Editorial Material
Oncology
Lawrence D. True, Delphine L. Chen
Summary: Current imaging techniques for prostate cancer have limited sensitivity and specificity, but the novel PSMA agent F-18-DCFPyL-PET/CT shows promising performance.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisa Perry, Arpit Talwar, Sanjana Sharma, Daisy O'Connor, Lih-Ming Wong, Kim Taubman, Tom R. Sutherland
Summary: This study retrospectively reviewed 1445 F-18-DCFPyL PSMA PET/CT studies and found that the detection of non-prostate cancer tumors (NPCaT) using PSMA imaging was low. In contrast, atypical prostate cancer metastases showed intermediate to high PSMA expression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Ke-Hao Pan, Jin-Feng Wang, Chun-Ying Wang, Abdul Aziz Nikzad, Fang Q. Kong, Li Jian, Yin-Qiu Zhang, Xiao-Ming Lu, Bin Xu, Ya-Li Wang, Ming Chen
Summary: 18F-DCFPyL PSMA PET/CT has good sensitivity and specificity for diagnosing prostate cancer, with diagnostic rate correlated with PSA levels. Further large-scale, high-quality studies are needed in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther Mena, Steven P. Rowe, Joanna H. Shih, Liza Lindenberg, Baris Turkbey, Aloyse Fourquet, Frank I. Lin, Stephen Adler, Philip Eclarinal, Yolanda L. McKinney, Deborah E. Citrin, William Dahut, Bradford J. Wood, Richard Chang, Elliot Levy, Maria Merino, Michael A. Gorin, Martin G. Pomper, Peter A. Pinto, Janet F. Eary, Peter L. Choyke, Kenneth J. Pienta
Summary: This study investigated the factors predicting scan positivity and disease location in patients with biochemical recurrence of prostate cancer after primary local therapy. PSA and PSAdt were found to be independent predictors of scan positivity and disease location.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Mingels, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh, Ian Alberts
Summary: This study investigated the diagnostic accuracy of [F-18]PSMA-1007 PET/CT in biochemically recurrent prostate cancer. The results showed good performance in terms of regional sensitivity and negative predictive value, but limited positive predictive value, especially for bone lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. Celli, U. De Giorgi, P. Caroli, V Di Lorio, L. Fantini, V Rossetti, F. Foca, S. Nicolini, M. Giganti, G. Paganelli, F. Matteucci
Summary: This study evaluated the clinical value of (68)Ga-PSMA PET/CT negativity in patients with biochemical recurrent prostate cancer and found that ISUP subset was a significant risk factor for clinical relapse.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Fadi Khreish, Robert J. Marlowe, Andrea Schaefer-Schuler, Caroline Burgard, Stephan Maus, Sven Petto, Mark Bartholomae, Samer Ezziddin
Summary: Preliminary data suggest that using Zr-89-labeled PSMA ligand radiotracers may be more effective than using tracers with short-lived radionuclides in detecting suspicious lesions in patients with biochemical recurrence of prostate cancer. In this study, 78% of patients had suspicious lesions detected on 24-h and 48-h scans, with higher detection rates on the 48-h scans. This suggests that imaging at a later time may be preferable.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yining Wang, Yiping Shi, Yinjie Zhu, Lian Xu, Gang Huang, Jianjun Liu
Summary: Ga-68-PSMA PET/CT has a high detection rate in prostate cancer patients with biochemical recurrence, but few studies have explored other imaging methods for patients with negative Ga-68-PSMA findings. This study found that PSA level and Gleason score are independent predictors of F-18-FDG-positive findings, with patients with high PSA and Gleason score most likely to benefit from F-18-FDG PET/CT.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Paola Mapelli, Samuele Ghezzo, Cristiano Pini, Ana Maria Samanes Gajate, Alessandro Spataro, Carolina Bezzi, Claudio Landoni, Paola Scifo, Alberto Briganti, Arturo Chiti, Maria Picchio
Summary: Localized prostate cancer can be treated with radical intent via surgery, but biochemical recurrence is common in post-surgical follow-up. PSMA PET is an accurate diagnostic tool to detect disease recurrence. Predictors of PSMA PET positivity include higher pathological status after radical prostatectomy and high levels of PSA at the time of scan.
