Treatment of breast cancer with capped magnetic-NPs induced hyperthermia therapy

Treatment for different diseases has been revolutionized dramatically due to the advancements in the medical sciences, such as the practice of capped nanoparticles to treat carcinoma could be a promising strategy for future. For the first time we show that capping agents enhance the magnetization power while simultaneously reduce the particles size as well. Different capped iron oxide nanoparticles (Fe3O4-NPs) were synthesized using different organic ligands viz. citric acid and malic acid through coprecipitation method. Compared with un-capped particles, the capped-NPs exhibited reduction in size and cubic spinal structure as confirmed by TEM images and XRD peaks. Moreover, SEM images revealed that the organic acid functionalized NPs had irregular geometries in comparison with uncapped NPs. The presence of -OH -CH2 and -COOH groups were confirmed by FTIR and variations in magnetic field were recorded using VSM. For in vivo bioassay, capped magnetic NPs were injected inside tumor cells followed by exposure to alternating magnetic fields. Exposure to alternating magnetic field of 15 mT and frequency 100 kHz for 1 h caused rise in temperature from 37 to 48 degrees C and also resulted in cellular damage and subsequent apoptotic cell death. In an overall assessment, functionalized Fe3O4 -NPs exhibited reduction in particle size, increased magnetization properties and enhanced efficacy for carcinoma treatments by hyperthermia. (C) 2019 Elsevier B.V. All rights reserved.