Article
Chemistry, Multidisciplinary
B. Shriya Saikia, Paran J. Borpatra, Iftakur Rahman, Mohit L. Deb, Pranjal K. Baruah
Summary: This study reports a catalyst-free method for the sulfenylation of 6-aminouracils using visible light as the energy source. It demonstrates the formation of new C-S bonds at the 5-position of 6-aminouracils under irradiation, resulting in the synthesis of sulfenylated products in good yields. The method shows good tolerance towards various 6-aminouracil substrates and can also be applied for the synthesis of disulfide compounds.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Ronald J. Sokol, Emmanuel M. Gonzales, Binita M. Kamath, Alastair Baker, Pamela Vig, Douglas B. Mogul, Will Garner, Bettina E. Hansen, Emmanuel Jacquemin, Richard J. Thompson
Summary: Improvement in pruritus by 48 weeks, and lower W48 bilirubin and serum bile acid levels were associated with fewer events in patients with Alagille syndrome (ALGS) treated with maralixibat (MRX).
Article
Biochemistry & Molecular Biology
Mariana Silva Almeida, Shohei Shibagaki, Satoko Tahara-Hanaoka, Shiro Shibayama, Akira Shibuya
Summary: The study found that Allergin-1 is highly expressed in dermal dendritic cells and mice deficient in Allergin-1 exhibited exacerbated symptoms in type 2 contact hypersensitivity, while showing no significant impact on type 1 reaction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Dermatology
Nermin Ozlen, Deniz Ercetin, Melike Sapmaz-Metin, Ozgur Gunduz
Summary: This study investigated the antipruritic and anti-inflammatory effects of hydrogen sulfide (H2S) in allergic contact dermatitis (ACD). The results showed that sodium sulfide (Na2S) can reduce ear thickness, inhibit the infiltration and proliferation of CD4(+) T lymphocytes, and decrease IL-2 synthesis.
DERMATOLOGICA SINICA
(2023)
Article
Environmental Sciences
Dina Tucovic, Jelena Kulas, Ivana Mirkov, Dusanka Popovic, Lidija Zolotarevski, Marta Despotovic, Milena Kataranovski, Aleksandra Popov Aleksandrov
Summary: The study found that oral cadmium intake intensifies the skin response to sensitizing chemicals, leading to inflammation and injury.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eri Shimura, Hajime Suto, Takafumi Numata, Sachiko Yamaguchi, Kazutoshi Harada, Ko Okumura, Katsuko Sudo, Masashi Ikutani, Susumu Nakae
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease with unclear pathogenesis. The study found that the expression of interleukin-25 (IL-25) was significantly increased in a mouse model of oxazolone-induced chronic contact hypersensitivity (CHS), which is similar to human AD. IL-25 plays a crucial role in the development of chronic CHS, although it depends on the genetic background of the mice to some extent.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Hiroshi Kuwata, Yoshihito Nakatani, Chieko Yokoyama, Shuntaro Hara
Summary: The study investigated the roles of mPGES-1 and PGIS in cutaneous immune responses using a contact hypersensitivity (CHS) model. The results indicated that these PG terminal synthases play critical roles in acquired cutaneous immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xin Cheng, Bowen Yang, Jinfang Zheng, Hongyu Wei, Xuehuan Feng, Yanbin Yin
Summary: The isolation of a Cd-resistant strain CX 2-6 from contaminated farmland sheds light on the genetic response of Enterococcus faecium to heavy metal stress, providing insights into the metabolic reprogramming under Cd stress.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biology
Dominik Nemeth, Gyorgyi Ponyai
Summary: The clinical characteristics of contact hypersensitivity in the elderly patient population were analyzed in this study. Contact dermatitis was the most common diagnosis, followed by psoriasis. The most common contact allergens identified were preservatives, balsam of Peru, and nickel. It is important to conduct patch testing to verify contact hypersensitivity in older individuals, even for conditions such as contact dermatitis, venous stasis dermatitis, rosacea, and atopic dermatitis.
Editorial Material
Dermatology
Sarah Fleming, Ian R. White, Louise Cunningham, Karen Eustace
Summary: Hypersensitivity reactions to corticosteroids present a clinical paradox due to their anti-inflammatory and immunomodulatory effects. This case report discusses a patient with positive patch test results to the corticosteroid series.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Puja Upadhaya, Felipe F. Lamenza, Suvekshya Shrestha, Peyton Roth, Sushmitha Jagadeesha, Hasan Pracha, Natalie A. Horn, Steve Oghumu
Summary: Berries and their active constituents have potential therapeutic effects in mitigating contact hypersensitivity (CHS). This study demonstrated that black raspberry extract (BRB-E) and certain natural compounds found in berries can inhibit the activation of dendritic cells (DCs) and reduce the production of proinflammatory cytokines, suggesting potential novel approaches for alleviating CHS.
Article
Medicine, Research & Experimental
Sergio Lopez-Estevez, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: Sigma-1 receptors play an important role in intestinal inflammation-associated referred hyperalgesia, with knockout mice showing significant attenuation in inflammation associated hypersensitivity. The absence of sigma(1)Rs had little impact on colitis generation and progression, but did show reduction in edema and down-regulation of iNOS gene expression during the chronic phase.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Eva Sanchez Armengol, Aletta Blanka Kerezsi, Flavia Laffleur
Summary: Textile production is one of the most polluting industries worldwide, with chemical waste products posing risks to human health. Medical textiles, such as sutures and dressings, are being developed to aid in patient diagnosis, therapy, and recovery. The future of smart textiles in the medical field holds promising advancements for patient care and treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Ankit M. Gandhi, Megan D. Shah, Lindsay E. Donohue, Heather L. Cox, Joshua C. Eby
Summary: The study found that switching to cefazolin treatment in patients with suspected non-IgE-mediated HSR to nafcillin was safe, with 89% of patients completing cefazolin therapy and 10% not tolerating it. Among those who did not tolerate, 3 patients experienced unrelated reactions while 5 experienced the same reaction as attributed to nafcillin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)