Article
Oncology
Shuoming Zhou, Tiantian Liu, Ziqiang Zhu, Lin Zhang, Subo Qian, Hongliang Fu, Qifeng Cao, Jian Kang
Summary: This study evaluates the predictive value of quantitative parameters of F-18-DCFPyL PET/CT in newly diagnosed PCa patients and finds that the P/M ratio may be a better parameter than SUVmax.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Florian Rosar, Caroline Burgard, Johannes Linxweiler, Mathias Wagner, Samer Ezziddin
Summary: We present an interesting image of testicular metastasis from prostate cancer using [Zr-89]Zr-PSMA-617 PET/CT imaging, in a 70-year-old man with biochemical recurrence and negative conventional [Ga-68]Ga-PSMA-11 PET/CT imaging. This case highlights the importance of considering [Zr-89]Zr-PSMA-617 PET/CT when conventional PSMA imaging fails to locate biochemical recurrence, and reminds colleagues of the rare but potential metastatic localization in this scenario.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela-Elena Oprea-Lager, Eric Gontier, Lina Garcia-Canamaque, Mathieu Gauthe, Pierre Olivier, Mercedes Mitjavila, Pilar Tamayo, Philippe Robin, Ana Maria Garcia Vicente, Anne-Charlotte Bouyeure, Alban Bailliez, Antonio Rodriguez-Fernandez, Sinan Ben Mahmoud, Juan Antonio Vallejo-Casas, Philippe Maksud, Charles Merlin, Paul Blanc-Durand, Clement Drouet, Hubert Tissot, Irina Vierasu, Thierry Vander Borght, Evelyne Boos, Florence Chossat, Marina Hodolic, Caroline Rousseau
Summary: The purpose of this study was to compare the per-patient detection rates of [F-18]DCFPyL and [F-18]fluoromethylcholine PET/CT in patients with first prostate cancer biochemical recurrence. The results showed that [F-18]DCFPyL had a significantly higher detection rate compared to [F-18]fluoromethylcholine.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Mark Bartholoma, Stephan Maus, Bastiaan M. Prive, Fadi Khreish, Gerben M. Franssen, Yvonne H. W. Derks, James Nagarajah, Samer Ezziddin
Summary: In this study, Ga-68-PSMA-11 PET/CT imaging and additional Zr-89-PSMA-617 PET/CT imaging were performed on a patient, revealing a small local recurrence in the prostate bed. This highlights the potential of Zr-89-labeled PSMA ligands, such as Zr-89-PSMA-617, in identifying the source of biochemical recurrence.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dennie Meijer, Pim J. van Leeuwen, Pepijn M. J. Oosterholt, Yves J. L. Bodar, Henk G. van der Poel, N. Harry Hendrikse, Maarten L. Donswijk, Maurits Wondergem, Annelies E. Vellekoop, R. Jeroen A. van Moorselaar, Jakko A. Nieuwenhuijzen, Daniela E. Oprea-Lager, Andre N. Vis
Summary: This study aimed to investigate the impact of F-18-DCFPyL PET/CT on the intended management of patients with biochemically recurrent hormone-sensitive prostate cancer. Positive F-18-DCFPyL PET/CT scan, positive pathological lymph node status, and negative surgical margin status were significantly associated with an increased likelihood of a change in management based on F-18-DCFPyL PET/CT findings.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Sara Harsini, Don Wilson, Heather Saprunoff, Hayley Allan, Martin Gleave, Larry Goldenberg, Kim N. Chi, Charmaine Kim-Sing, Scott Tyldesley, Francois Benard
Summary: This study examines the value of PSMA PET/CT-informed surgery and radiotherapy (RT) in patients with biochemical recurrence (BCR) treated without systemic therapy. The results suggest that RT or surgery based on PSMA PET/CT are associated with high PSA response rates. Further studies are needed to assess the impact of targeting these sites on patient relevant outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Syed M. S. Reza, Winston T. Chu, Fatemeh Homayounieh, Maxim Blain, Fatemeh D. Firouzabadi, Pouria Y. Anari, Ji Hyun Lee, Gabriella Worwa, Courtney L. Finch, Jens H. Kuhn, Ashkan Malayeri, Ian Crozier, Bradford J. Wood, Irwin M. Feuerstein, Jeffrey Solomon
Summary: This study employs deep-learning techniques to quantitatively analyze the CT scans of nonhuman primates exposed to SARS-CoV-2, specifically focusing on whole-lung and lung-lesion segmentation. Through the use of a novel multi-model ensemble technique, the automated segmentation of lung lesions is improved, demonstrating superior performance compared to other methods. The application of automated segmentation methods provides a standardized and automated approach for disease detection and quantification.
