期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 24, 期 18, 页码 4241-4245出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.07.017
关键词
Foldamer; Antibacterial; Membrane; Diarylureas; Conformation
资金
- University of Central Lancashire
By varying the molecular charge, shape and amphiphilicity of a series of conformationally distinct diary-lureas it is possible to control the levels of phospholipid membrane lysis using membranes composed of bacterial lipid extracts. From the data obtained, it appears as though the lysis activity observed is not due to charge, conformation or amphiphilicity in isolation, but that surface aggregation, H-bonding and other factors may also play a part. The work provides evidence that this class of foldamer possesses potential for optimisation into new antibacterial agents. (C) 2016 Elsevier Ltd. All rights reserved.
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