Article
Integrative & Complementary Medicine
Xiaoying Cui, Lili Lin, Xiaoling Sun, Lin Wang, Rong Shen
Summary: The study aimed to explore the pharmacological effects of curcumin on oxidative stress and inflammatory response in renal dysfunction induced by renal ischemia/reperfusion. Results showed that curcumin pretreatment significantly increased antioxidant levels and decreased oxidative stress markers in tissues, leading to improved renal function in the rat model of ischemia-reperfusion.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Minglei Bi, Danyi Li, Jin Zhang
Summary: Ischemia-reperfusion injury (IRI) is a common pathological process after organ transplantations, and the damage caused by IRI is often ignored. Curcumin, a polyphenol compound, has been shown to have protective effects against IRI through its anti-oxidative stress, anti-inflammation and anti-apoptosis properties. However, there are still controversies about the underlying mechanisms of curcumin's effects on IRI. This review aims to summarize the protective role of curcumin against IRI and clarify its underlying mechanisms, providing a novel idea for the therapy of IRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Shijian Feng, Ying Qu, Bingyang Chu, Xiaoting Chen, Ziyan Yang, Peiwen Li, Peiyu Wang, Qiyu He, Yushi He, Tao Lin, Zhongli Huang, Zhiyong Qian
Summary: Kidney ischemia reperfusion injury (IRI) is a common and inevitable pathological condition, especially during transplantation. Current clinical treatment options are inadequate. However, a study has shown that gold-platinum nanoparticles can scavenge excessive reactive oxygen species and alleviate kidney IRI. These nanoparticles possess anti-oxidative properties and demonstrate excellent cell protective capability.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.
Article
Medicine, Research & Experimental
Li Luo, Guangchao Zang, Boyan Liu, Xian Qin, Yuchan Zhang, Yidan Chen, Haijun Zhang, Wei Wu, Guixue Wang
Summary: The biomimetic smart nanotherapeutics developed in this study utilize targeted technology to show significant therapeutic effects and biosafety in animal models, achieving treatment of cerebral ischemia-reperfusion injury by activating corresponding receptors and chemokines.
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Malihe Mohamadian, Negin Parsamanesh, Hossein Chiti, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Ischemia/reperfusion injury refers to tissue damage caused by reperfusion after ischemic injury. Therapeutic outcomes for this condition still need improvement. Curcumin, derived from turmeric, has been found to have strong anti-inflammatory and antioxidant properties, and it plays a protective role in various organs against I/R injury.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell & Tissue Engineering
Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye, Qiang Su
Summary: The study found that curcumin-hydrogel can reduce cardiomyocyte apoptosis, reactive oxygen species formation, promote autophagy, reduce mitochondrial damage, restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate the JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Nutrition & Dietetics
Douglas Ikedo Machado, Eloiza de Oliveira Silva, Sara Ventura, Maria de Fatima Fernandes Vattimo
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Article
Cell Biology
Jun Xu, Sijie Li, Alexandra Wehbe, Xunming Ji, Yong Yang, Yu Yang, Linhui Qin, Feng-Yong Liu, Yuchuan Ding, Changhong Ren
Summary: Abdominal aortic occlusion (AAO) does not induce cell necrosis or apoptosis in cardiac or neurologic tissue, but it can cause inflammation in the serum, brain, and heart.
MEDIATORS OF INFLAMMATION
(2023)
Article
Chemistry, Multidisciplinary
Xinhai Mo, Huijing Xiang, Lu Wei, Lianghua Xia, Xiaoying Chen, Yu Chen, Bo Zhang
Summary: Using self-assembly synthesis, allomelanin nanoparticles (AMNPs) show potential in treating myocardial I/R injury by providing antioxidative and anti-inflammatory effects, with targeted therapy at damaged cardiac sites.
