Article
Gastroenterology & Hepatology
Shi-Chuan Tang, Kai-Ling Zhang, Kong-Ying Lin, Yi-Dan Tang, Jun Fu, Wei-Ping Zhou, Jian-Xi Zhang, Jie Kong, Xiao-Lu He, Zheng-Hong Sun, Cong Luo, Hong-Zhi Liu, Yong-Ping Lai, Yong-Yi Zeng
Summary: This study demonstrated that anatomical resection decreases the risk of tumor recurrence and improves overall survival (OS) and recurrence-free survival (RFS) in patients with early-stage hepatocellular carcinoma (HCC). Anatomical resection should be adopted as long as such a surgical maneuver is feasible for initial treatment of early-stage HCC.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Surgery
J-H Zhong, B-C Xing, W-G Zhang, A. W-H Chan, C. C. N. Chong, M. Serenari, N. Peng, T. Huang, S-D Lu, Z-Y Liang, R-R Huo, Y-Y Wang, M. Cescon, T-Q Liu, L. Li, F-X Wu, L. Ma, M. Ravaioli, J. Neri, A. Cucchetti, P. J. Johnson, L-Q Li, B-D Xiang
Summary: This study investigated the safety and efficacy of repeat hepatic resection (rHR) and radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma (HCC). The results showed that rHR was associated with longer recurrence-free survival compared with RFA, while RFA had lower morbidity and shorter hospital stay.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nanping Lin, Lei Wang, Qizhen Huang, Weiping Zhou, Xiaolong Liu, Jingfeng Liu
Summary: This study developed a nomogram model to predict the overall survival of hepatocellular carcinoma patients who underwent R0 resection. The model showed good calibration and discriminatory power, and it was found that p-TACE could significantly prolong the median overall survival in high-risk patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sae-Jin Park, Jeong Hee Yoon, Dong Ho Lee, Woo Hyeon Lim, Jeong Min Lee
Summary: The study indicates that tumor stiffness measured by MRE is associated with survival in patients with single nodular hepatocellular carcinoma after hepatic resection. Tumor stiffness, tumor size, and pathological features are significant factors related to overall survival and recurrence-free survival for patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunfei Zhang, Chun Yang, Ruofan Sheng, Yongming Dai, Mengsu Zeng
Summary: Habitat imaging of HCC and peritumoral microenvironment can effectively predict the recurrence-free survival of HCC and provide sensitive biomarkers. The proportion of habitat 3 in peritumoral tissue (f(3)-P-4) is strongly associated with the risk of recurrence, and the nomogram-based predictor combining f(3)-P-4 and clinical variables shows high predictive efficacy and clinical utility.
Article
Surgery
Haili Zhang, Fei Liu, Ningyuan Wen, Bo Li, Yonggang Wei
Summary: This study found that intrahepatic recurrence was still the most common pattern after LLR for HCC, with most recurrences occurring within 2 years. There were no significant differences in recurrence patterns, timing, or treatment between LLR and OLR, with independent risk factors for recurrence including ALBI grade, postoperative alpha-fetoprotein levels, tumor size, surgical margins, and multiple tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Bin Yu, Han Liang, Qifa Ye, Yanfeng Wang
Summary: This study identified nine dysregulated and prognostic genes related to early recurrence (ER) in hepatocellular carcinoma (HCC) patients after R0 resection, and successfully constructed a prognostic index model based on these genes. The genomic-clinicopathologic nomogram integrating this model showed significantly higher predictive accuracy and clinical application value in predicting ER compared to TNM stage model.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Yi Lv, Luca Aldrighetti, Timothy M. Pawlik
Summary: The study found that setting the time point for recurrence at 8 months is beneficial for distinguishing early from late recurrence, with early recurrence patients typically having shorter survival time and post-recurrence survival, as well as less likely to receive curative treatment. Curative-intent retreatment for late recurrence patients is associated with similar overall survival compared to patients without recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Shuqi Mao, Xi Yu, Jihan Sun, Yong Yang, Yuying Shan, Jiannan Sun, Joseph Mugaanyi, Rui Fan, Shengdong Wu, Caide Lu
Summary: This study compared the predictive potential of inflammatory markers for overall survival, recurrence-free survival, and 1- and 2-year RFS in hepatocellular carcinoma patients. Nomogram prediction models were established and showed high predictive accuracy. The nomograms can serve as useful clinical tools to guide treatment approaches and prognosis judgement.
