Article
Medicine, Research & Experimental
Martin Porubsky, Sona Gurska, Jarmila Stankova, Marian Hajduch, Petr Dzubak, Jan Hlavac
Summary: The study introduces two concepts of drug delivery using small-molecule drug conjugates for specific targeting and drug release monitoring via ratiometric fluorescence. The results demonstrate efficient thiol-mediated cleavage of the fluorescent reporter and subsequent drug liberation in a test tube. Furthermore, the conjugate with c(RGDfK) is able to penetrate cells and release drugs, which can be monitored inside the cells.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Xiaobei Huang, Ning Mu, Yuanfu Ding, Hou Wang Lam, Ludan Yue, Cheng Gao, Tunan Chen, Zhen Yuan, Ruibing Wang
Summary: In this study, an innovative nanomedicine for combined chemo-photodynamic therapy of melanoma was developed, which improved cellular uptake through targeted drug delivery and the charge-reversal phenomenon.
ACTA BIOMATERIALIA
(2022)
Article
Biophysics
Hongjie Xiong, Jing Ye, Maonan Wang, Yihan Wang, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: This article introduces a new strategy for specific tumor imaging and photodynamic therapy using in-situ bio-synthesized gold nanocrystals combined with mitochondria-targeted aptamer-Pyro conjugates. In vitro and in vivo studies demonstrate that this approach can effectively inhibit tumor growth and enhance the efficacy of photodynamic therapy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Ruchika Goyal, Gaurav Jerath, R. Akhil, Aneesh Chandrasekharan, Eswara Rao Puppala, Srikanth Ponneganti, Anupam Sarma, V. G. M. Naidu, T. R. Santhoshkumar, Vibin Ramakrishnan
Summary: The research demonstrates that designed and optimized peptides have different uptake abilities in various cancer cells and can penetrate tumorospheres. The cytotoxic effects of these peptides were confirmed to be apoptotic by observing mitochondrial membrane potential depolarization and Caspase-3 activation. Additionally, in vivo and clinical samples studies further confirmed the peptides' ability to selectively recognize tumor cells.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Haidi Feng, Lu Zhao, Zhiqiang Bai, Zhihui Xin, Chaoyu Wang, Lizhen Liu, Jinping Song, Haifei Zhang, Yunfeng Bai, Feng Feng
Summary: In this study, an aptamer modified nanoplatform was designed for active-targeted chemo-photodynamic therapy of tumors. The nanoplatform showed enhanced therapeutic effect and active targeting efficiency under 808 nm laser irradiation.
Article
Chemistry, Multidisciplinary
Lan Yang, Huijie Ma, Ye Liu, Rumeng Cao, Shaofeng Chen, Jiajia Wang, Ling Xiang, Jiumeng Zhang, Xuli Feng, Chenhui Wang
Summary: A nucleus-targeted enzyme prodrug nanocomposite, assembled from β-cyclodextrin-lysine (CL), catalase (CAT), Pt(iv) and chlorin e6 (Ce6), was developed for self-augmenting cascade photo-chemo therapy of tumors. It can effectively transport through the cytoplasm and accumulate in the nucleus, thereby significantly inhibiting tumor growth and lung metastasis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Hai Yang, Zongze Duan, Fengbo Liu, Zhiyong Zhao, Simin Liu
Summary: We developed a universal strategy to fabricate supramolecular DNA nanogels for the codelivery of chemo and photodynamic therapy drugs. The nanogels showed size tunability, host-guest competition, and DNA enzyme responsibility. Cell uptake and MTT experiments demonstrated biocompatibility, specificity, and successful drug release. The combined chemo/photodynamic therapy using the nanogels showed enhanced apoptosis of cancer cells compared to single therapies.
Article
Chemistry, Multidisciplinary
N. Liu, W. Zuo, L. Wu, L. Chen, Z. Xiao, Q. Jin, J. Liu, L. Tu, S. Huo, X. Zhu
Summary: The novel nanotheranostic FePCP-5 was developed to enhance MPO targeting and improve cancer therapy. FePCP-5 can induce cytotoxicity, aggravate inflammation, and increase MPO concentrations through photoirradiation. It can also oxidize D5-HT and aggregate nanotheranostic with the help of increased MPO and intrinsic H2O2. Cisplatin is able to elevate H2O2 and further enhance the targeting efficiency. In vivo experiments confirmed that FePCP-5 significantly enhances intratumoral nanotheranostic accumulation and achieves pronounced tumor inhibition.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Shiming He, Yue Du, Hongyu Tao, Huaiyu Duan
Summary: This review paper summarizes recent advances in aptamer-mediated drug delivery systems in cancer therapy, including aptamer-drug conjugates, aptamer-siRNA, and aptamer-functionalized nanoparticle systems. The article discusses the application prospects and existing challenges of these innovative approaches, highlighting their potential to reduce toxicity and improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Ruihong Lv, Haohao Wang, Yongsheng Ji, Shanshan Gao, Ning Hao, Shanshan Zhang, Yanna Lv, Qilin Zhang, Xiyu Han, Yanting Liu, Zhigang Xu
Summary: This study developed pH and photothermal responsive doxorubicin/curcumin-loaded degradable dendritic mesoporous silica nanoparticles (DNCPDH), in which curcumin acted as an antitumor sensitizer by increasing intracellular ROS level. The DNCPDH nanocarriers exhibited enhanced chemo-photothermal synergistic tumor treatment, efficient intracellular uptake, and high cellular accumulation.
