Article
Engineering, Environmental
Purna K. Boruah, Gitashree Darabdhara, Priyakshree Borthakur, Benjamin Le Ouay, Manash R. Das
Summary: This article presents a novel composite material consisting of Fe3O4 quantum dots immobilized on polydopamine-functionalized graphene, which acts as a powerful platform for detecting Cr(VI) ions and reducing them to non-toxic ions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu
Summary: Fluorescent carbon dots (CDs) derived from Weissella sp. Kl-3, known as CDs-Ws, exhibit strong fluorescence, excellent biocompatibility, and low cytotoxicity. CDs-Ws can selectively label and differentiate cells, as well as function as a fluorescence nanosensor for detecting Cr(VI) and VB12 with high sensitivity and detection limits. The CDs-Ws show great potential in bioimaging and detection of specific substances.
Article
Chemistry, Physical
Hongwei Zhao, Rui Li, Yinxiu Wang, Zhonghua Zhao, Shaomin Shuang
Summary: In this study, red-emitting nitrogen-doped carbon dots (N-CDs) were synthesized using p-phenylenediamine and poly-ethylene glycol 20,000 as precursors. The N-CDs exhibited uniform spherical shape with an average particle size of 2.36 nm. These N-CDs displayed excitation-independent fluorescence with optimal excitation and maximum emission wavelengths at 487 and 628 nm, respectively. The prepared N-CDs demonstrated rapid and highly selective recognition of Cu2+ with a detection limit of 45.87 μM, and the addition of Cu2+ caused a visible color change of the N-CDs solution. Furthermore, a smartphone-based platform was developed for real-time detection of Cu2+ in the linear range of 20-140 μM, with a detection limit of 35.83 μM.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Mingyan Jia, Lulin Peng, Maohua Yang, Huangzhao Wei, Mei Zhang, Yu Wang
Summary: This study demonstrates the unique fluorescent ratiometricity of conventional boron-nitrogen co-doped carbon dots (BNCDs) in detecting Cr (VI), providing a new way for rapid determination of analytes. The versatile sensing capability of BNCDs highlights the great potential of carbon-based materials for developing ratiometric sensing platforms.
Article
Chemistry, Analytical
Yuecheng Zhang, Chengjia Li, Lingbo Sun, Jie Zhang, Xiaojun Yang, Hongyan Ma
Summary: A simple and sensitive ratiometric sensor based on the coordination between Cr(VI) and carbon dots (CDs) was developed for accurate detection of Cr(VI) concentration. The study demonstrated that the dual-amino groups play a critical role in the coordination mechanism, and the method showed promising results in real water sample analysis.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
YingTe Wang, RongRong Wu, YuanYuan Zhang, SiRong Cheng, Yong Zhang
Summary: N-doped carbon dots (N-CDs) with green fluorescence were synthesized by hydrothermal reaction using o-aminophenol and ethylenediamine as carbon and nitrogen sources, and they exhibited a quantum yield of 38.4%. The N-CDs were characterized by FT-IR, XPS, UV-vis, and fluorescence spectroscopy, confirming their excellent fluorescence properties and stability. Furthermore, the N-CDs were utilized as a sensor for Ag+ detection through static quenching effect, with a linear range of 30-210 μmol/L and a detection limit of 4.7 μmol/L. The N-CDs also showed potential applications in bioimaging for Ag+ sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Meng Yang, Hui Jin, Rijun Gui
Summary: In this study, a metal-doping strategy was proposed to construct metal-doped borophene and boron quantum dots (BQDs). Ag+ was identified as the optimal metal ion for preparing Ag+-doped borophene derived BQDs (Ag-BQDs) based on theoretical calculations. The doping of Ag+ enhanced the stability and fluorescence properties of borophene. Experimental results demonstrated the excellent performance of Ag-BQDs in various applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemical Research Methods
Jierong Xie, Zhaofeng Wu, Jun Sun, Changwu Lv, Qihua Sun
Summary: Green and economical self-doped nitrogen-containing fluorescent carbon quantum dots (N-CQDs) were synthesized using a one-pot hydrothermal treatment method. The optical and structural properties of N-CQDs were investigated, and their sensitivity and selectivity to Cr (VI) were demonstrated. The study also explored the quenching mechanism of N-CQDs by Cr (VI).
