Article
Engineering, Biomedical
Xiang Liu, Qi Su, Huijuan Song, Xiaoguang Shi, Yuming Zhang, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Summary: The study demonstrates that PTT-induced in situ vaccination cancer therapy can effectively combat disseminated and metastatic tumors, showing promising anti-tumor immunity in mice. The use of gold nanorods covalently coupled with polyTLR7/8a and MMP-2-sensitive R9-PEG resulted in the formation of nanovaccines directly in vivo, activating dendritic cells and enhancing antitumor T-cell responses. Peritumoral administration of low-dose multifunctional AuNRs followed by noninvasive NIR laser irradiation inhibits local and distant metastatic tumors in mice, suggesting a potent therapeutic strategy for advanced cancers.
Article
Biochemistry & Molecular Biology
Nan Li, Yunfeng Sun, Jiabao Ouyang, Yuna Che, Chen Chen, Wen Li, Changjun Wu
Summary: In this study, a nanophotosensitizer based on nanobubbles and titanium nitride (TiN) was prepared for synergistic therapy for hepatocellular carcinoma. The UTND technology was utilized to enhance the penetration of TiN into tumor cells through ultrasound irradiation. The therapeutic effects and safety of the synergistic therapy were verified in vitro and in vivo.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ai-Lan Lin, Jia-Hui Chen, Jie-Wei Hong, Yuan-Yuan Zhao, Bi-Yuan Zheng, Mei-Rong Ke, Jian-Dong Huang
Summary: This study developed a highly efficient nanophotosensitizer NanoPcN-FA for photodynamic therapy, which demonstrated targeted effects on SKOV3 cells and efficient antitumor efficacy in vivo, with a tumor inhibition rate of 95%. Competitive assays confirmed the FR-mediated cellular uptake process of NanoPcN-FA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Grazia M. L. Consoli, Giuseppe Forte, Ludovica Maugeri, Valeria Consoli, Valeria Sorrenti, Luca Vanella, Gianpiero Buscarino, Simonpietro Agnello, Massimo Camarda, Giuseppe Granata, Loredana Ferreri, Salvatore Petralia
Summary: This study presents a novel method to prepare water-dispersible gold nanostructures with near-infrared localized surface plasmon resonance (LSPR) properties. These nanostructures were synthesized using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (CholCalix) forming micelles as a template. Characterization of the CholCalix-Au nanostructures was performed using UV-visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. The agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. The CholCalix-AuNPs demonstrated effective anticancer photothermal-induced effect on human breast cancer cells irradiated with biofriendly light at 808 nm.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Weiran Gao, Xiangyi Fan, Yunlong Bi, Zipeng Zhou, Yajiang Yuan
Summary: In this study, a near-infrared responsive gold nanocage carrier was designed and synthesized to control the release of Epigallocatechin gallate (EGCG) for inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. The nanomedicine demonstrated photothermal response and stability, leading to the promotion of HCC cell apoptosis. This study provides valuable insights into the potential of near-infrared responsive gold nanocage EGCG as a new type of nanomedicine for HCC.
FRONTIERS IN CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Jihui Wang, He Zhao, Wenjing Song, Mingyang Gu, Yujia Liu, Bingnan Liu, Honglei Zhan
Summary: The article introduces a promising multifunctional nanocarrier that integrates chemotherapy and photothermal therapy to enhance anticancer efficacy, sensitize drug-resistant cancer cells, and diminish cancer stem cells.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Fang Tang, Aixiang Ding, Yao Xu, Yingsong Ye, Lin Li, Rongjun Xie, Wei Huang
Summary: The integration of gene therapy and photothermal therapy offers a promising approach for cancer treatment, providing rapid response and improved effectiveness. Recent advancements in this field have resulted in notable achievements and progress towards potential clinical applications. However, challenges and future developments still need to be addressed. This comprehensive review explores the synergistic mechanisms, material systems, imaging-guided therapy, and anticancer applications of gene therapy and photothermal therapy integration, aiming to inspire further research in this promising area.
Review
Biotechnology & Applied Microbiology
Tania Ferreira-Goncalves, David Ferreira, Hugo A. Ferreira, Catarina P. Reis
Summary: The properties of gold nanoparticles (AuNPs) depend on the production method used, and these distinct properties have potential applications in biomedicine for diagnostic and therapeutic approaches. Multiple production methods for AuNPs have been explored, leading to their usefulness in various biomedical applications.
