Article
Neurosciences
Talanjeri Gopalakrishna Sahana, Katherine Johnson Chase, Feilin Liu, Thomas E. Lloyd, Wilfried Rossoll, Ke Zhang
Summary: Stress granules, RNA/protein condensates formed in cells under stress, are closely related to the pathogenesis of ALS and FTD. The most common genetic cause of these diseases is the mutation in the C9orf72 gene, which leads to the formation of toxic dipeptide repeats. In this study, it was found that the two most toxic dipeptide repeats, poly(GR) and poly(PR), activate the JNK pathway via the ER stress response protein IRE1, promoting stress granule assembly by inducing histone 3 phosphorylation and thus contributing to the neurodegeneration seen in C9ALS/FTD.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Rebekah Koppenol, Andre Conceicao, Ines T. Afonso, Ricardo Afonso-Reis, Rafael G. Costa, Sandra Tome, Diogo Teixeira, Joana Pinto da Silva, Jose Miguel Codesso, David V. C. Brito, Liliana Mendonca, Adriana Marcelo, Luis Pereira de Almeida, Carlos A. Matos, Clevio Nobrega
Summary: Koppenol et al. demonstrate that overexpression of G3BP1 reduces aggregation of ataxin-2 and ataxin-3 in cell models of SCA2 and SCA3. Lentiviral delivery of G3BP1 leads to improved motor function and neuropathology in preclinical models, suggesting its potential as a therapeutic target for polyQ disorders.
Article
Cell Biology
Saleena Alikunju, Nandita Niranjan, Maha Mohsin, Nazish Sayed, Danish Sayed
Summary: G3bp1 plays a critical role in regulating gene expression by controlling the levels of mature miR-1, and is crucial in hypertrophic stimuli.
CELLULAR SIGNALLING
(2022)
Article
Environmental Sciences
Tianqing Jiang, Xueying Qi, Ruqin Lin, Jun Jiang, Jikai Wen, Yiqun Deng
Summary: The T-2 toxin induces the formation of stress granules (SGs) while DON suppresses SG formation. SIRT1 co-localizes with SGs and regulates their formation by controlling the acetylation level of the SG nucleator G3BP1. The different effects of T-2 toxin and DON on SG formation are caused by changes in the activity of SIRT1.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Yanfei Wang, Wei Li, Cuiqiao Zhang, Wu Peng, Zhigang Xu
Summary: The study reveals that RBM24 is a component of stress granules (SGs) and can protect target mRNAs in stressed cells. Overexpression of RBM24 can induce SG formation, indicating its important role in SG formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Junjie Zhao, Xuhong Fu, Hao Chen, Lingqiang Min, Jie Sun, Jingyi Yin, Jianping Guo, Haojie Li, Zhaoqing Tang, Yuanyuan Ruan, Xuefei Wang, Yihong Sun, Liyu Huang
Summary: G3BP1 plays a significant role in gastric cancer chemoresistance, with its overexpression leading to poor outcomes in chemotherapy. Targeting G3BP1 can increase sensitivity of gastric cancer cells to chemotherapy drugs, promoting cell apoptosis.
BRITISH JOURNAL OF CANCER
(2021)
Review
Cell Biology
Matthew J. Brownsword, Nicolas Locker
Summary: Recent studies have revealed the mechanisms of how membrane-less organelles, called biocondensates, provide rapid response pathways in cells and interact with viral infections. The assembly of biocondensates is driven by the phase separation of their RNA and disordered protein components, which can be utilized by viruses for replication and counteracting antiviral activities.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Review
Biochemistry & Molecular Biology
Amir R. Afshari, Hamid Mollazadeh, Elmira Mohtashami, Arash Soltani, Mohammad Soukhtanloo, Azar Hosseini, Mohammad Jalili-Nik, Mohammad Mahdi Vahedi, Mostafa Karimi Roshan, Amirhossein Sahebkar
Summary: Despite therapeutic modalities available, GBM remains an incurable fatal disease, necessitating the exploration of additional treatment options. Nitric Oxide (NO) has been identified as a key player in GBM pathophysiology, involved in various processes. Natural products affecting the NO signaling pathway may offer potential as therapeutic targets for GBM.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Huan Zhou, Jing Luo, Kelin Mou, Lin Peng, Xiaoyue Li, Yulin Lei, Jianmei Wang, Sheng Lin, Yuhao Luo, Li Xiang
Summary: Stress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions. They play a highly conserved role in reducing stress-related damage and promoting cell survival. In recent years, SGs have been recognized as important players in cancer research, regulating various tumor-associated signaling pathways and suggesting novel directions for cancer treatment.
