Article
Psychology, Developmental
Jannath Begum-Ali, Amy Goodwin, Luke Mason, Greg Pasco, Tony Charman, Mark H. Johnson, Emily J. H. Jones
Summary: In this prospective study, alterations in the oscillatory electroencephalography profile, theta-beta ratio (TBR), were observed in infants with a family history of ADHD before the emergence of behavioral symptoms. These alterations were distinct from those commonly observed in older children with ADHD. The TBR alterations were specifically associated with ADHD and not observed in infants with a family history of ASD.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Review
Psychiatry
Abeer Al Lihabi
Summary: Sleep disturbance has a significant impact on neurodevelopmental disorders such as ASD, ADHD, and intellectual disability. The incidence of sleep problems in these patients is high, affecting their clinical presentation, daily function, and quality of life.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Xuemei Jin, Huilin Zhu, Wei Cao, Xiaobing Zou, Jiajia Chen
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 2% of children. A computer vision-based motion trajectory detection approach was proposed in this study to objectively extract movement features (MFs) from videos and evaluate children's activity levels in ASD assessment. The most relevant MFs were found to be the pixel distance (PD)-based MFs of all three body key points and the instantaneous pixel velocity (IPV)-based MFs of the right wrist key point in Table-play activity, which can be used as an auxiliary means for automating the evaluation of activity levels in ASD assessment.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Christoph Buehrer, Stefanie Endesfelder, Till Scheuer, Thomas Schmitz
Summary: Paracetamol, commonly used during pregnancy for fever and pain, is suspected to increase the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring by about 25% according to epidemiological studies. However, there are still unknown factors and mechanisms that require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Azadeh Kushki, Robyn E. Cardy, Sina Panahandeh, Mahan Malihi, Christopher Hammill, Jessica Brian, Alana Iaboni, Margot J. Taylor, Russell Schachar, Jennifer Crosbie, Paul Arnold, Elizabeth Kelley, Muhammad Ayub, Robert Nicolson, Stelios Georgiades, Jason P. Lerch, Evdokia Anagnostou
Summary: The study discovered associations between social communication abilities and distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, as well as three data-driven, diagnosis-agnostic subgroups based on the patterns of association in these networks.
Article
Medicine, General & Internal
Jian Yang, Xiaoyan He, Li Qian, Binbin Zhao, Yajuan Fan, Fengjie Gao, Bin Yan, Feng Zhu, Xiancang Ma
Summary: This study investigated the causal effects of plasma proteome on ASD, ADHD, and TS using the two-sample Mendelian Randomization approach. The findings indicate that increased levels of MAPKAPK3 and MRPL33 are associated with a higher risk of ASD, while increased MANBA levels are associated with a lower risk of ADHD. These causal associations were robust in sensitivity analysis, suggesting the involvement of the MAPK/ERK signaling pathway and mitochondrial dysfunction in the pathogenesis of ASD, and a role of beta-mannosidase deficiency in the development of ADHD.
Article
Multidisciplinary Sciences
Victor Ardulov, Victor R. Martinez, Krishna Somandepalli, Shuting Zheng, Emma Salzman, Catherine Lord, Somer Bishop, Shrikanth Narayanan
Summary: This research utilizes machine learning models and Q-learning algorithm to construct clinical tools with interpretability and robustness, aiding in complex clinical diagnoses. Through simulating the differentiation process of developmental disorders in children, it demonstrates how to train more robust classifiers by maximizing accuracy and minimizing information required.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Developmental
Giorgia Michelini, Agatha Lenartowicz, Joel P. Diaz-Fong, Robert M. Bilder, James J. McGough, James T. McCracken, Sandra K. Loo
Summary: This study found that the combination of d-methylphenidate and guanfacine can reduce midoccipital neural activity and improve symptoms in children with ADHD, while the monotherapy with these two drugs has limited effects and may have detrimental effects on performance. These findings are important for monitoring the treatment of children with ADHD in the future.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Article
Neurosciences
Grace R. Jacobs, Aristotle N. Voineskos, Colin Hawco, Laura Stefanik, Natalie J. Forde, Erin W. Dickie, Meng-Chuan Lai, Peter Szatmari, Russell Schachar, Jennifer Crosbie, Paul D. Arnold, Anna Goldenberg, Lauren Erdman, Stephanie H. Ameis