Article
Chemistry, Applied
Dongxin Wang, Xingchen Mu, Xin Chen, Heyong Huang, Lin Zhou, Shaohua Wei
Summary: The study utilized PCD as a linker to combine transition metal nanomaterials with functional molecules for synergistic photothermal and photodynamic tumor therapy.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Oleksii O. Peltek, Timofey E. Karpov, Anna Rogova, Alisa Postovalova, Eduard Ageev, Andrey Petrov, Dmitri Antuganov, Andrei A. Stanzhevsky, Dmitri N. Maistrenko, Dmitry Zuev, Albert R. Muslimov, Alexander S. Timin, Mikhail Zyuzin
Summary: Conventional cancer therapy has limitations due to nonspecific action of anticancer drugs, but combining radio and photothermal therapy with nanocarriers can achieve complete tumor inhibition. The nanocarriers can be effectively labeled with 188Re therapeutic radionuclide and converted into heat with laser irradiation. Combined with paclitaxel, the treatment efficiency is significantly improved compared to monotherapy, showing potential for clinical translation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Jesus E. Marquez-Castro, Angel Licea-Claverie, Jacob Licea-Rodriguez, Leidy P. Quiroga-Sanchez, Eugenio R. Mendez
Summary: A series of diblock copolymers containing a biocompatible PEG block and a thermoresponsive PNVCL-based block were synthesized by RAFT polymerization. The cloud point temperature (Tcp) was adjusted from 35 to 42 degrees C by adding NVP units in the thermoresponsive block. The gold nanorods were stabilized with the copolymers through grafting, and the temperature-dependent aggregation of the copolymer@GNRDs has potential applications in drug-delivery for photothermal therapy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biophysics
Bao Jiang, Liping Wang, Gang Wu, Lin Zhou, Shaohua Wei
Summary: Researchers have successfully synthesized a core-shell CDT drug FeCNB, which achieves high-efficiency CDT under physiological pH conditions through the galvanic cell structure formed in physiological electrolyte solution. FeCNB not only has T2-magnetic resonance imaging function and photothermal conversion ability, but also improves the CDT effect through tumor heating to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Lijun Wang, Binita Shrestha, Eric M. Brey, Liang Tang
Summary: This study developed a multifunctional therapeutic nanocomposite system using gold nanorods and gold nanoclusters, which demonstrated good stability and effective treatment for breast cancer cells through a combination of photothermal therapy and chemotherapy.
Review
Chemistry, Multidisciplinary
Masoud Nejabat, Ali Samie, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: Gold nanorods (GNRs/AuNRs) are versatile gold nanoparticles that can be easily modified for biocompatible and functional nano-agents in cancer therapy. Their specific properties, such as absorption in the near-infrared (NIR) region, make them suitable for thermal ablation of cancer cells and induction of various therapeutic approaches. This review comprehensively summarizes the anticancer therapeutic capacities of AuNRs and their roles in the fabrication of different nano-constructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Aleksandra Pilch-Wrobel, Lukasz Marciniak, P. James Schuck, Artur Bednarkiewicz
Summary: Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Piotr Pawlik, Barbara Blasiak, Joanna Depciuch, Marcin Pruba, Diana Kitala, Svetlana Vorobyova, Malgorzata Stec, Maxim Bushinsky, Artem Konakov, Jaroslaw Baran, Julia Fedotova, Oleg Ivashkevich, Magdalena Parlinska-Wojtan, Alexey Maximenko
Summary: The novel iron-oxide nanoparticles stabilized with triethanolammonium oleate were found to have potential applications in MRI-guided hyperthermia and regenerative medicine.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Spectroscopy
Joanna Depciuch, Magdalena Parlinska-Wojtan, Kursat Rahmi Serin, Huri Bulut, Engin Ulukaya, Nevzat Tarhan, Zozan Guleken