CELL AND BIOSCIENCE
(2023)
Article
Cell Biology
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu
Summary: The study demonstrated that Ciclopirox (CPX) exhibits strong anti-tumorigenic activity on glioblastoma multiforme (GBM) by inhibiting cellular migration and invasion, reducing the expression of Snail and N-Cadherin. Additionally, the combination of CPX and Bortezomib (BTZ) can promote apoptosis in GBM cells through reactive oxygen species (ROS)-mediated signaling pathways.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Xue Lu, Umber Alam, Charlene Willis, Derek Kennedy
Summary: The study showed that Chikungunya nsP3 disrupts stress granule (SG) formation, leading to increased cytotoxicity of the FDA approved drug bortezomib. The enhanced cytotoxicity appears to correlate with improved selectivity of bortezomib against cancer cells compared to control cell lines.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Hadjara Sidibe, Yousra Khalfallah, Shangxi Xiao, Nicolas B. Gomez, Hana Fakim, Elizabeth M. H. Tank, Genevieve Di Tomasso, Eric Bareke, Anais Aulas, Paul M. McKeever, Ze'ev Melamed, Laurie Destroimaisons, Jade-Emmanuelle Deshaies, Lorne Zinman, J. Alex Parker, Pascale Legault, Martine Tetreault, Sami J. Barmada, Janice Robertson, Christine Vande Velde
Summary: The study reveals that TDP-43 stabilizes G3BP1 transcripts, nuclear TDP-43 depletion is sufficient to reduce G3BP1 protein levels, and G3BP1 transcripts are reduced in neurons of ALS/FTD patients with TDP-43 cytoplasmic inclusions/nuclear depletion. These findings suggest that loss of function of TDP-43 and G3BP1 may contribute to ALS/FTD pathogenesis.
Article
Oncology
Shuhua Zheng, Wensi Tao
Summary: The study identified a simple three-gene transcriptome signature that can connect GBM's overall prognosis with gene expression, while also correlating perfusion imaging features with SOCS3 expression levels. SOCS3 expression levels are considered a potential selection marker for patients who may benefit from early initiation of angiogenesis inhibitors.
Article
Virology
Liumei Sun, Huan Chen, Xin Ming, Zongyi Bo, Hyun-Jin Shin, Yong-Sam Jung, Yingjuan Qian
Summary: The study revealed that PEDV infection induces the formation of stress granules (SGs) but this ability is lost as infection progresses. The cleavage of Ras-GTPase-activating protein-binding protein 1 (G3BP1) by caspase-8 during PEDV infection was identified, and cleavage-resistant G3BP1 inhibited viral replication while knockdown of G3BP1 enhanced viral replication. These findings provide new insights into the mechanisms of PEDV infection.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Raquel D. N. Arifa, Camila B. Brito, Talles P. Paula, Renata L. Lima, Zelia Menezes-Garcia, Puebla Cassini-Vieira, Fabricio A. Vilas Boas, Celso M. Queiroz-Junior, Janine M. da Silva, Tarcilia A. da Silva, Luciola S. Barcelos, Caio T. Fagundes, Mauro M. Teixeira, Daniele G. Souza
Summary: Eosinophils play an important role in chemotherapy-induced intestinal mucositis, and inhibiting eosinophils can alleviate inflammation. Evasin-4, a chemokine receptor antagonist, reduces the accumulation of eosinophils and chemotherapy-induced mucositis.