ACADEMIC RADIOLOGY
(2023)
Article
Infectious Diseases
Camila D. D. Odio, Kelsey E. E. Lowman, Melissa Law, Rosemary A. A. Aogo, Sally Hunsberger, Brad J. J. Wood, Michael Kassin, Elliot Levy, Viviane Callier, Saba Firdous, Chloe M. M. Hasund, Charlie Voirin, Robbie Kattappuram, Christina Yek, Jessica Manning, Anna Durbin, Stephen S. S. Whitehead, Leah C. C. Katzelnick
Summary: This study is a clinical trial conducted on healthy adults to investigate the impact of pre-vaccine host immunity on the safety and immunogenicity of dengue fever vaccines. By comparing immune responses before and after virus exposure, as well as after exposure to different serotypes, this research can help improve vaccine evaluations and expand potential target populations.
BMC INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Juan A. Esparza-Trujillo, William F. Pritchard, Michal Mauda-Havakuk, Matthew F. Starost, Paul Wakim, Johnathan Zeng, Andrew S. Mikhail, Ivane Bakhutashvili, Bradford J. Wood, John W. Karanian
Summary: In this study, cryoablation was characterized as a clinical intervention mode for adult woodchucks with hepatocellular carcinoma (HCC). The results showed that cryoablation was effective in causing necrosis and removing tumors in woodchucks with HCC.
COMPARATIVE MEDICINE
(2023)
Article
Engineering, Biomedical
Hengtao Guo, Hanqing Chao, Sheng Xu, Bradford J. Wood, Jing Wang, Pingkun Yan
Summary: This paper presents a novel deep learning approach, named deep contextual-contrastive network (DC2-Net), for sensorless ultrasound volume reconstruction from freehand 2D ultrasound scans without tracking information. The proposed method efficiently exploits content correspondence between ultrasound frames to estimate spatial movement and contrastive features and achieves superior performance compared with other methods, with a drift rate of 9.64% and a prostate Dice of 0.89. The promising results demonstrate the capability of deep neural networks for universal ultrasound volume reconstruction.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Review
Biology
Pataje G. S. Prasanna, Molykutty Aryankalayil, Deborah E. Citrin, C. Norman Coleman
Summary: This article investigates the mechanisms and potential biomarkers of radiation-induced pulmonary fibrosis (RIPF), as well as the roles of microRNAs (miRNA) and therapy-induced senescence (TIS) in the pathogenesis of RIPF.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Xi Fang, Xuanang Xu, James J. Xia, Thomas Sanford, Baris Turkbey, Sheng Xu, Bradford J. Wood, Pingkun Yan
Summary: In this paper, a set of shape description losses is proposed to supervise the training of segmentation networks. These losses extract and quantify geometric features of the targets, such as volume, surface area, center of mass, and bounding box. The results demonstrate that using these shape losses alone for weakly supervised learning can achieve promising performance.
MACHINE VISION AND APPLICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Enis C. Yilmaz, Joanna H. Shih, Mason J. Belue, Stephanie A. Harmon, Tim E. Phelps, Charisse Garcia, Lindsey A. Hazen, Antoun Toubaji, Maria J. Merino, Sandeep Gurram, Peter L. Choyke, Bradford J. Wood, Peter A. Pinto, Baris Turkbey
Summary: This study aimed to evaluate the performance of PI-RADS version 2.1 in prostate cancer detection and identify MRI features for improving csPCa detection. A total of 454 men who were suspected or known to have prostate cancer participated in this study. The results showed that csPCa rates varied among different PI-RADS categories, and MRI features including lesion volume, shape, and EPE scores could predict csPCa.