Summary: This study investigated the use of Raman spectroscopy as a promising analytical tool in medical diagnostics and a method to distinguish between healthy individuals and those with cholangiocarcinoma. The results showed that there were differences in the Raman spectra of amino acids, proteins, and lipid vibrations between healthy individuals and cancer patients. Specific ranges in the Raman spectra were identified as effective in distinguishing between the two groups.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Zozan Guleken, Huri Bulut, Berk Bulut, Wieslaw Paja, Barbara Orzechowska, Magdalena Parlinska-Wojtan, Joanna Depciuch
Summary: This study investigated the potential diagnostic tool of Raman spectroscopy for polycystic ovarian syndrome (PCOS) and found that Raman shifts of amides and CH2, CH3 lipid groups could be potential PCOS markers. The study also revealed a strong correlation between hormones and lipids, as well as between hormones and protein functional groups in PCOS women. These findings provide new insights into the diagnosis and treatment of PCOS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Zozan Guleken, Huri Bulut, Berk Bulut, Wieslaw Paja, Magdalena Parlinska-Wojtan, Joanna Depciuch
Summary: Endometriosis refers to the formation of the uterus lining outside the uterus. Raman spectroscopy analysis of serum showed that it is possible to distinguish between healthy women and those with endometriosis using specific Raman ranges. Lipid vibrations may serve as spectral markers of the disease.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Infectious Diseases
Ewelina Piktel, Urszula Wnorowska, Joanna Depciuch, Dawid Lysik, Mateusz Ciesluk, Krzysztof Fiedoruk, Joanna Mystkowska, Magdalena Parlinska-Wojtan, Paul A. Janmey, Robert Bucki
Summary: By modulating the EPS matrix, peanut-shaped gold nanoparticles showed significant efficiency in inhibiting the growth of Pseudomonas aeruginosa biofilms, especially when combined with NAC. The gold nanopeanuts not only reduced the viscosity of biofilms, but also increased their creep compliance. Additionally, AuP NPs exhibited synergistic effects with tobramycin, capable of eradicating antibiotic-resistant bacteria within biofilms.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
J. Depciuch, M. Stec, A. Maximienko, J. Baran, M. Parlinska-Wojtan
Summary: This study found that the size of gold nanoparticles affects their photothermal conversion efficiency, which can be correlated with the absorption/extinction ratios calculated by the Mie theory. Moreover, it revealed the photosensitizing properties of gold nanoparticles in photothermal cancer therapy and found that nanoparticle size affects cell death and changes in DNA, phospholipids, proteins, and cholesterol structures.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Spectroscopy
Joanna Depciuch, Pawel Jakubczyk, Wieslaw Paja, Jaromir Sarzynski, Krzysztof Pancerz, Merve Acikel Elmas, Elif Keskinoz, Ozlem Bingol Ozakpinar, Serap Arbak, Gokce Ozgun, Sevde Altuntas, Zozan Guleken
Summary: In this study, the modulatory effects of Apocynum on MSG-induced oxidative damage in rat brain tissue were examined using biochemical assays, FTIR, and machine learning methods. The results showed that Apocynum treatment protects against MSG-induced oxidative damage by inhibiting reactive oxygen species and upregulating antioxidant capacity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Environmental Sciences
Ewa Szpunar-Krok, Joanna Depciuch, Barbara Drygas, Marta Janczak-Pieniazek, Katarzyna Mazurek, Renata Pawlak
Summary: Field studies conducted from 2016 to 2019 in south-eastern Poland revealed that the chemical composition of winter wheat grain can be altered by the application of biostimulants and hydro-thermal conditions. Biostimulants containing salicylic acid and nettle extracts show promise as a potential alternative to synthetic crop protection products.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Monika Kula-Maximenko, Kamil Jan Zielinski, Joanna Depciuch, Janusz Lekki, Marcin Niemiec, Ireneusz Slesak
Summary: In this study, the SOD activity in Synechocystis sp. PCC 6803, Gloeobacter violaceus CCALA 979, and Geitlerinema sp. ZHR1A was analyzed using selective spectroscopic techniques. The results showed the presence of different forms of FeSOD in these cyanobacteria, while no active Cu/ZnSOD was identified. This study has important implications for understanding the activity and evolution of SOD in cyanobacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physics, Multidisciplinary