Article
Dentistry, Oral Surgery & Medicine
Vinicius Goncalves de Souza, Damilys Joelly Souza Santos, Ana Gabriela Silva, Rosy Iara Maciel de Azambuja Ribeiro, Adriano Mota Loyola, Sergio Vitorino Cardoso, Carla Silva Siqueira Miranda, Ludimila Paula Vaz Cardoso
Summary: In this study, the immunoexpression of PD-L1 was determined in lower lip squamous cell carcinomas (LLSCC) and actinic cheilitis (AC). The results showed that PD-L1 molecule may be a potential immune evasion mechanism in oral lesions, but the mechanisms differ between AC and LLSCC. The study highlights the importance of analyzing the tumor microenvironment and immune response in oral lesions.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Chemistry, Medicinal
Jonas P. Ramos, Mostafa A. L. Abdel-Salam, Daniel A. B. Nobre, Nicolas Glanzmann, Camila P. de Souza, Elaine A. Leite, Pedro P. de Abreu Teles, Alan S. Barbosa, Luciola S. Barcelos, Diego C. dos Reis, Geovanni D. Cassali, Maria E. de Lima, Quenia J. T. de Castro, Andrea Grabe-Guimaraes, Adilson D. da Silva, Elaine M. de Souza-Fagundes
Summary: Compounds developed from the 1,2,3-triazole scaffold were evaluated as novel drugs for TNBC treatment. Among them, derivative dhmtAc showed better solubility and cytotoxicity against TNBC. In vivo studies using a liposome formulation of dhmtAc showed no toxicity and reduced tumor growth in a murine model.
ARCHIV DER PHARMAZIE
(2022)
Article
Critical Care Medicine
Francyelle Borges Rosa de Moura, Bruno Antonio Ferreira, Elusca Helena Muniz, Allisson Benatti Justino, Ana Gabriela Silva, Rinara de Almeida Santos, Jose Augusto Leoncio Gomide, Rosy Iara Maciel de Azambuja Ribeiro, Daniele Lisboa Ribeiro, Fernanda de Assis Araujo, Foued Salmen Espindola, Tatiana Carla Tomiosso
Summary: The fraction rich in phenolic compounds (PCAc) extracted from the fruit peel of Annona crassiflora Mart. exhibited protective effects on fibroblasts and promoted wound healing by resolving inflammation, enhancing antioxidant defense, increasing collagen synthesis, and modulating metalloproteinases.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Pharmacology & Pharmacy
Francyelle Borges Rosa de Moura, Bruno Antonio Ferreira, Elusca Helena Muniz, Allisson Benatti Justino, Ana Gabriela Silva, Rosy Iara Maciel de Azambuja Ribeiro, Noelio Oliveira Dantas, Daniele Lisboa Ribeiro, Fernanda de Assis Araujo, Foued Salmen Espindola, Anielle Christine Almeida Silva, Tatiana Carla Tomiosso
Summary: This study demonstrated that Ag-ZnO/AgO nanoparticles have anti-inflammatory and antioxidant properties, and can accelerate wound healing. By reducing the inflammatory response, protecting tissues from damage caused by free radicals, and increasing collagen deposition, this nanocomposite material has the potential to improve the treatment of wounds.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Genetics & Heredity
Ana Carolina Carvalho-Silva, Almir Ribeiro Da Silva Junior, Vagner Oliveira-Carvalho Rigaud, Waleska Kerllen Martins, Veronica Coelho, Irmtraut Araci Hoffmann Pfrimer, Jorge Kalil, Simone Goncalves Fonseca, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira
Summary: Research has found that during Zika virus infection, miRNA levels are significantly decreased. miR-146, miR-125a-5p, miR-30-5p, and miR-142-3p are related to the modulation of signaling pathways during infection and immune response.
FRONTIERS IN GENETICS
(2022)
Article
Anatomy & Morphology
Roberta C. G. Espinosa, Anaira R. G. F. Costa, Marcelo A. Garcia Junior, Rosy I. M. de A. Ribeiro, Sergio Cardoso, Paulo R. de Faria, Adriano M. Loyola
Summary: This study analyzed the immunohistochemical expression of H3K9ac and H4K12ac in oral leukoplakia (OL) and found that alterations in H4K12ac occur in the early stages of OL. Both H3K9ac and H4K12ac may have a role in the regulation of epithelial cell proliferation in OL.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2022)
Review
Nutrition & Dietetics
Da Bin Kim, Do Kyeong Lee, Chunhoo Cheon, Rosy Iara Maciel A. Ribeiro, Bonglee Kim
Summary: Primary liver cancer ranks high in terms of diagnosis and mortality rates. Conventional treatments have limitations, leading to increased interest in natural compounds with anticancer effects and low adverse effects. This review examines in vivo studies and clinical trials on the effects of natural compounds on liver cancer, finding that they work through mechanisms such as apoptosis, anti-metastasis, and antiangiogenesis. Clinical trials also show improvements in liver cancer symptoms and patient survival rates with the use of natural products.