Article
Multidisciplinary Sciences
Ying Wang, Yong Wu, Shu Peng
Summary: This study aimed to investigate the effects and mechanisms of resveratrol (RSV) in uterine ischemia reperfusion (I/R)-induced injury. The results showed that RSV treatment increased antioxidant capacity, suppressed uterine oxidative injury, decreased pro-inflammatory cytokine levels, increased anti-inflammatory cytokine levels, and activated the PI3K-AKT pathway, suggesting that RSV may play a protective role in I/R-induced uterus injury.
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Wenfei He, Jingsong Wang, Qiling Jin, Jiafeng Zhang, Yugang Liu, Zewu Jin, Hua Wang, Linya Hu, Lu Zhu, Mengya Shen, Lili Huang, Shengwei Huang, Wulan Li, Qichuan Zhuge, Jianzhang Wu
Summary: This study designed a novel class of antioxidants sAc analogs to treat cerebral ischemia reperfusion injury (CIRI) by reducing toxicity and improving stability. The optimally active compound sAc15 effectively protected cells from oxidative stress injury and showed good protection against CIRI in a mouse model.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Nazmiye B. Yapici, Srinivas Mandalapu, K. Michael Gibson, Lanrong Bi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Chemistry, Medicinal
Wei Bi, Yue Bi, Xiang Gao, Xin Yan, Yanrong Zhang, Ping Xue, Catherine E. Bammert, Thomas D. Legalley, K. Michael Gibson, Lanrong Bi, Jia-Xiang Wang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Biochemistry & Molecular Biology
Xiangdong Liu, Xiang Gao, Wentao Zhang, Tianyi Zhu, Wei Bi, Yanrong Zhang
Article
Chemistry, Medicinal
Wei Bi, Jianhui Cai, Ping Xue, Yanrong Zhang, Sanguang Liu, Xiang Gao, Meng Li, Zhibo Wang, Michele Baudy-Floc'h, Sarah A. Green, Lanrong Bi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2008)
Article
Chemistry, Medicinal
Wei Bi, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Michele Baudy-Floc'h, Nathaniel Ngerebara, K. Michael Gibson, Lanrong Bi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Chemistry, Medicinal
Wei Bi, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Michele Baudy-Floc'h, Nathaniel Ngerebara, Xiaoxu Li, K. Michael Gibson, Lanrong Bi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Pharmacology & Pharmacy
Wei Bi, Fengan Wang, Yue Bi, Tianyang Wang, Ping Xue, Yanrong Zhang, Xiang Gao, Sanguang Liu, Zhibo Wang, Meng Li, Michele Baudy-Floc'h, Sara C. Robinson, Nathaniel Ngerebara, Lanrong Bi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2009)
Article
Chemistry, Medicinal
Wei Bi, Xiaoxu Li, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Yasuhiro Itagaki, Lanrong Bi
JOURNAL OF MEDICINAL CHEMISTRY
(2012)
Article
Chemistry, Multidisciplinary
Nazmiye B. Yapici, Xiang Gao, Xin Yan, Shanshan Hou, Steffen Jockusch, Lillian Lesniak, K. Michael Gibson, Lanrong Bi
Summary: The pH differences in organelles have functional implications and proper distribution of H+ ions across membranes is crucial for cellular events. Mitochondria and lysosomes are closely related, and a single fluorescent probe targeting both organelles can facilitate the understanding of their crosstalk.
Article
Biochemistry & Molecular Biology
Xiang Gao, Yue Bi, Kui Chi, Yang Liu, Tao Yuan, Xueyan Li, Wei Bi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Wei Bi, Yue Bi, Xiang Gao, Pengfei Li, Shanshan Hou, Yanrong Zhang, Cathy Bammert, Steffen Jockusch, Thomas D. Legalley, K. Michael Gibson, Lanrong Bi
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)
Article
Cell Biology
Yue Zhang, Xiang Gao, Shuanggang Chen, Min Zhao, Jing Chen, Rui Liu, Shengyang Cheng, Mengyuan Qi, Shuo Wang, Wei Liu
CELLULAR SIGNALLING
(2017)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