Article
Oncology
Yizhen Fu, Xia Li, Zhenyun Yang, Shaoqiang Li, Yangxun Pan, Jinbin Chen, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Li Xu, Minshan Chen, Yaojun Zhang
Summary: This study aimed to establish a risk-based post-resection follow-up strategy for hepatocellular carcinoma (HCC) patients. The results showed that this strategy could detect tumor relapse earlier and reduce the number of follow-ups without compromising on survival.
Article
Oncology
I-Cheng Lee, Hao-Jan Lei, Gar-Yang Chau, Yi-Chen Yeh, Chi-Jung Wu, Chien-Wei Su, Teh-la Huo, Yee Chao, Han-Chieh Lin, Ming-Chih Hou, Yi-Hsiang Huang
Summary: The study found that in patients with HBV-related HCC undergoing surgical resection under NUCs therapy, factors such as HBsAg levels, cirrhosis, and other markers were associated with recurrence and mortality at different time intervals. The pre-operative HBsAg level was identified as an important predictor for long-term recurrence and survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Suk Kyun Hong, Kwang-Woong Lee, Su young Hong, Sanggyun Suh, Kwangpyo Hong, Eui Soo Han, Jeong-Moo Lee, YoungRok Choi, Nam-Joon Yi, Kyung-Suk Suh
Summary: This study identified prognostic factors and recommended therapeutic strategies for patients with single large HCC and good performance status. Resection as an initial treatment should be considered, particularly for patients with low platelet count, low sodium level, and large tumor diameter. However, caution should be exercised in patients with these risk factors.
FRONTIERS IN ONCOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Licia Rivoltini, Sherrie Bhoori, Chiara Camisaschi, Laura Bergamaschi, Luca Lalli, Paola Frati, Davide Citterio, Chiara Castelli, Vincenzo Mazzaferro
Article
Gastroenterology & Hepatology
Miguel A. Martin-Serrano, Benjamin Kepecs, Miguel Torres-Martin, Emily R. Bramel, Philipp K. Haber, Elliot Merritt, Alexander Rialdi, Nesteene Joy Param, Miho Maeda, Katherine E. Lindblad, James K. Carter, Marina Barcena-Varela, Vincenzo Mazzaferro, Myron Schwartz, Silvia Affo, Robert F. Schwabe, Augusto Villanueva, Ernesto Guccione, Scott L. Friedman, Amaia Lujambio, Anna Tocheva, Josep M. Llovet, Swan N. Thung, Alexander M. Tsankov, Daniela Sia
Summary: We present a comprehensive stratification of iCCA based on the tumor microenvironment (TME). The tumor is divided into five stable STIM classes, including 35% inflamed and 65% non-inflamed profiles. The inflamed classes, immune classical and inflammatory stroma, differ in oncogenic pathways and extent of desmoplasia. Analysis of cell-cell interactions highlights cancer-associated fibroblast subtypes as potential mediators of immune evasion. Among the non-inflamed classes, the desert-like class has the lowest immune infiltration with abundant regulatory T cells, while the hepatic stem-like class is enriched in 'M2-like' macrophages and specific mutations. Comparative analysis reveals high similarity between a KRAS/p19 murine model and the inflammatory stroma class. The KRAS-SOS inhibitor sensitizes a KRAS-mutant iCCA murine model to anti-PD1 therapy. Our findings provide valuable insights into the TME of iCCA and offer potential therapeutic targets for future research.
Article
Surgery
Brian K. P. Goh, Ho-Seong Han, Kuo-Hsin Chen, Darren W. Chua, Chung-Yip Chan, Federica Cipriani, Davit L. Aghayan, Asmund A. Fretland, Jasper Sijberden, Mizelle D'Silva, Tiing Foong Siow, Yutaro Kato, Chetana Lim, Phan Phuoc Nghia, Paulo Herman, Marco Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqui Yin, Zewei Chen, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo R. Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago F. Lopez-Ben, Fabricio F. Coelho, Thomas Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni B. Levi Sandri, Mansour Saleh, Daniel Cherqui, Olivier Scatton, Olivier Soubrane, Go I. Wakabayashi, Roberto Troisi, Tan-To Cheung, Atsushi Sugioka, Mohammad Abu Hilal, David Fuks, Bjorn Edwin, Luca Aldrighetti
Summary: This study established global benchmark outcomes for laparoscopic liver resections (L-LR) by analyzing a multicenter database of 11,983 patients. Three specific procedures were selected and 15 outcome indicators were established as benchmark cutoffs. The results provide an objective assessment of performance gaps and learning curves for centers adopting L-LR.
Article
Surgery
Matteo Serenari, Jacopo Lenzi, Alessandro Cucchetti, Federica Cipriani, Matteo Donadon, Francesco Ardito, Federico Fazio, Daniele Nicolini, Maurizio Iaria, Simone Famularo, Pasquale Perri, Luca Ansaloni, Matteo Zanello, Quirino Lai, Simone Conci, Sarah Molfino, Cecilia Ferrari, Paola Germani, Mauro Zago, Maurizio Romano, Giuseppe Zimmitti, Adelmo Antonucci, Luca Fumagalli, Albert Troci, Valentina Ferraro, Riccardo Memeo, Michele Crespi, Marco Chiarelli, Giorgio A. Ercolani, Mohamed A. Hilal, Giacomo Zanus, Enrico Pinotti, Paola Tarchi, Guido Griseri, Gian Luca Baiocchi, Andrea Ruzzenente, Massimo Rossi, Elio Jovine, Marcello Maestri, Gian Luca Grazi, Fabrizio Romano, Raffaele Dalla Valle, Matteo Ravaioli, Marco Vivarelli, Alessandro Ferrero, Felice Giuliante, Guido Torzilli, Luca Aldrighetti, Matteo Cescon
Summary: This study aimed to evaluate the impact of a liver transplantation program on the outcomes of resectable hepatocellular carcinoma. The presence of a liver transplantation program was associated with decreased posthepatectomy liver failure rates and increased likelihood of salvage liver transplantation in case of tumor recurrence, which had a positive impact on postoperative survival.
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Dilmurodjon Eshmuminov, Debora J. Studer, Victor Lopez Lopez, Marcel A. Schneider, Jan Lerut, Mary Lo, Linda Sher, Thomas J. Musholt, Oana Lozan, Nabila Bouzakri, Carlo Sposito, Rosalba Miceli, Shoma Barat, David Morris, Helga Oehler, Teresa Schreckenbach, Peri Husen, Charles B. Rosen, Gregory J. Gores, Toshihiko Masui, Tan-To Cheung, Corina Kim-Fuchs, Aurel Perren, Philipp Dutkowski, Henrik Petrowsky, Espen Thiis-Evensen, Pal-Dag Line, Michal Grat, Stefano Partelli, Massimo Falconi, Lulu Tanno, Ricardo Robles-Campos, Vincenzo Mazzaferro, Pierre-Alain Clavien, Kuno Lehmann
Summary: This multicenter study compares the outcomes of liver resection (LR) and liver transplantation (LT) in patients with neuroendocrine liver metastasis (NELM). The results suggest that LT provides a survival benefit over LR, but adherence to selection criteria is important.
Article
Gastroenterology & Hepatology
Philipp K. Haber, Florian Castet, Miguel Torres-Martin, Carmen Andreu-Oller, Marc Puigvehi, Maeda Miho, Pompilia Radu, Jean-Francois Dufour, Chris Verslype, Carolin Zimpel, Jens U. Marquardt, Peter R. Galle, Arndt Vogel, Melanie Bathon, Tim Meyer, Ismail Labgaa, Antonia Digklia, Lewis R. Roberts, Mohamed A. Mohamed Ali, Beatriz Minguez, Davide Citterio, Vincenzo Mazzaferro, Fabian Finkelmeier, Joerg Trojan, Burcin Ozdirik, Tobias Mueller, Moritz Schmelzle, Anthony Bejjani, Max W. Sung, Myron E. Schwartz, Richard S. Finn, Swan Thung, Augusto Villanueva, Daniela Sia, Josep M. Llovet
Summary: This study analyzed tumor samples from patients with advanced hepatocellular carcinoma (aHCC) treated with anti-PD1 and identified interferon signaling and major histocompatibility complex-related genes as key molecular features of HCCs responding to anti-PD1. The researchers developed an 11-gene signature that can predict treatment response and survival in frontline aHCC patients.