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaoning Li, Meng Li, Quanyu Shi, Hongmin Guo, Lidong Wang, Xiaolin Guo, Zhijun Chen, Jonathan L. Sessler, Huining Xiao, Tony D. James
Summary: The study involves the creation of a multifunctional CPC aerogel with efficient Cr(VI) adsorption capacity, meeting industrial water safety standards. It can be used for solar thermoelectric power generation and seawater desalination.
Article
Chemistry, Multidisciplinary
Shipeng Wang, Haoran Zhao, Jinliang Yang, Yahui Dong, Shaozheng Guo, Qian Cheng, Yu Li, Shouxin Liu
Summary: Multicolor fluorescent biomass carbon dots (BCDs) were prepared from spinach using an ecofriendly solvothermal method. The luminescence colors of the obtained BCDs can be tuned by changing the solvents, which affects the carbonization process of polysaccharides and chlorophyll in spinach. The blue BCDs show excellent sensitivity and selectivity towards Cr(VI), making them a promising candidate for ion detection.
Article
Chemistry, Multidisciplinary
Xu Gao, Jing Qin, Jingyi Liu, Zhen Yang, Guoliang Zhang, Juan Hou
Summary: Bioinspired carbon dots with excellent biocompatibility were prepared from egg white, exhibiting bright blue fluorescence and sensitive response to tetracycline. They have potential applications in biochemical sensing and biomedical imaging.
Article
Chemistry, Multidisciplinary
Xu Gao, Jing Qin, Jingyi Liu, Zhen Yang, Guoliang Zhang, Juan Hou
Summary: Bioinspired carbon dots with excellent biocompatibility were synthesized from egg white through a simple hydrothermal method. The obtained carbon dots displayed bright blue fluorescence, optical stability, and sensitive response to tetracycline. The detection platform has been successfully applied in the determination of tetracycline in milk samples with good performance.
Article
Engineering, Environmental
J. Mejia Avila, M. Rangel Ayala, Y. Kumar, E. Perez-Tijerina, Mitchel A. R. Robles, V Agarwal
Summary: Sustainable, scalable, and green carbon dots derived from avocado seeds were used as fluorescent nanoprobes for the detection of heavy metal ions. The carbonization temperature affected the size, crystallinity, and sensitivity of the carbon dots towards Cu2+ and Cr6+ ions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Juan Yue, Qian Mei, Panyong Wang, Peng Miao, Wen-Fei Dong, Li Li
Summary: The yellow fluorescent carbon dots (CDs) for detecting GSSG through a fluorescence off-on process show linear correlation with GSSG concentration and a detection limit of 0.18mu M. Additionally, the CDs can also be used for fluorescence imaging in living cells and zebrafish.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Yang Chen, Huijing Cui, Mao Wang, Xudong Yang, Shujie Pang
Summary: A fluorescent probe based on carbon dots (CDs) with low cost, low environmental impact, high stability, and good water solubility was developed for the detection of Cr(VI). Unlike most previous sensors, this probe enhances fluorescence rather than quenching it, and has a very low detection limit.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biochemistry & Molecular Biology
Saima Nusrat, Nida Zaidi, Masihuz Zaman, Sehbanul Islam, Mohammad Rehan Ajmal, Mohammad Khursheed Siddiqi, Manas Kumar Santra, Rizwan Hasan Khan
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Biochemistry & Molecular Biology
Tracy Augustine, Priyanka Chaudhary, Kailash Gupta, Sehbanul Islam, Payel Ghosh, Manas Kumar Santra, Debashis Mitra
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Oncology
Balija Sivakrishna, Sehbanul Islam, Amarendra Panda, Maddi Saranya, Manas K. Santra, Shantanu Pal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2018)
Article
Oncology
Debasish Paul, Sehbanul Islam, Rajesh Kumar Manne, U. S. Dinesh, Sunil K. Malonia, Biswanath Maity, Ramanamurthy Boppana, Srikanth Rapole, Praveen Kumar Shetty, Manas Kumar Santra
JOURNAL OF PATHOLOGY
(2019)
Article
Chemistry, Medicinal
Balija Sivakrishna, Sehbanul Islam, Manas K. Santra, Shantanu Pal
DRUG DEVELOPMENT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Parul Dutta, Sehbanul Islam, Srinadh Choppara, Pallabi Sengupta, Anil Kumar, Avinash Kumar, Mohan R. Wani, Subhrangsu Chatterjee, Manas Kumar Santra
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Oncology
Venkatesh Chanukuppa, Debasish Paul, Khushman Taunk, Tathagata Chatterjee, Sanjeevan Sharma, Amey Shirolkar, Sehbanul Islam, Manas K. Santra, Srikanth Rapole
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sehbanul Islam, Parul Dutta, Osheen Sahay, Manas Kumar Santra
Summary: Research suggests that beta-TrCP1 and beta-TrCP2 play roles during genotoxic stress, with beta-TrCP1 showing increased expression levels and beta-TrCP2 showing decreased levels, achieved through ATM kinase activation and phosphorylation of beta-TrCP1. Phosphorylated beta-TrCP1 promotes p53 activation and DNA damage repair by degrading beta-TrCP2 and MDM2.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sehbanul Islam, Parul Dutta, Kriti Chopra, Srikanth Rapole, Radha Chauhan, Manas Kumar Santra
Summary: The expression levels of F-box protein beta-TrCP1 oscillate during cell cycle progression and are regulated by another F-box protein FBXW8. FBXW8 directs the proteasomal degradation of beta-TrCP1 in a MAPK pathway-dependent manner, which is crucial for cell cycle transition and DNA damage-free progression of the cell cycle.
