期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 1, 页码 235-239出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.08.086
关键词
Antifungal compounds; Isocoumarin derivatives; Candida species
资金
- Serbian Ministry of Education, Science and Technological Development [172009, 173048]
A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved.
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