Correction
Multidisciplinary Sciences
Ayele H. Negussie, Andrew S. Mikhail, Joshua W. Owen, Natalie Hong, Camella J. Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L. Lewis, John W. Karanian, William F. Pritchard, Bradford J. Wood
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Cecilia Monge, Changqing Xie, Yuta Myojin, Kelley Coffman, Donna Mabry Hrones, Sophie Wang, Jonathan M. Hernandez, Bradford J. Wood, Elliot B. Levy, Israa Juburi, Stephen M. Hewitt, David E. Kleiner, Seth M. Steinberg, William D. Figg, Bernadette Redd, Philip Homan, Maggie Cam, Benjamin Ruf, Austin G. Duffy, Tim F. Greten
Summary: This study evaluated the safety and efficacy of the combination of PexaVec, durvalumab, and tremelimumab in patients with refractory pMMR mCRC. The results showed that the combination therapy has potential clinical activity without unexpected toxicities.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Li, Sherif Mehralivand, Sheng Xu, Nicole Varble, Ivane Bakhutashvili, Sandeep Gurram, Peter A. Pinto, Peter L. Choyke, Bradford J. Wood, Baris Turkbey
Summary: An augmented reality (AR) system was developed to facilitate real-time needle guidance for transperineal prostate (TP) procedures. The system uses preprocedural volumetric images to superimpose annotated anatomy onto a patient, providing real-time needle tip localization and visualization. The accuracy of the system was evaluated on a phantom, and the feasibility was further demonstrated by implanting soft tissue markers into a pelvic phantom. The results showed accurate needle guidance and the potential for more flexibility in TP procedures.
JOURNAL OF MEDICAL IMAGING
(2023)
Article
Acoustics
Hengtao Guo, Xuanang Xu, Xinrui Song, Sheng Xu, Hanqing Chao, Joshua Myers, Baris Turkbey, Peter A. Pinto, Bradford J. Wood, Pingkun Yan
Summary: In this study, a novel method for fusing ultrasound and magnetic resonance images using deep neural networks is proposed. The method is validated on a clinical dataset of 618 subjects and shows promising results in real-time navigation tasks.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Multidisciplinary Sciences
Nicole A. Varble, Ivane Bakhutashvili, Sheridan L. Reed, Jose Delgado, Zoi Tokoutsi, Bruno Frackowiak, Marco Baragona, John W. Karanian, Bradford J. Wood, William F. Pritchard
Summary: Heat-induced destruction of cancer cells via microwave ablation (MWA) is an effective treatment for liver cancer. Predicting the impacted zone of cell death is challenging, especially in the presence of vasculature. In order to improve thermal MWA for cancer treatment, an in vivo method and experimental dataset were created to assess biophysical models that can predict ablation zone parameters.
Meeting Abstract
Urology & Nephrology
Anjali Pillai, Zoe Blake, Daniel R. Nemirovsky, Jacob J. Enders, Neil Mendhiratta, Alexander P. Kenigsberg, Michael B. Rothberg, Jibriel Noun, Daniel Nethala, Sandeep Gurram, Bradford J. Wood, Baris Turkbey, Peter A. Pinto
JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim E. E. Phelps, Enis C. C. Yilmaz, Stephanie A. A. Harmon, Mason J. J. Belue, Joanna H. H. Shih, Charisse Garcia, Lindsey A. A. Hazen, Antoun Toubaji, Maria J. J. Merino, Sandeep Gurram, Peter L. L. Choyke, Bradford J. J. Wood, Peter A. A. Pinto, Baris Turkbey
Summary: This study evaluates the cancer detection rates of reduced-core biopsy schemes in patients with unilateral mpMRI-visible intraprostatic lesions and finds that the combined strategy of targeted biopsy and systematic biopsy maximizes the detection of clinically significant prostate cancer.
ABDOMINAL RADIOLOGY
(2023)
Article
Engineering, Biomedical
Neil Glossop, Reto Bale, Sheng Xu, William F. Pritchard, John W. Karanian, Bradford J. Wood
Summary: This study aimed to evaluate the feasibility of using personalized needle guidance grid templates for implementing in vivo ablation treatment plans with multiple needles. The personalized templates were fabricated using intraprocedural CT images, and multiple needle trajectories were planned. A numerical-controlled milling machine was used to drill the corresponding holes, and the needles were inserted to the calculated depth. The needle placement accuracy was high, and the procedure was performed rapidly.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)