期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 12, 页码 3242-3248出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00206
关键词
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资金
- China Postdoctoral Science Foundation [2018M631978]
- Heilongjiang Provincial Postdoctoral Science Foundation [LBH-Z18245]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2017221]
Melongenaterpenes A-L (1-12), 12 new sesquiterpenoids with rare spiro[4.5]decane skeletons, were isolated from the roots of Solanum melongena. Their 2D structures and relative configurations were determined based on NMR and HRESIMS data. The absolute configuration of melongenaterpene A (1) was defined by X-ray crystallographic analysis. The absolute configurations of the remaining compounds were determined by comparison of their NMR data with 1 and consideration of the biosynthetic pathway. This is the first report of the crystal structure of a vetispirane-type sesquiterpenoid. None of the compounds exhibited cytotoxic activity against the three human cancer cell lines HepG2, HeLa, and MCF-7.
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