Jakub Szlachetko, Jacek Szade, Edyta Beyer, Wojciech Blachucki, Piotr Ciochon, Paul Dumas, Kinga Freindl, Grzegorz Gazdowicz, Sebastian Glatt, Krzysztof Gula, Josef Hormes, Paulina Indyka, Agnieszka Klonecka, Jacek Kolodziej, Tomasz Kolodziej, Jozef Korecki, Pawel Korecki, Filip Kosiorowski, Karolina Kosowska, Grzegorz Kowalski, Maciej Kozak, Paulina Koziol, Wojciech Kwiatek, Danuta Liberda, Henning Lichtenberg, Ewa Madej, Anna Mandziak, Andrzej Marendziak, Krzysztof Matlak, Alexey Maximenko, Pawel Nita, Natalia Olszowska, Roman Panas, Ewa Partyka-Jankowska, Marcel Piszak, Alexander Prange, Michal Rawski, Maciej Roman, Marcin Rosmus, Marcin Sikora, Joanna Slawek, Tomasz Sobol, Katarzyna Sowa, Nika Spiridis, Joanna Stepien, Magdalena Szczepanik, Tomasz Slezak, Tolek Tyliszczak, Grzegorz Wazny, Jaroslaw Wiechecki, Dorota Wilgocka-Slezak, Barbara Wolanin, Pawel Wrobel, Tomasz Wrobel, Marcin Zajac, Adriana Wawrzyniak, Marek Stankiewicz
Summary: The SOLARIS synchrotron in Krakow, Poland is a third-generation light source operating at medium electron energy. It was first observed in 2015, and experiments using soft X-ray energies were conducted in 2018. SOLARIS is now expanding its operation to include hard X-rays and is continuously developing its beamlines and infrastructure. This article provides an overview of the SOLARIS synchrotron design, including the beamlines, research infrastructure, performance parameters, and future development plans.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Oncology
Bartosz Klebowski, Malgorzata Stec, Joanna Depciuch, Agnieszka Panek, Dawid Krzempek, Wiktor Komenda, Adrianna Galuszka-Bulaga, Anna Pajor-Swierzy, Jarek Baran, Magdalena Parlinska-Wojtan
Summary: In this study, bimetallic PdPt nanoparticles with different nanostructures were prepared and their radiosensitizing properties were evaluated. The results showed that nano-alloy PdPt nanoparticles exhibited better enhancement of radiation-based therapy compared to PtPd core-shell nanoparticles. This research suggests the potential application of PdPt nanoparticles in improving the effectiveness of radiation-based anticancer therapies.
Article
Immunology
Malgorzata Stec, Marcin Czepiel, Marzena Lenart, Agata Piestrzynska-Kajtoch, Jacek Plewka, Agnieszka Bieniek, Kazimierz Weglarczyk, Rafal Szatanek, Magdalena Rutkowska-Zapala, Zofia Gula, Anna Kluczewska, Jaroslaw Baran, Mariusz Korkosz, Maciej Siedlar
Summary: Spondyloarthropathies (SpA) are a family of rheumatic disorders that can be divided into axial (axSpA) and peripheral (perSpA) sub-forms. This study identified specific miRNAs in monocyte subpopulations that could potentially differentiate between SpA and healthy individuals, as well as between different subtypes of SpA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Laskowska, Agnieszka Karczmarska, Mateusz Schabikowski, Michal Adamek, Alexey Maximenko, Katarzyna Pawlik, Oliwia Kowalska, Zbigniew Olejniczak, Lukasz Laskowski
Summary: The effects of synthesis conditions on the size and structure of synthetic opals were investigated using the Stober process. The internal hierarchical structure of the resulting silica particles was confirmed, and the study showed no dependence on the concentration of reagents and the size of the particles. This research is significant for the synthesis and application of synthetic opals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Huri Bulut, Nevzat Tarhan, Melek Buyuk, Kursat Rahmi Serin, Engin Ulukaya, Joanna Depciuch, Magdalena Parlinska-Wojtan, Zozan Guleken
Summary: This study used FTIR spectroscopy to detect chemical changes in the serum of CCA patients and healthy individuals. The results showed decreased TAS and increased TOS, OSI, and total protein levels in CCA patients. The FTIR spectra were able to distinguish between CCA and controls, and changes in lipids and functional groups could be used to predict CCA.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Rezvan Noroozi, Aleksandra Pisarek, Joanna Rudnicka, Michal Boron, Kamila Migacz-Gruszka, Aneta Sitek, Andrzej Ossowski, Wojciech Branicki, Magdalena Spolnicka, Ewelina Pospiech
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)