Article
Biochemistry & Molecular Biology
Sehbanul Islam, Parul Dutta, Kriti Chopra, Osheen Sahay, Srikanth Rapole, Radha Chauhan, Manas Kumar Santra
Summary: The study reveals that Cullin1 and Cullin7 synergistically increase their binding to FBXW8, essential for the formation of the Cullin1SKP1-FBXW8-Cullin7 functional ubiquitin ligase complex. Computational, mutational, and biochemical analysis showed that Cullin1 binds to the N-terminus of FBXW8 through SKP1, while Cullin7 associates with the C-terminus of FBXW8 in a cooperative manner. The Cullin1-SKP1-FBXW8-Cullin7 complex plays a crucial role in maintaining the basal level expression of 8-TrCP1 and promoting cell migration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Sehbanul Islam, Parul Dutta, Osheen Sahay, Kesavaperumal Gopalakrishnan, Sushrita Roy Muhury, Parinitha Parameshwar, Praveenkumar Shetty, Manas Kumar Santra
Summary: The oncogene c-Myc suppresses the expression of FBXO31 in ovarian cancer, impairing its tumor-suppressive functions. In contrast, FBXO31 degrades c-Myc through the proteasome pathway, inhibiting ovarian cancer growth. The c-Myc-FBXO31 axis shows promise as a target for developing better cancer therapies.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Yashika Agrawal, Tanisha Sharma, Sehbanul Islam, Kaustubh S. Nadkarni, Manas Kumar Santra
Summary: This study reveals the role of FBXO41 in cancer progression, demonstrating its ability to suppress cancer cell proliferation and tumor growth by inducing autophagic cell death through an alternative pathway. It establishes a new FBXO41-SKP2-p21 axis for induction of autophagic cell death to prevent cancer growth, providing a potential avenue for the development of promising cancer therapeutics.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Cell Biology
Ganesh Kumar Barik, Osheen Sahay, Anindya Mukhopadhyay, Rajesh Kumar Manne, Sehbanul Islam, Anup Roy, Somsubhra Nath, Manas Kumar Santra
Summary: This study reveals that FBXW2 functions as a tumor suppressor and AKT kinase plays a key role in the oncogenic function of Moesin in breast cancer. AKT phosphorylates Moesin at a specific site, preventing its degradation by FBXW2 and thus contributing to the role of Moesin in breast cancer progression. Additionally, Moesin also acts as an upstream regulator of the oncogene SKP2, stabilizing it by preventing its degradation.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Reyaz ur Rasool, Caitlin M. O'Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E. Frohner, Qu Deng, Erick Mitchell-Velasquez, Jaya Sangodkar, Aqila Ahmed, Sarah Linauer, Ingrid Mudrak, Jessica Rainey, Kaitlin P. Zawacki, Tahra K. Suhan, Catherine G. Callahan, Ryan Rebernick, Ramakrishnan Natesan, Javed Siddiqui, Guido Sauter, Dafydd Thomas, Shaomeng Wang, Derek J. Taylor, Ronald Simon, Marcin Cieslik, Arul M. Chinnaiyan, Luca Busino, Egon Ogris, Goutham Narla, Irfan A. Asangani
Summary: Loss of tumor suppressive activity of PP2A is associated with cancer, and the underlying mechanisms are unclear. LCMT1, which methylates the C subunit of PP2A, acts as a suppressor of AR addicted PCa. Decreased methyl-PP2A-C levels in prostate tumors are associated with biochemical recurrence and metastasis.
NATURE COMMUNICATIONS
(2023)