Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes

Morphologic determinant of tight junctions revealed by claudin-3 structures

(2019) Shun Nakamura et al.   Nature Communications

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8

(2019) Beatriz Herguedas et al.   SCIENCE

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

(2019) G. Brent Dawe et al.   NEURON

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

(2019) Yan Zhao et al.   SCIENCE

Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors

(2018) Edward C. Twomey et al.   NEURON

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

(2018) Jelena Baranovic et al.   eLife

Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation

(2017) Patricia M.G.E. Brown et al.   JOURNAL OF GENERAL PHYSIOLOGY

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin

(2017) Anat Ben-Yaacov et al.   NEURON

Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes

(2017) Edward C. Twomey et al.   NEURON

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

(2017) Aline Brechet et al.   Nature Communications

Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

(2017) Irene Riva et al.   eLife

Structural biology of glutamate receptor ion channel complexes

(2016) Mark L Mayer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM

(2016) Yan Zhao et al.   NATURE

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

(2016) Akihiko S Kato et al.   NATURE MEDICINE

Synaptic AMPA receptor composition in development, plasticity and disease

(2016) Jeremy M. Henley et al.   NATURE REVIEWS NEUROSCIENCE

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes

(2016) G. Brent Dawe et al.   NEURON

Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy

(2016) E. C. Twomey et al.   SCIENCE

Superactivation of AMPA receptors by auxiliary proteins

(2016) Anna L. Carbone et al.   Nature Communications

Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission

(2016) Nadine Erlenhardt et al.   Cell Reports

Stargazin Modulation of AMPA Receptors

(2016) Sana A. Shaikh et al.   Cell Reports

Glutamate Synapses in Human Cognitive Disorders

(2015) Lenora Volk et al.   Annual Review of Neuroscience

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

(2015) Y. Saitoh et al.   SCIENCE

Stargazin promotes closure of the AMPA receptor ligand-binding domain

(2014) David M. MacLean et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modulation of non-NMDA receptor gating by auxiliary subunits

(2014) James R. Howe   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate receptor pores

(2014) James E. Huettner   JOURNAL OF PHYSIOLOGY-LONDON

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

(2014) H. Suzuki et al.   SCIENCE

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

(2014) Thomas E. Chater et al.   Frontiers in Cellular Neuroscience

Structure and gating of tetrameric glutamate receptors

(2013) Alexander I. Sobolevsky   JOURNAL OF PHYSIOLOGY-LONDON

AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting

(2013) P. Hastie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Insights from Glutamate Receptor Ion Channel Structures

(2012) Janesh Kumar et al.   Annual Review of Physiology

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

(2012) Natalie F. Shanks et al.   Cell Reports

Probing TARP Modulation of AMPA Receptor Conductance with Polyamine Toxins

(2011) A. C. Jackson et al.   JOURNAL OF NEUROSCIENCE

Cornichon-2 Modulates AMPA Receptor-Transmembrane AMPA Receptor Regulatory Protein Assembly to Dictate Gating and Pharmacology

(2011) M. B. Gill et al.   JOURNAL OF NEUROSCIENCE

Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex

(2010) K. S. Kim et al.   JOURNAL OF NEUROSCIENCE

SynDIG1: An Activity-Regulated, AMPA- Receptor-Interacting Transmembrane Protein that Regulates Excitatory Synapse Development

(2010) Evgenia Kalashnikova et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus

(2010) J. von Engelhardt et al.   SCIENCE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

The Stoichiometry of AMPA Receptors and TARPs Varies by Neuronal Cell Type

(2009) Yun Shi et al.   NEURON

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

(2009) J. Schwenk et al.   SCIENCE

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets

Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits

(2008) Aaron D. Milstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES