期刊
出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03601234.2019.1675406
关键词
Triazole fungicides; triticonazole; chiral; liquid chromatography?tandem mass spectrometry
资金
- National Key R&D Program of China [2017YFE0102200, 2017YFC0908600]
The purpose of this study was to study the excretion stereoselectivity of triticonazole enantiomers in rat urine and faeces. Six male Sprague-Dawley (SD) rats were administrated 50?mg/kg rac-triticonazole. Rats urine and faeces were separately and quantitatively collected at the following intervals: 0?3, 3?6, 6?9, 9?12, 12?24, 24?36 and 36?48?h. The faeces samples were homogenized in an aqueous solution containing 0.2% DMSO at the ratio of 1?g: 40?mL. An aliquot of 100??L rats urine or faeces homogenate was spiked and mixed with 6.0??L of 1.00??g/mL flusilazole as an internal standard. The triticonazole enantiomers in urine and faeces were determined by using an HPLC/MS?MS after samples preparation. The excreted amounts of enantiomers in the urine showed a significant difference (P?
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