Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

标题
Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
作者
关键词
γ-Glutamyl transpeptidase, Phosphonate diesters, GGsTop, Mechanism-based inhibitor, Electrostatic interaction, Active-site residue Lys562, Selectivity, Cytotoxicity
出版物
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 24, Issue 21, Pages 5340-5352
出版商
Elsevier BV
发表日期
2016-09-09
DOI
10.1016/j.bmc.2016.08.050

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