Summary: This study integrated brain imaging and behavioral measures to identify new brain-behavior subgroups cutting across autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD). The new groups showed significantly different scores on everyday adaptive functioning, indicating potential for studying data-driven groups representing children with neurodevelopmental disorders more similar to each other than others within their own diagnostic group.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Hye Jin Shin, Hyun Ju Lee, Dahyun Kang, Johanna Inhyang Kim, Eunju Jeong
Summary: This study aims to develop and validate a rhythm-based assessment and training program for children with ADHD, and to demonstrate its clinical effectiveness. The study will collect multifaceted data to customize training agendas based on individual developmental stages and prognoses.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Immunology
Andrea Pozo-Rodrigalvarez, Roosa Ollaranta, Jenny Skoog, Milos Pekny, Marcela Pekna
Summary: The C3a receptor plays a crucial role in neurodevelopment and cognitive functions in the adult brain, with its deficiency associated with abnormalities in neurodevelopment, including short-term memory deficits and increased locomotor activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Ancha Baranova, Jun Wang, Hongbao Cao, Jiang-Huan Chen, Jiu Chen, Miao Chen, Sulin Ni, Xijia Xu, Xiaoyan Ke, Shiping Xie, Jing Sun, Fuquan Zhang
Summary: This study uncovers the genetic relationships between ADHD and ASD, as well as their connections with extraversion. It also identifies novel shared genetic loci for ADHD and ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Thomas Donoghue, Natalie Schaworonkow, Bradley Voytek
Summary: Neural oscillations are prevalent and associated with cognitive tasks, offering an exciting opportunity to link theory, physiology, and mechanisms of cognition. However, careful consideration of the underlying assumptions of the methods used is necessary for proper interpretation of investigations into neural oscillations. Seven methodological considerations for analyzing neural oscillations are discussed, providing a helpful guide for measurement and interpretation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Thomas Donoghue, Bradley Voytek
Summary: Event-related potentials (ERPs) are a common method for studying the neural basis of cognition and disease. An automated text-mining approach was used for meta-analysis to examine relationships between ERP terms, cognitive domains, and clinical disorders. The project aims to create data-driven profiles for each ERP, analyze key associations of each component, compare similarities across components, and ultimately characterize patterns and associations between topics and components.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Leonhard Waschke, Thomas Donoghue, Lorenz Fiedler, Sydney Smith, Douglas D. Garrett, Bradley Voytek, Jonas Obleser
Summary: The study found that the spectral exponent of non-invasive EEG recording is sensitive to changes in E:I balance and can also track stimulus spectral exponents in auditory and visual sensory cortices. The degree of selective stimulus-brain coupling in spectral exponents predicted behavioral performance.
Article
Substance Abuse
Carol A. Dannenhoffer, Alexander Gomez-A, Victoria A. Macht, Rayyanoor Jawad, Elizabeth Blake Sutherland, Ryan P. Vetreno, Fulton T. Crews, Charlotte A. Boettiger, Donita L. Robinson
Summary: Adolescent intermittent ethanol exposure increases the expression of perineuronal nets (PNNs) in the adult prefrontal cortex (PFC), limiting the plasticity of PV interneurons and impairing frontostriatal microcircuitry and related behaviors.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychology, Developmental
Brendan Ostlund, Thomas Donoghue, Berenice Anaya, Kelley E. Gunther, Sarah L. Karalunas, Bradley Voytek, Koraly E. Perez-Edgar
Summary: This paper discusses the importance of the explicit parameterization of neural power spectra in cognitive neuroscience research, and introduces an automated spectral parameterization algorithm. The paper provides annotated code for power spectral parameterization and demonstrates its utility through an analysis of EEG data in children. Ultimately, the explicit parameterization of EEG power spectra helps refine our understanding of the impact of dynamic neural communication on cognition across the lifespan.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Editorial Material
Biochemical Research Methods
Bradley Voytek
Summary: This approach enables neuroscientists to integrate heterogeneous brain data and place it within a broader neuroscientific context.
