期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 9, 页码 2119-2123出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.03.079
关键词
2,3-Diarylindole; Apoptosis; Autophagy; Lung cancer
资金
- Kasetsart University Research and Development Institute (KURDI)
- Faculty of Science, Kasetsart University
- Chulabhorn Research Institute
- Center of Excellence for Innovation in Chemistry (PERCH-CIC), the Office of the Higher Education Commission, Ministry of Education
A series of 2,3-diarylindoles were synthesized via the Larock heteroannulation, and evaluated for their anticancer activity against A549 lung cancer cells. The most potent compound, PCNT13 with IC50 = 5.17 mu M, caused the induction of two modes of programmed cell death, apoptosis and autophagy. (C) 2016 Elsevier Ltd. All rights reserved.
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