Article
Medicine, Research & Experimental
Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu, Wenting Li, Wei Hong
Summary: Nanoscale structures have been developed for various functions in cancer therapy, including diagnosis, biomedical visualization, tissue regeneration, and drug delivery. By using biocompatible chitosan oligosaccharides and gold nanorods, a drug delivery system was designed that effectively delivered drugs to tumor sites and selectively targeted cancer cells. The system also had drug release capability and magnetic resonance imaging functionality, showing promising outcomes for tumor diagnosis and treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Yanmin Ju, Zhiyi Wang, Zeeshan Ali, Hongchen Zhang, Yazhou Wang, Nuo Xu, Hui Yin, Fugeng Sheng, Yanglong Hou
Summary: This study developed a biomimetic drug delivery nanosystem with tumor targeting, pH-stimuli drug release, and chemo-photothermal therapeutic effects. The nanosystem showed enhanced immune escape and cellular uptake of cancer cells, stable drug release at acidic pH, and photothermal destruction of tumor tissue, leading to improved chemotherapeutic efficacy.
Article
Chemistry, Medicinal
Chunlei Wu, Zhehong Cheng, Danyi Lu, Ke Liu, Yulian Cheng, Pengxin Wang, Yimin Zhou, Meiqing Li, Ximing Shao, Hongchang Li, Wu Su, Lijing Fang
Summary: Researchers discovered a simplified analogue of Coibamide A and designed two novel peptide-drug conjugates, with one showing better drug release in vitro and significant tumor growth suppression in mice-bearing human tumor xenografts, indicating great potential in cancer drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Thu Thi Anh Do, Santiago Grijalvo, Toyoko Imae, Maria Jose Garcia-Celma, Carlos Rodriguez-Abreu
Summary: The multifunctional rod-like CNCs-based carriers developed in this study have excellent drug-loading capacity and can be used for targeted drug delivery to tumor cells. They also exhibit fluorescence imaging and photodynamic/photothermal treatment capabilities, with pH-sensitive drug release behavior against cervical cancer cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Medicinal
Xinyue Hu, Hailun Jiang, Weiqi Bai, Xiujun Liu, Qingfang Miao, Linlin Wang, Jie Jin, Along Cui, Rui Liu, Zhuorong Li
Summary: ADCs, composed of a monoclonal antibody and warhead, are a successful strategy for treating solid tumors. Novel linker-MMAE conjugates showed increased activity for some ADCs and potential for treating other types of cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
E. Ragozin, A. Hesin, A. Bazylevich, H. Tuchinsky, A. Bovina, T. Shekhter Zahavi, M. Oron-Herman, G. Kostenich, M. A. Firer, T. Rubinek, I. Wolf, G. Luboshits, M. Y. Sherman, G. Gellerman
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Ankana Roy, Partha Jyoti Das, Yael Diskin-Posner, Michael Firer, Flavio Grynszpan, Michael Montag
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Oncology
S. Yado, G. Luboshits, O. Hazan, R. Or, M. A. Firer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Review
Chemistry, Multidisciplinary
Michael A. Firer, Galia Luboshits
Summary: The development and clinical efficacy of ADCs have attracted significant interest in academia and industry, with ten ADCs having received FDA approval. These drugs specifically deliver cytotoxic agents to target cells, showing promise in providing long-term clinical benefits for patients with hematological malignancies.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ekaterina Guzev, Galia Luboshits, Svetlana Bunimovich-Mendrazitsky, Michael A. Firer
Summary: This study established a mathematical model to predict in vivo drug efficacy from in vitro cytotoxicity studies on murine A20 leukemic cells, showing a good symmetry between experimental results and numerical simulations. The model can be a general tool to study the cytotoxic activity of various drugs with different doses and modes of action through appropriate adjustment of parameters.
Review
Oncology
Michael A. Firer, Michael Y. Shapira, Galia Luboshits
Summary: This review summarizes the effects of commonly used drugs in the induction phase of multiple myeloma therapy on the immune system, aiming to devise more effective treatment regimens. Efforts are being made to understand the impacts of each stage of treatment protocols on overall survival statistics, with a focus on immune reconstitution and anti-tumor immune responses post-autologous stem cell transplantation. By analyzing the immune effects of individual drugs, it may be possible to identify subgroups of patients for whom particular drug combinations would be more appropriate.