Article
Neurosciences
Manuel R. Mercier, Anne-Sophie Dubarry, Francois Tadel, Pietro Avanzini, Nikolai Axmacher, Dillan Cellier, Maria Del Vecchio, Liberty S. Hamilton, Dora Hermes, Michael J. Kahana, Robert T. Knight, Anais Llorens, Pierre Megevand, Lucia Melloni, Kai J. Miller, Vitoria Piai, Aina Puce, Nick F. Ramsey, Caspar M. Schwiedrzik, Sydney E. Smith, Arjen Stolk, Nicole C. Swann, Mariska J. Vansteensel, Bradley Voytek, Liang Wang, Jean-Philippe Lachaux, Robert Oostenveld
Summary: Intracranial electroencephalography (iEEG) provides a detailed understanding of the human brain. This article critically reviews iEEG research practices, provides guidelines for newcomers, and addresses issues faced by experienced researchers. The paper covers data collection, electrode localization, preprocessing steps, signal analysis methods, statistical approaches, and unique perspectives on iEEG research. A glossary is also provided for consistent terminology.
Article
Neurosciences
Amanda Elton, John Hunter Allen, Mya Yorke, Farhan Khan, Peng Xu, Charlotte H. A. Boettiger
Summary: Childhood maltreatment (CM) and a family history (FH) of alcohol use disorder (AUD) interact in brain regions involved in impulsivity with sex-dependent effects. The study found that CM is associated with poorer response inhibition in males, but this effect is only observed in those with less FH. Furthermore, the results identified specific brain networks that are implicated in the relationship between FH, CM, and impulsivity. Overall, this study highlights the importance of considering sex-divergent effects and risk factors in understanding the expression of psychopathology.
HUMAN BRAIN MAPPING
(2023)
Review
Psychiatry
Jumana Ahmad, Claire Ellis, Robert Leech, Bradley Voytek, Pilar Garces, Emily Jones, Jan Buitelaar, Eva Loth, Francisco Pascoa dos Santos, Adrian F. Amil, Paul F. M. J. Verschure, Declan Murphy, Grainne McAlonan
Summary: Brain function is influenced by the balance between excitatory and inhibitory activity, and disruptions in this balance are thought to contribute to a range of neuropsychiatric conditions. However, there is a lack of validated methods for assessing excitatory and inhibitory function in humans. Recent research has identified novel EEG markers that could serve as proxy indicators of excitatory and inhibitory activity at specific neural levels.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Erik J. Peterson, Burke Q. Rosen, Aysenil Belger, Bradley Voytek, Alana M. Campbell
Summary: This paper investigated the differences in oscillatory and aperiodic activity between patients with schizophrenia and healthy controls during a target detection task. The steepness of the power spectrum better predicted group status than traditional band-limited oscillatory power. Aperiodic activity outperformed predictions made using participants' behavioral responses. The differences in aperiodic activity were highly consistent across all electrodes, suggesting it as a more accurate and robust way to differentiate patients with schizophrenia from healthy controls.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Claire Z. Han, Thomas Donoghue, Runnan Cao, Lukas Kunz, Shuo Wang, Joshua Jacobs
Summary: Investigations of hippocampal functions have yielded various findings, leading to debates about its core function and the nature of its representation. One promising research strategy to better understand hippocampal representations is the use of multi-task experiments, which involve switching between different task contexts while recording from the same neurons. This strategy, combined with explicitly defined theoretical motivations, could provide insights into how hippocampal representations support different behaviors and address fundamental questions about hippocampal function.
Article
Neurosciences
Thomas Donoghue, Runnan Cao, Claire Z. Han, Cameron Monteith Holman, Nicholas J. Brandmeir, Shuo Wang, Joshua Jacobs
Summary: Investigations into individual neurons encoding behavioral variables have revealed specific representations in single neurons, as well as a wide range of cells with conjunctive encodings or mixed selectivity. However, it is currently unclear if and how neural representations change across different task contexts. This study collected and analyzed single-neuron activity in the human medial temporal lobe during a paired-task session to investigate the variations in neuronal representations across different task contexts.
Article
Psychiatry
Sydney E. Smith, Vincent Ma, Celene Gonzalez, Angela Chapman, David Printz, Bradley Voytek, Maryam Soltani
Summary: This exploratory study on nine MDD patients shows that aperiodic activity increases with ECT treatment and better explains EEG slowing compared to power in oscillatory peaks. This increase in aperiodic activity is linked to increasing levels of inhibitory activity, suggesting that ECT may ameliorate depressive symptoms by restoring healthy levels of inhibition in frontal cortices.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Juan Molina, Joyce Sprock, Dylan Iwanaga, Jo Talledo, Yash Joshi, Bradley Voytek, Lisa Delano-Wood, Christopher Gonzalez, Steven Huege, Gabriel Leger, Greg Light, Neal Swerdlow
NEUROPSYCHOPHARMACOLOGY
(2022)