期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 1, 页码 218-221出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.10.085
关键词
Cycloalkane indoles; Antibacterial activity; MRSA; Structure-activity relationships
资金
- Egyptian Government
Antibiotic resistance is an ongoing problem in the treatment of bacterial diseases. Among the various antibacterial infections Staphylococcus aureus infections remain critical due to the increasing resistances, especially against the methicillin-resistant S. aureus (MRSA). We discovered novel antibacterial compounds with activities against both S. aureus and MRSA types. Structure-activity relationships (SAR) are discussed and show that the activity depends on the ring size of the anellated cycloalkane. Moreover, first substituent effects have been investigated for both the cycloalkane and the indole residues. (C) 2015 Elsevier Ltd. All rights reserved.
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