Article
Environmental Sciences
Keiza Priscila Enes dos Santos, Isabella Ferreira Silva, Brayan Jonas Mano-Sousa, Joaquim Mauricio Duarte-Almeida, Whocely Victor de Castro, Rosy Iara Maciel de Azambuja Ribeiro, Helio Batista Santos, Ralph Gruppi Thom
Summary: The study evaluated the effects of the pesticide abamectin on adult zebrafish through acute and chronic exposure. The results showed that abamectin caused morphological changes in the liver cells, decreased expression of HSP70 and P-gp, and affected the behavior patterns of the fish. This highlights the potential harm of indiscriminate pesticide use on non-target organisms.
Article
Biochemistry & Molecular Biology
Viviane A. O. Silva, Marcela N. Rosa, Izabela N. F. Gomes, Patrik da Silva Vital, Ana Laura V. Alves, Adriane F. Evangelista, Giovanna B. Longato, Adriana C. Carloni, Bruno G. Oliveira, Fernanda E. Pinto, Wanderson Romao, Allisson R. Rezende, Arali A. C. Araujo, Lohanna S. F. M. Oliveira, Alessandra A. M. Souza, Stephanie C. Oliveira, Rosy Iara Maciel A. Ribeiro, Rui M. Reis
Summary: This study evaluates the cytotoxic potential of 13 leaf extracts obtained from plants of 5 families found in the cerrado biome on a panel of 5 glioma cell lines and one normal astrocyte. The results reveal the cytotoxic activity of Melastomataceae species Miconia cuspidata, Miconia albicans, and Miconia chamissois, with the chloroform partition of M. chamissois showing the greatest cytotoxic activity. These findings suggest that the chloroform partition of M. chamissois could be a promising component for the development of new anticancer therapies.
Editorial Material
Pharmacology & Pharmacy
Rosy Iara Maciel Azambuja Ribeiro, Bonglee Kim
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lorena R. Sousa, Ana Gabriela S. Oliveira, Antonio Arantes, Joao Gabriel M. Junqueira, Gerso P. Alexandre, Vanessa G. P. Severino, Rui Manuel Reis, Bonglee Kim, Rosy I. M. A. Ribeiro
Summary: This study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart. against GBM cell lines. The fractions showed selective cytotoxicity to GBM cells compared to TMZ, and also inhibited cell migration, MMP-2 activity, and induced necroptosis-like morphological changes. These findings suggest that the fractions of A. coriacea Mart. should be further studied for potential GBM treatment.
Article
Biology
J. B. Netto, E. S. A. Melo, A. G. S. Oliveira, L. R. Sousa, L. R. Santiago, D. M. Santos, R. C. R. Chagas, A. S. Goncalves, R. G. Thome, H. B. Santos, R. M. Reis, R. I. M. A. Ribeiro
Summary: In this study, the anti-glioblastoma effect of the combination of matteucinol (Mat) with the chemotherapeutic TMZ was evaluated. The results demonstrated that this combination treatment showed selective cytotoxicity against tumor cells and reduced tumor growth.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Engineering, Biomedical
Gustavo F. Sousa, Samson Afewerki, Dalton Dittz, Francisco E. P. Santos, Daniele O. Gontijo, Sergio R. A. Scalzo, Ana L. C. Santos, Lays C. Guimaraes, Ester M. Pereira, Luciola S. Barcelos, Semiramis J. H. Do Monte, Pedro P. G. Guimaraes, Fernanda R. Marciano, Anderson O. Lobo
Summary: The use of click chemistry to engineer hydrogels allows for the creation of tailor-made hydrogels with desired mechanical and biocompatible properties. In this study, a versatile and facile catalyst-free click chemistry method was developed to generate a novel hydrogel by combining chondroitin sulfate and polyethylene glycol. The resulting hydrogel showed promising results for wound repair and in situ skin tissue engineering applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Chemistry, Medicinal
Filipe N. Franco, Julia T. Oliveira, Kimberly B. Tecchio, Flaviana A. Santos, Moacyr J. B. M. Rego, Francisco J. B. Mendonca-Junior, Maira G. R. Pitta, Michelly C. Pereira, Rosy I. M. A. Ribeiro, Vanessa J. S. V. Santos, Fabio V. Santos
Summary: This study evaluated the cytotoxic, genotoxic, and mutagenic properties of synthetic thiophenes in vitro using cell lines derived from human solid tumors. The results showed that these compounds have anti-proliferative effects against cancer cells and induce cell death by apoptosis. One compound showed a high selectivity towards tumor cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS
(2022)