Letter
Gastroenterology & Hepatology
Carlo Sposito, Alessandro Cucchetti, Vincenzo Mazzaferro
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro, Carlo Sposito, Christian Oberkofler, Ellie Brandon, Benjamin Samstein, Cristiano Guidetti, Alexandros Papageorgiou, Samuele Frassoni, Vincenzo Bagnardi, Pierre-Alain Clavien, Davide Citterio, Tomoaki Kato, Henrik Petrowsky, Karim J. Halazun, Vincenzo Mazzaferro, Robotic HPB Study Grp
Summary: This study examined the short-term and long-term outcomes of robotic liver resection (RLR) for hepatocellular carcinoma (HCC) in Western high-volume centers. The study found that RLR had shorter hospital stays and lower incidence of postoperative liver failure compared to open liver resection (OLR). Furthermore, there were no significant differences in tumor recurrence and overall survival rates between the two groups.
Review
Oncology
Marianna Maspero, Carlo Sposito, Matteo Virdis, Davide Citterio, Filippo Pietrantonio, Sherrie Bhoori, Filiberto Belli, Vincenzo Mazzaferro
Summary: Over 40% of colorectal cancer patients develop liver metastases, with poor prognosis for those with unresectable disease. Liver transplantation has shown improved survival in selected patients with unresectable colorectal liver metastases. This article provides an overview of the current status, issues, and future directions of liver transplantation for colorectal liver metastases.
Article
Biochemistry & Molecular Biology
Cristina Morsiani, Salvatore Collura, Federica Sevini, Erika Ciurca, Valentina Rosa Bertuzzo, Claudio Franceschi, Gian Luca Grazi, Matteo Cescon, Miriam Capri
Summary: The study aimed to evaluate the changes in circulating microRNA (c-miR) in the blood of liver transplant recipients before and after transplantation, and to correlate their levels with gold standard biomarkers and outcomes such as rejection or complications. The results showed that c-miR changes were associated with follow-up time, and miR-122-5p, miR-92a-3p, and miR-18a-5p exhibited the same trend after transplantation, with an increase in their levels in patients with complications. Compared to changes in standard haemato-biochemical parameters, the importance of c-miRs as potential noninvasive biomarkers for monitoring patient outcomes was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Article
Surgery
Anne-Marleen van Keulen, Stefan Buettner, Joris Erdmann, Johann Pratschke, Francesca Ratti, William R. Jarnagin, Andreas A. Schnitzbauer, Hauke Lang, Andrea Ruzzenente, Silvio Nadalin, Matteo Cescon, Baki Topal, Pim B. Olthof, Bas Groot Koerkamp
Summary: Two preoperative prognostic models were created to predict 90-day mortality and survival after major liver resection for perihilar cholangiocarcinoma. The results showed that 17.6% of patients were suitable for surgical treatment, 26.8% of patients were not suitable for surgical treatment, and 66.2% of patients were in the intermediate risk group. These prognostic models can help identify patients with resectable perihilar cholangiocarcinoma who are unlikely to benefit from surgical resection.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Andrea Laurenzi, Giovanni Brandi, Federica Greco, Enrico Prosperi, Andrea Palloni, Matteo Serenari, Giorgio Frega, Matteo Ravaioli, Alessandro Rizzo, Matteo Cescon
Summary: Repeated surgical resection for recurrent cholangiocarinoma is a feasible treatment option that can improve survival in patients. This study evaluated the long-term outcomes of patients who underwent repeated resection for recurrent CCA and found that it can lead to good postoperative results and increased survival.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Amedeo Bianchini, Cristiana Laici, Martina Bordini, Matteo Bianchin, Catalin Iustin Ioan Silvas, Matteo Cescon, Matteo Ravaioli, Giovanni Vitale, Antonio Siniscalchi
Summary: This article mainly introduces the application of TEE in liver transplantation, especially in the case of using VVB, as an important tool for guiding treatment. TEE has multiple potential uses in guiding catheterization and optimal cannula positioning, managing Patent Foramen Ovale, assisting in anticoagulation therapy, and evaluating bypass efficiency and correcting hypovolemia.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)