AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1

Pathological histone acetylation in Parkinson’s disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

(2018) Ian F. Harrison et al.   NEUROSCIENCE LETTERS

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

(2017) Gyun Jee Song et al.   Frontiers in Aging Neuroscience

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1

(2016) Jie Wang et al.   HEPATOLOGY

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

(2016) Amitabh Das et al.   Journal of Neuroinflammation

Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke

(2016) Xiao Qiang Xie et al.   MOLECULAR NEUROBIOLOGY

SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice

(2016) Ban Wang et al.   NEUROCHEMICAL RESEARCH

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

(2015) T. Zhao et al.   CURRENT MOLECULAR MEDICINE

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

(2015) Heyu Chen et al.   NEUROREPORT

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

(2015) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

(2014) Ae Sin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PET Radioligands for In Vivo Visualization of Neuroinflammation

(2014) Dieter Ory et al.   CURRENT PHARMACEUTICAL DESIGN

SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression

(2014) Y. J. Jung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitogen-Activated Protein Kinase Phosphatase 1 as an Inflammatory Factor and Drug Target

(2013) Riku Korhonen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions

(2012) Ahmed Lawan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE