC circuit plays a major role in schizophrenia-like behaviors induced by MK-801. Modulating BLA-ACC projecting neurons can improve social and cognitive deficits in patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Plant Sciences
Ho Jung Bae, Jihyun Kim, Se Jin Jeon, Jaehoon Kim, Nayeon Goo, Yongwoo Jeong, Kyungnam Cho, Mudan Cai, Seo Yun Jung, Kyung Ja Kwon, Jong Hoon Ryu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jaehoon Kim, Jong Min An, Yuna Jung, Na Hee Kim, Youngwoong Kim, Dokyoung Kim
Summary: A new red-emitting hybrid material based on a single-benzene-based fluorophore (SBBF) and silica was reported for the first time. This material demonstrates bright emissions at a red wavelength, high stability, bio-imaging applicability, and antibacterial effects. These hybrid materials could potentially advance the development and applications of dye-hybrid materials in various fields.
Article
Materials Science, Biomaterials
Rae Hyung Kang, Jinju Park, Jieun Kim, Tamrin Chowdhury, Ji Hyeon Oh, Jaehoon Kim, Jaeha Shin, Minji Kim, Chul-Kee Park, Sungjun Lee, Ji Yeoun Lee, Dokyoung Kim
Summary: GBM is an aggressive malignant tumor that is difficult to regulate with conventional chemotherapy due to anatomical structure specificity, low drug targeting ability, and limited penetration depth. A study prepared four types of nanoparticles based on porous silicon nanoparticles incorporating PEG, iRGD peptide, and SIWV tetra-peptide, and evaluated their deep-tumor penetration abilities in different models. The SIWV tetra-peptide significantly enhanced the penetration depth of the nanoparticles and showed higher anticancer efficacy in therapeutic formulations, promising for nanotherapeutics and peptide-conjugated drugs for GBM.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Jaehoon Kim, Dokyoung Kim
Summary: In this study, we found that HEPES is capable of disaggregating amyloid plaques associated with Alzheimer's disease. Additionally, we demonstrated its sustained-release system for up to 2 weeks through hybridization with a biocompatible polymer, Eudragit S100.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Youngwoong Kim, Jong Min An, Jaehoon Kim, Tamrin Chowdhury, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Chul-Kee Park, Joonyoung F. Joung, Sungnam Park, Dokyoung Kim
Summary: This study developed a new fluorescent diagnostic probe with high selectivity and sensitivity for monitoring homocysteine. The probe showed rapid response and could predict the formation of glioblastoma at an early stage through sensing homocysteine in blood plasma.
ANALYTICA CHIMICA ACTA
(2022)
Article
Behavioral Sciences
Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ryu
Summary: Current antipsychotics have limited effects on the cognitive deficits of schizophrenia patients. In this study, a Toll-like receptor knockout mouse was used as a schizophrenia mouse model to evaluate the effects of repetitive training as a cognitive remediation therapy. The results showed that repetitive training improved memory retrieval and reversal learning ability in the Toll-like receptor knockout mice, and activated neuronal cells in specific brain regions. This study suggests that the Toll-like receptor knockout mouse is a useful tool for studying the neurobiological mechanisms of cognitive remediation in schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Analytical
Jong Min An, Jungyo Suh, Jaehoon Kim, Youngwoong Kim, Joo Yeon Chung, Hee Seung Kim, Sung Yong Cho, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong, Dokyoung Kim
Summary: In this study, the world's first in vitro cervical cancer diagnosis technology based on a urine test was developed and its effectiveness was verified. The fluorescence-based diagnostic method showed a high true-positive ratio (74%) for cervical cancer. It has advantages of simple equipment, small sample requirement, and short diagnosis time.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Rae Hyung Kang, Youngwoong Kim, Hye Ji Um, Jaehoon Kim, Eun-Kyoung Bang, Seung Geun Yeo, Dokyoung Kim
Summary: This study developed a novel nanoformulation to enhance the efficacy of photodynamic therapy for glioblastoma, with significant targeting ability and excellent biocompatibility.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Applied
Jaehoon Kim, Jong Min An, Youngwoong Kim, Ji Hye Jin, Sung Soo Kim, Rae Hyung Kang, Dokyoung Kim
Summary: A new synovium-homing tri-peptide, DRL, was developed through peptide screening and functionalized to visualize the synovium. The TAMRA-conjugated DRL, named DRL-TAM, demonstrated remarkable visualization ability on synovial-derived cells and synovial-related organs in cell screening and in vivo fluorescence imaging studies. This study opens up new possibilities for the diagnosis and treatment of synovium-related diseases.
Article
Chemistry, Multidisciplinary
Youngwoong Kim, Jaehoon Kim, Jong Min An, Chul-Kee Park, Dokyoung Kim
Summary: Fluorescence-guided surgery (FSG) is a surgical method that uses fluorescent materials to selectively visualize tumor sites. However, commercially available fluorescent materials have shown serious adverse effects. A new nontoxic fluorescent probe called NPO-o-Pyr has been developed for real-time human glioblastoma visualization. It has high specificity and sensitivity, fast response time, and high biocompatibility. NPO-o-Pyr can overcome the limitations of current fluorescent probes and become a new substitute in FSG.
Article
Engineering, Biomedical
Jaehoon Kim, Hyeji Um, Na Hee Kim, Dokyoung Kim
Summary: Recent research has shown that using porous silicon nanoparticles as a therapeutic platform can overcome Alzheimer's disease and deliver drugs to the brain. The study found that 6-amino-2-naphthalenesulfonic acid (ANA) is an effective compound that can disaggregate amyloid plaques. By loading ANA into porous silicon nanoparticles and targeting delivery, memory impairment in an Alzheimer's disease mouse model can be improved.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Organic
Yuna Jung, Ji Hye Jin, Youngseo Kim, Ji Hyeon Oh, Heechang Moon, Huisu Jeong, Jaehoon Kim, Yoon Kyung Park, Yohan Oh, Sungnam Park, Dokyoung Kim
Summary: In this study, a new fluorescent nanoprobe BMeS-Ali is developed for the visualization of lipid droplets (LDs). BMeS-Ali shows selective staining ability, excellent biocompatibility, and can be applied to the visualization of human fingerprints.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ji Hyeon Oh, Rae Hyung Kang, Jaehoon Kim, Eun-Kyoung Bang, Dokyoung Kim
Summary: This study presents an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles, which can release an anticancer drug for up to 2 weeks in various biological environments.
Article
Materials Science, Biomaterials
Jong Min An, Youngwon Ju, Jeong Hee Kim, Hyein Lee, Yuna Jung, Jaehoon Kim, Yong Jun Kim, Joohoon Kim, Dokyoung Kim
Summary: This study reveals the tumor alleviation properties of a nanozyme consisting of amine-terminated sixth-generation polyamidoamine dendrimers encapsulated with tiny platinum nanoparticles, showing potential for application in GBM-related basic research and clinical settings. By suppressing GBM cell migration, invasion, and adhesion, the nanozyme demonstrates its ability for tumor alleviation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Organic
Jaehoon Kim, Ji Hyeon Oh, Dokyoung Kim
Summary: Fluorescence-based materials and techniques have been widely studied and applied in various fields, especially in biology and materials science. The development of organic molecule-based fluorophores has contributed to the advancement of research in this area. Recent studies have focused on single-benzene-based fluorophores (SBBFs), exploring their physicochemical properties and applications for the development of new derivatives in the field of fluorophore-related materials science.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)