Review
Biochemistry & Molecular Biology
Kalishwaralal Kalimuthu, Chenicheri K. Keerthana, Manikandan Mohan, Jaison Arivalagan, Johnson Retnaraj Samuel Selvan Christyraj, Michael A. Firer, Mohammad Haroon Asif Choudry, Ruby John Anto, Yong J. Lee
Summary: This review critically analyzes the molecular mechanisms of selenium metabolism and its potential as a therapeutic target for cancer, highlighting SECISBP2 as a novel prognostic predictor and an alternative target for cancer. Strategies to develop a novel selenium metabolism-based approach for cancer therapy are emphasized, with expectations for extensive clinical use of SECISBP2 as a specific biomarker in cancer therapy. Scientists face additional challenges, including research on anticancer peptides targeting the intracellular protein SECISBP2.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Oncology
Khalid El Bairi, Harry R. Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F. Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L. Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R. Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A. Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L. Rimm, John M. S. Bartlett, Giuseppe Viale, Carsten Denkert, Akira I. Hida, Christos Sotiriou, Sibylle Loibl, Stephen M. Hewitt, Sunil Badve, William Fraser Symmans, Rim S. Kim, Giancarlo Pruneri, Shom Goel, Prudence A. Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi
Summary: The use of immune-checkpoint inhibitors has significantly improved survival in cancer patients, including a subgroup of women with breast cancer who may benefit from this treatment. Studies have shown that tumor-infiltrating lymphocytes are associated with response to both cytotoxic treatments and immunotherapy, particularly in patients with triple-negative breast cancer.
Article
Pathology
Sirish Karri, Sarit Aviel-Ronen, Michael A. Firer
Summary: Colorectal cancer can be divided into two types based on the formation of tertiary lymphoid structures: CRC with a Crohn's like lymphoid reaction and CRC lacking TLSs. Digital image analysis can further divide CRC into at least 3 subgroups, which can help in selecting targeted therapy.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Multidisciplinary Sciences
Ekaterina Guzev, Svetlana Bunimovich-Mendrazitsky, Michael A. Firer
Summary: This study presents a framework for improving cancer chemotherapy through collaboration between mathematicians and experimentalists. Using a model and experimental data, the study compares the cytotoxicity of two FDA-approved anticancer drugs in an in vitro model of Chronic Lymphocytic Leukemia. The results show that the model accurately predicts the effects of the drugs on leukemic cells, and the synergy between the drugs enhances the cytotoxic effect. The study suggests that the model could be used to personalize drug doses based on individual cancer cells' growth rates.
Article
Cell Biology
Ekaterina Guzev, Suchita Suryakant Jadhav, Eleonora Ela Hezkiy, Michael Y. Sherman, Michael A. Firer, Svetlana Bunimovich-Mendrazitsky
Summary: Mathematical models have become an important tool in cancer research, combining quantitative analysis and natural processes. This study focuses on Chronic Lymphocytic Leukemia (CLL) and uses a mathematical model to predict drug efficacy, which could potentially lead to personalized chemotherapy prediction software.
Article
Pharmacology & Pharmacy
Olga Furman, Alisa Zaporozhets, Dror Tobi, Andrii Bazylevich, Michael A. Firer, Leonid Patsenker, Gary Gellerman, Bat Chen R. Lubin
Summary: In this study, a new EGFR-specific cyclic peptide was discovered using phage display peptide technology and biopanning. The peptide showed specific and selective binding and internalization into EGFR-positive cells, and demonstrated high specificity for non-small cell lung cancer and glioblastoma cells. When conjugated to camptothecin, the peptide showed increased cytotoxicity to EGFR-positive cells.
Article
Cell Biology
Eleonora Ela Hezkiy, Santosh Kumar, Valid Gahramanov, Julia Yaglom, Arkadi Hesin, Suchita Suryakant Jadhav, Ekaterina Guzev, Shivani Patel, Elena Avinery, Michael A. Firer, Michael Y. Sherman
Summary: Finding synergistic drug combinations is crucial in cancer research. In this study, researchers identified that inhibitors of proteasome and mTORC1 could synergize with ibrutinib, an FDA-approved inhibitor, for the treatment of chronic lymphocytic leukemia (CLL), through shRNA screening and bioinformatics analysis.
Letter
Immunology
Suchita Suryakant Jadhav, Galia Luboshits, Bjarne Bogen, Michael A. Firer
Summary: This study establishes a murine model to investigate the progression from premalignant to malignant multiple myeloma, observing the development of T-cell exhaustion and suppression prior to the onset of clinical symptoms.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Organic
Partha Jyoti Das, Ankana Roy, Ashim Nandi, Ishita Neogi, Yael Diskin-Posner, Vered Marks, Iddo Pinkas, Sara Amer, Sebastian Kozuch, Michael Firer, Michael Montag, Flavio Grynszpan
Summary: In this study, a series of thioxobimanes were synthesized and extensively characterized. The potential of these compounds as ligands for transition metals was demonstrated.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
